The Mouse In Biomedical Research Volume 4

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The Mouse In Biomedical Research

Author :
ISBN : 008046906X
Genre : Science
File Size : 87.19 MB
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History, Wild Mice, and Genetics, the first volume in the four volume set, The Mouse in Biomedical Research, provides information about the history, biology and genomics of the laboratory mouse (Mus musculus), as well as basic information on maintenance and use of mouse stocks. Mouse origins and relationships are covered in chapters on history, evolutionary taxonomy and wild mice. Genetics and genomics of the mouse are covered in chapters on genetic nomenclature, gene mapping, cytogenetics and the molecular organization of the mouse genome. Maintenance of laboratory mice is described in chapters on breeding systems for various types of strains and stocks and genetic monitoring. Use of the mouse as a model system for basic biomedical research is described in chapters on chemical mutagenesis, gene trapping, pharmacogenetics and embryo manipulation. The information in Volume 1 serves as a primer for scientists new to the field of mouse research.
Category: Science

The Mouse In Biomedical Research

Author : Henry Foster
ISBN : 9780323156066
Genre : Science
File Size : 67.96 MB
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The Mouse in Biomedical Research, Volume I: History, Genetics, and Wild Mice focuses on the utility of the mouse as a laboratory animal in biomedical research. A historical perspective on the development and origins of the laboratory and wild mouse is given. The diversity of inbred strains of mice as well as the methods of developing and the genetic monitoring and testing of these strains are discussed. This volume consists of 14 chapters and begins with an overview of mice of the genus Mus and problems concerning evolution within the genus. The following chapters focus on taxonomy, nomenclature, and breeding systems, together with recombinant inbred and congenic resistant mouse strains. Methods of constructing, testing, and monitoring strains are described. Congenic strains, gene mapping, cytogenetics, and murine experimental studies are also considered, along with the histocompatibility-2 complex and radiation genetics. The final chapter is devoted to the pharmacogenetics of the laboratory mouse, paying particular attention to intoxication and detoxication pathways, genetically determined differences in xenobiotic metabolism, and pharmacogenetic polymorphisms. This book will be a useful reference for investigators using mice in many areas of research.
Category: Science

Gene Knockout Protocols

Author : Martin J. Tymms
ISBN : 9781592592203
Genre : Science
File Size : 58.22 MB
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As the major task of sequencing the human genome nears completion and the full complement of human genes are catalogued, the task of understanding the normal biological functions of genes and how their alteration leads to diseased states becomes more imperative. In Gene Knockout Protocols, highly skilled investigators with extensive experience in gene targeting and mouse genetics describe their best techniques for the design of targeting constructs and for genetic phenotype analysis. These proven methods contain step-by-step instructions, as well as notes on pitfalls to avoid, and emphasize techniques that are relevant to researchers carrying out gene targeting work. These include embryo transplantation, in vitro embryonic stem cell differentiation, creation of aggregation chimeras, mouse pathology, embryo cryopreservation, and transplantation. Issues such as the use of existing mouse mutation resources and the influence of genetic background and epigenetic effects upon phenotype are also covered. State-of-the-art and highly practical, Gene Knockout Protocols not only constitutes an invaluable source of readily reproducible techniques for those just entering the field of gene targeting, but also a key reference for all genetic researchers today.
Category: Science

Male Mediated Developmental Toxicity

Author : Andrew F. Olshan
ISBN : 9781461518778
Genre : Medical
File Size : 66.45 MB
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The cause of many of the adverse reproductive outcomes and developmental diseases among offspring is not well understood. Most of the epidemiologic and experimental animal research has focused on the relationship between maternal exposures including medications, tobacco smoke, alcohol, infections, and occupation and the occurrence of spontaneous abortion, low birth weight, and birth defects. The potential role of paternal exposures has not been investigated as extensively despite long-standing animal research that demonstrates the induction of mutations in the male germ cell after exposure to certain agents and subsequent reproductive failure or early pregnancy loss. Given this relative lack of interest, acquisition of epidemiologic data and the development of a definitive model or mechanism for potential male-mediated effects has been hindered. However, recent laboratory and epidemiologic investigations have suggested that paternal exposures may be more important than previously suspected. This topic has been termed by some as "male-mediated developmental toxicity. " This is meant to refer to the effects of exposures and other factors relating to the male parent that result in toxicity to the conceptus and abnormal development. The developmental endpoints of interest can include fetal loss, congenital abnormalities, growth retardation, cancer, and neurobehavioral effects. These effects may operate through a variety of mechanisms including gene mutation, chromosomal aberrations, seminal fluid transfer of toxicants and epigenetic events.
Category: Medical

Handbook Of Rodent And Rabbit Medicine

Author : Kathy Laber-Laird
ISBN : CHI:46282655
Genre : Nature
File Size : 87.11 MB
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Rodents & rabbits represent a significant percentage of modern day pets & therefore present a challenge to the veterinarian in a small animal practice. Written by internationally renowned experts, this text contains chapters covering rabbits, quines pigs, hamsters, chincillas, mice, rats & gerbils. Each specific animal chapter covers nutrition, infectous diseases, anaesthesia, metabolic diseases & parasitic infections. The combined experience outlined in this handbook is comprehensive & will provide the veterinarian with the best available guidance in this area of medicine.
Category: Nature

Tumours Of The Mouse

Author : International Agency for Research on Cancer
ISBN : 9283221117
Genre : Medical
File Size : 52.11 MB
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This book provides a comprehensive, coherent source of reference information for experimental pathologists involved in chronic toxicology research. It is a new edition of the second volume in the series, and contains comprehensive classification and description of tumours in the mouse. Each chapter deals with tumours of a particular organ or system, and covers all neoplasms that have been reported to occur, using the proposed WHO terminology for human tumours wherever possible.
Category: Medical

Laboratory Animal Science

Author :
ISBN : UCSC:32106015368746
Genre : Laboratory animals
File Size : 81.61 MB
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Category: Laboratory animals

Federation Proceedings

Author : Federation of American Societies for Experimental Biology
ISBN : UOM:39015010073198
Genre : Biology
File Size : 58.33 MB
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Vols. for 1942- include proceedings of the American Physiological Society.
Category: Biology


Author : Henry L. Foster
ISBN : 9781483269139
Genre : Medical
File Size : 49.52 MB
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The Mouse in Biomedical Research, Volume II: Diseases is a compilation of papers detailing infectious diseases of the mouse. This compilation deals with bacterial, mycotic, viral, protozoal, rickettsial, parasitic, non-neoplastic, and metabolic diseases of the mouse. Several papers describe the different diseases found in the digestive, respiratory, urogenital, integumentary, central nervous, lymphoreticular, musculoskeletal, cardiovascular, and endocrine systems of the mouse. This book lists the possible bacterial infections, as well as other miscellaneous infections such as those caused by aerosols, particles, and the air in the laboratory environment. This text also lists viruses that can affect the mouse such as the lactate dehydrogenase-elevating virus, mouse pox, polyomavirus, and the minute virus. This book describes the process of identification, diagnosis, epidemiology, treatment, control, prevention, and occurrence of these diseases. This text also reviews the diseases that can be transmitted from infected mice to humans, as well as through animal bites and allergic reactions. This book is suitable for researchers, clinical assistants, and scientists dealing with laboratory animals, particularly with mice as test animals. This book can also be helpful for veterinarians and doctors of infectious diseases transferred from animals.
Category: Medical

What Animals Want

Author : Larry Carbone
ISBN : 9780199882991
Genre : Medical
File Size : 20.52 MB
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Larry Carbone, a veterinarian who is in charge of the lab animal welfare assurance program at a major research university, presents this scholarly history of animal rights. Biomedical researchers, and the less fanatical among the animal rights activists will find this book reasonable, humane, and novel in its perspective. It brings a novel, sociological perspective to an area that has been addressed largely from a philosophical perspective, or from the entrenched positions of highly committed advocates of a particular position in the debate.
Category: Medical

Ferrets Rabbits And Rodents E Book

Author : Katherine Quesenberry
ISBN : 9781437702880
Genre : Medical
File Size : 22.6 MB
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A concise guide to the care of small mammals, Ferrets, Rabbits, and Rodents: Clinical Medicine and Surgery covers the conditions seen most often in veterinary practice. The book emphasizes preventive medicine along with topics including disease management, ophthalmology, dentistry, and zoonosis. More than 400 illustrations demonstrate key concepts related to radiographic interpretation, relevant anatomy, and diagnostic, surgical, and therapeutic techniques. Now in full color, this edition adds coverage of more surgical procedures and expands coverage of zoonotic disease. From editors Katherine Quesenberry and James W. Carpenter, along with a team of expert contributors, the "Pink Book" provides an authoritative, single source of information that is hard to find elsewhere. A logical organization makes it quick and easy to find important information, with each section devoted to a single animal and chapters within each section organized by body system. Over 400 photographs and illustrations highlight key concepts such as radiographic interpretation and the main points of diagnostic, surgical, and therapeutic techniques. A chapter on ophthalmology provides hard-to-find information on eye care for ferrets, rabbits, rodents, and other small mammals. Coverage of preventive medicine includes basic biology, husbandry, and routine care of the healthy animal. The drug formulary supplies dosage instructions for ferrets, rabbits, guinea pigs, chinchillas, hamsters, rats/mice, prairie dogs, hedgehogs, and sugar gliders. Chapter outlines offer at-a-glance overviews of the contents of each chapter. Handy tables and charts make it easy to find key information. Expanded Zoonotic Diseases chapter adds more depth along with the latest information on the rising potential for disease transmission to humans as exotic pets become more popular. Additional surgical procedures for each species are included, some with step-by-step instructions accompanied by color photographs and line drawings. Full-color images show the sometimes minute structures of these small animals and make accurate diagnoses easier, especially for lymphoproliferative diseases of rabbits, endoscopy, cytology, and hematology.
Category: Medical

The Clinical Chemistry Of Laboratory Animals

Author : Walter F. Loeb
ISBN : UOM:39015016969266
Genre : Animaux de laboratoire - Composition - Tables
File Size : 51.66 MB
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Millions of individual clinical chemistry determinations are performed annual on specimens from rats, mice, and other lab species in the course of biomedi studies. Information obtained is used in a plethora of journal publications agency reports. The objective here is to make this data readily avail.
Category: Animaux de laboratoire - Composition - Tables

Issues And Reviews In Teratology

Author : H. Kalter
ISBN : 9781461305217
Genre : Medical
File Size : 53.15 MB
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Why Efforts to Expand the Meaning of "Teratogen" Are Unacceptable Disagreement about nomenclature in teratology is not new. Dissent even about the very fabric of the discipline-what congenital malformations consist of-has often been voiced. Time, instead of resolving such diffi culties, has sometimes worsened them. For example, in the past it was agreed that congenital malforma tions are abnormalities of structure present at birth, but differences of opinion concerning where the line between normal and abnormal was to be drawn prevailed. It was obvious that, in order to discover the causes of congenital malformations and cast strategies for their prevention, it would be necessary to have knowledge of the baseline of their frequency, and that this required uniformity of definition of terms. Since malfor mations of primary social concern are those having grave outcomes (and are, paradoxically, also the commonest ones), it is logical that such condi tions were the first consideration of investigators and were the defects whose frequency was considered to comprise the required baseline.
Category: Medical

Human Animal Medicine E Book

Author : Peter M. Rabinowitz
ISBN : 9781437711868
Genre : Medical
File Size : 49.10 MB
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Human-Animal Medicine is an innovative reference exploring the unprecedented convergence of human, animal, and environmental health, triggering global pandemics and requiring new clinical paradigms. The "One Health" approach calls for greater communication and cooperation between human health care providers, public health professionals, and veterinarians to better address vital issues of emerging diseases and environmental change. This incredibly timely book provides, for the first time, practical guidelines for "One Health" collaborations in a wide range of clinical human-animal health issues, including the H1N1 virus, zoonotic diseases, the human-animal bond, animal allergy, bites and stings, and animals as "sentinels" for toxic environmental health hazards. UNIQUE! For each condition, specific steps human health care providers, veterinarians, and public health professionals must take to prevent and manage disease. UNIQUE! Comparative tables of disease signs, diagnosis and treatment in humans and animals for easy reference. UNIQUE! Guidelines to detect and improve environmental factors affecting the health of humans and animals. Occupational health guidelines for preventive care of animal workers including veterinary personnel, farmers, pet store employees, and zoo workers. Treatment of emerging disease issues including zoonoses, H1N1 virus, harmful algae blooms, and animal-related pesticides UNIQUE! Sample protocols facilitate professional communication between veterinarians, human health clinicians, and public health professionals. Legal and ethical aspects of "One Health" that human health providers and veterinarians need to know.
Category: Medical

Nonhuman Primates I

Author : Thomas C. Jones
ISBN : 9783642849060
Genre : Medical
File Size : 69.97 MB
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The International Life Sciences Institute (ILSI) was estab lished in 1978 to stimulate and support scientific research and educational programs related to nutrition, toxicology, and food safety, and to encourage cooperation in these programs among scientists in universities, industry, and government agencies to assist in the resolution of health and safety issues. To supplement and enhance these efforts, ILSI has made a major commitment to supporting programs to harmonize toxicologic testing, to advance a more uniform interpreta tion of bioassay results worldwide, to promote a common understanding of lesion classifications, and to encourage wide discussion of these topics among scientists. The Mo nographs on the Pathology of Laboratory Animals are de signed to facilitate communication among those involved in the safety testing of foods, drugs, and chemicals. The complete set will cover all organ systems and is intended for use by pathologists, toxicologists, and others con cerned with evaluating toxicity and carcinogenicity stu dies. The international nature of the project - as reflected in the composition of the editorial board and the diversity of the authors and editors -strengthens our expectations that understanding and cooperation will be improved worldwide through the series. Alex Malaspina President International Life Sciences Institute Preface This book, on Nonhuman Primates, is the eleventh volume of a set pre pared under the sponsorship of the International Life Sciences Institute (ILSI).
Category: Medical