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The Paris System For Reporting Urinary Cytology

Author : Dorothy L. Rosenthal
ISBN : 9783319228648
Genre : Medical
File Size : 47.54 MB
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This book describes a novel and proven approach to cytologically classify urinary samples for the detection of bladder cancer and lesions of the upper urinary tract. The new method is based on the collective experience of knowledgeable cytopathologists who have tested the terminology within their own laboratories for reproducibility and predictability of neoplasms of the urinary tract. Accompanying the written criteria for each diagnostic category are meticulously photographed exemplars of the cellular features, with cogently annotated descriptions of the photographs. The book thereby performs as an atlas for microscopists involved in diagnostic cytopathology at all levels of their education. Included in the targeted readership are experienced pathologists, cytotechnologists, and students of both professional groups. The new terminology also considers the clinical aspects of patient management. Written by experts in the field who convened at the 18th International Congress of Cytology in Paris, The Paris System for Reporting Urinary Cytology presents a global standard for reporting and a new philosophic approach that maximizes the strengths of detecting the potentially lethal high grade lesions by urinary cytology, and recognizes without apology the inability to reliably detect the low grade lesions in urinary cytology. The Concept has been endorsed by the American Society Of Cytopathology, and the International Academy of Cytology.
Category: Medical

Implementing The Paris System For Reporting Urinary Cytology Results In A Decrease In The Rate Of The Atypical Category And An Increase In Its Prediction Of Subsequent High Grade Urothelial Carcinoma

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ISBN : OCLC:1051895636
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File Size : 26.95 MB
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Abstract : BACKGROUND: In the current study, the authors evaluated the impact of implementing The Paris System for Reporting Urinary Cytology (PSRUC) on the prevalence of various cytological categories and their association with a subsequent diagnosis of high‐grade urothelial carcinoma (HGUC). METHODS: A comparative study was conducted over the 6‐month period before PSRUC implementation (2013), including 1653 patients and 2371 specimens versus a 6‐month period after implementation of the PSRUC (2016), including 1478 patients and 2392 specimens. The following cytological categories were correlated with the subsequent biopsy result when available (355 cases): negative for HGUC (NHGUC), atypical urothelial cells (AUC), suspicious for HGUC, and HGUC. RESULTS: Although 18.6% of specimens were diagnosed as AUC in 2013, the percentage was 14.4% in 2016 ( P

Management Of Urothelial Carcinoma

Author : Ja Hyeon Ku
ISBN : 9789811055027
Genre : Medical
File Size : 69.23 MB
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This book provides a comprehensive overview of contemporary evidence-based management of urothelial carcinoma. The first part of the book is devoted to urothelial carcinoma of the bladder and includes detailed description of the diagnosis and treatment of non-muscle-invasive, muscle-invasive, and advanced or metastatic disease. Attention then turns to upper tract urothelial carcinoma (UTUC), with individual chapters on diagnosis, nephron-sparing surgery, nephroureterectomy, and treatment of advanced or metastatic UTUC. The text is supported by many illustrations, photos, and tables that clarify management, and surgical video clips are also available to readers. The book will be a welcome addition to the literature as progress continues to be made in understanding the exact pathophysiology of urothelial carcinoma and in developing more effective diagnostic and therapeutic modalities. It will be useful both to researchers in the field of urothelial carcinoma and to clinicians, including especially residents and fellows.
Category: Medical

Cytopathology An Issue Of Surgical Pathology Clinics

Author : Vickie Jo
ISBN : 9780323614153
Genre : Medical
File Size : 50.47 MB
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This issue of Surgical Pathology Clinics, edited by Dr. Vickie Jo, focused on Cytopathology. Topics include--but are not limited to--Head and Neck Cytology: HPV-Associated Carcinomas; Updates in Thyroid Cytology; Salivary Gland Cytopathology; Pulmonary Cytopathology; Updates in Effusion Cytology; Updates in Gynecologic Cytology; Diagnostic Advances in Urine Cytology; Renal Neoplasms; Pancreaticobiliary Cytology; Carcinoma of Unknown Primary; Soft Tissue Neoplasms; Primary Bone Tumors; Pediatric Cytopathology; Advances in Molecular Testing Techniques in Cytological Specimens; and Circulating Tumor Cells: Applications in Cytopathology.
Category: Medical

Molecular Applications In Cytology

Author : Fernando C. Schmitt
ISBN : 9783319749426
Genre : Medical
File Size : 45.45 MB
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This book is intended for practicing pathologists and cytopathologists, as well as for pathology trainees and cytotechnicians. It starts with a detailed description of the extremely important pre-analytical phase for molecular testing followed by a presentation of the key tests and their application in different organs, e.g. the lung or thyroid. Step-by-step instructions for the different assays, reporting and clinical integration of the test results are discussed. The authors help the reader to benefit from their experiences by providing a valuable tool for the implementation of these techniques in daily practice. Though the use of molecular techniques is well established in surgical biopsies, to date they are not widely used in connection with cytological material. However, in some fields like lung cancer or aspirates from the pancreas and biliary tract the only available material for diagnosis is the cytological preparation a fact that has created a need for the standardization of molecular techniques on cytology.
Category: Medical

Case Based Approach In Exfoliative Cytology

Author : Pranab Dey
ISBN : 9789386261892
Genre : Medical
File Size : 66.35 MB
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Exfoliative cytology, which is a quick and simple procedure, is an important alternative to biopsy in certain situations. In exfoliative cytology, cells shed from body surfaces, such as the inside of the mouth, are collected and examined. This technique is useful only for the examination of surface cells and often requires additional cytological analysis to confirm the results (Encyclopaedia Britannica). This book is a comprehensive guide to exfoliative cytopathology presenting 215 real cases supplemented with clinical details and microphotographs. Each case covers a description of the problem, diagnostic criteria and features, differential diagnosis and immunocytochemistry, and treatment options. Divided into eight sections, the book presents cases highlighting cytology in different systems of the body – general, cervical, effusion, respiratory, gastrointestinal tract, urine, cerebrospinal fluid, concluding with a chapter on miscellaneous topics. Cases are presented in multiple choice question format, with detailed answers and suggestions for further reading. Key Points Comprehensive guide to exfoliative cytology Presents 215 real cases supplemented with clinical details and microphotographs Covers cytology of different systems of the body Cases presented in multiple choice question format
Category: Medical

Urologic Surgical Pathology E Book

Author : Liang Cheng
ISBN : 9780323550628
Genre : Medical
File Size : 42.64 MB
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Offering comprehensive coverage of this fast-changing field for more than 20 years, Urologic Surgical Pathology is an expert guide to all common and rare entities in the genitourinary system. The 4th Edition keeps you fully up to date with discussions of newly recognized tumors and terminologies, the latest classification schemes, current grading approaches, molecular alterations, and commonly used ancillary diagnostic techniques. With its clinical focus on day-to-day urological pathology sign-out and an emphasis on clinicopathologic and radiographic-pathologic correlations, this thoroughly revised uropathology reference is an excellent resource for diagnostic decision making. Includes expanded coverage of differential diagnosis for all tumor types encountered in urological surgical pathology practice. Incorporates the latest TNM staging and WHO classification systems, as well as new diagnostic biomarkers and their utility in differential diagnosis, newly described variants and new histologic entities. Discusses advances in molecular diagnostic testing, its capabilities, and its limitations, including targeted therapy/personalized medicine. Covers new developments in immunohistochemistry and the latest diagnostic tumor markers. Features more than 1,600 high-quality images – all in color – including gross pictures, histopathologic and cytopathologic images, special stains, other ancillaries, drawings, and illustrations. Helps you find information quickly with a consistent chapter format; an abundance of tables, diagrams and flowcharts; boxed lists of types and causes of diseases; differential diagnosis; characteristic features of diseases; complications; classifications; and staging.
Category: Medical

The Risk Of Malignancy Of Atypical Urothelial Cells Of Undetermined Significance In Patients Treated With Chemohyperthermia Or Electromotive Drug Administration

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ISBN : OCLC:1051803462
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File Size : 58.78 MB
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Abstract : BACKGROUND: Chemohyperthermia (C‐HT) or electromotive drug administration (EMDA) are alternative therapies to radical cystectomy in patients with non‐muscle‐invasive bladder cancer who do not respond to intravesical therapy with bacille Calmette‐Guérin. METHODS: The authors investigated a group of 87 patients with a diagnosis of high‐grade non‐muscle‐invasive bladder carcinoma or carcinoma in situ. Of these, 45 patients received EMDA of mitomycin (EMDA/MMC) and 42 patients were treated with C‐HT and mitomycin therapy (C‐HT/MMC). In accordance with the Paris System for Reporting Urinary Cytology, a cytological diagnosis was made and patients with diagnoses of atypical urothelial cells (AUC), suspicious high‐grade urothelial carcinoma (SHGUC), or high‐grade urothelial carcinoma also underwent histological bladder biopsies. RESULTS: In accordance with the Paris System for Reporting Urinary Cytology, the AUC cases may have cytological features of SHGUC present on atypical degenerated cells. In analyzing the AUC group without the SHGUC cases diagnosed on the basis of degenerated urothelial cells, the authors found a significant association between the AUC category and a negative histological biopsy. The SHGUC group, including cases with a SHGUC diagnosis rendered on degenerated urothelial cells, was associated with high‐grade urothelial carcinoma or carcinoma in situ ( P = .0269 for patients treated with EMDA/MMC and P = .0049 for patients treated with C‐HT/MMC). CONCLUSIONS: In the urine samples from patients treated with EMDA/MMC or C‐HT/MMC, a diagnosis of SHGUC could be made even on degenerated urothelial cells when considering cellular degeneration as a "physiological" consequence of the treatment that involves either normal or neoplastic cells. Cancer Cytopathol 2018;126:200‐6. © 2018 American Cancer Society. Abstract : Chemohyperthermia or electromotive drug administration are alternative therapies to radical cystectomy in patients with non‐muscle‐invasive bladder cancer. In urine samples from patients treated with electromotive drug administration or chemohyperthermia, a diagnosis of suspicious high‐grade urothelial carcinoma may be rendered even on degenerated urothelial cells when considering the cellular degeneration as a "physiological" consequence of the treatment that involves either normal or neoplastic cells.

When Words Matter A Suspicious Urinary Tract Cytology Diagnosis Improves Patient Follow Up Among Nonurologists

Author :
ISBN : OCLC:1052011805
Genre :
File Size : 22.9 MB
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Abstract : BACKGROUND: Urinary tract cytology (UTC) specimens diagnosed using high‐risk indeterminate categories such as "atypical urothelial cells, cannot exclude high‐grade urothelial carcinoma" (AUC‐H) or "suspicious for high‐grade urothelial carcinoma" (SHGUC) have a high rate of detection of high‐grade urothelial carcinoma on subsequent biopsy. Although urologists are familiar with such terminology, it is unclear whether patients receive appropriate follow‐up when UTC is ordered by nonurologists. In the current study, the authors investigated whether the use of AUC‐H versus SHGUC altered patient management among nonurologists. METHODS: Specimens signed out as AUC‐H or SHGUC were identified from the archives of the study institution, which included periods of time before the use of the standardized Johns Hopkins Hospital template, during use of the Johns Hopkins Hospital template, and after institution of The Paris System for Reporting Urinary Cytology. RESULTS: Approximately one‐half of the specimens diagnosed as AUC‐H were not investigated further when ordered by nonurologists. Patients with specimens diagnosed as AUC‐H received fewer subsequent biopsies (14% vs 53%; P