Author : George Watson
ISBN : 0521200040
Genre : Language Arts & Disciplines
File Size : 37.83 MB
Format : PDF, ePub
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More than fifty specialists have contributed to this new edition of volume 1 of The Cambridge Bibliography of English Literature. The design of the original work has established itself so firmly as a workable solution to the immense problems of analysis, articulation and coordination that it has been retained in all its essentials for the new edition. The task of the new contributors has been to revise and integrate the lists of 1940 and 1957, to add materials of the following decade, to correct and refine the bibliographical details already available, and to re-shape the whole according to a new series of conventions devised to give greater clarity and consistency to the entries.
Constance Spry has been called ¿the first superstar florist¿: her heyday in England lasted from the late 1920s through the `50¿s, during which she arranged flowers for Elsie de Wolfe, for Wallis Simpson¿s wedding to the Duke of Windsor, & for Elizabeth II¿s coronation. Unorthodox arrangements in alternative containers were her trademark. She mixed blooms -- a fairly daring practice in her day -- in order to achieve ¿the thrill of the beholder¿ that the great Dutch & Flemish painters achieved with their still-lifes. She felt ¿strongly that the art of flower arrangement should be a means of self-expression for everyone & that nobody should be afraid to express their feeling for color & line through this medium.¿ This, her first book, has long been out of print.
Appropriate selection of biochemical targets is one of the most important drivers of cost effectiveness in the discovery of new medicines. Despite the many advances in genetics, genomics and systems biology, ‘validation’ of a target is not achieved until therapeutic efficacy is demonstrated by a drug candidate. Volume 46 of this series reviews the medicinal chemistry aimed at six diverse targets from which important new medicines are emerging: * HIV integrase (discovery of the first-in-class inhibitor drug raltegravir) * 11-beta-Hydroxysteroid dehydrogenase (new approach to glucocorticoid regulation) * Nicotinic a7 choline receptor (agonists and positive allosteric modulators). * Bradykinin receptor (new approach to pain therapy) * Histone deacetylase (new drugs for cancer) * 5-HT2c receptor modulators (various CNS indications) *Presents the latest research in the field of drug discovery *Publishes on an annual basis to bring you the most innovative updates in medicinal chemistry *Available as an online resource via ScienceDirect
Includes, beginning Sept. 15, 1954 (and on the 15th of each month, Sept.-May) a special section: School library journal, ISSN 0000-0035, (called Junior libraries, 1954-May 1961). Also issued separately.