The Hemopoietic Colony Stimulating Factors

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The Hemopoietic Colony Stimulating Factors

Author : Donald Metcalf
ISBN : 0521461588
Genre : Medical
File Size : 41.60 MB
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A detailed account for cell biologists and clinicians of the colony-stimulating factors.
Category: Medical

Colony Stimulating Factors

Author : John M. Garland
ISBN : 9781000148459
Genre : Science
File Size : 75.44 MB
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Concentrating on proven data and adopting a structure-function approach, this text provides grounding for an intricate understanding of the molecular biology, physiological mechanisms, and routine clinical use in disease settings of colony-stimulating factors (CSFs). This edition includes eight additional chapters, with updates of recently-discovered and established CSFs, each indexed individually.
Category: Science

Hematopoietic Growth Factors In Oncology

Author : George Morstyn
ISBN : 9781592597475
Genre : Medical
File Size : 59.74 MB
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Whether to promote platelet recovery or to ameliorate the complications of cancer and the side effects of chemotherapy, hematopoietic growth factors (HGFs) now account for more than $5 billion per year of the US health care budget. In Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Therapeutics, leading oncologists, hematologists, and nephrologists comprehensively review the role of HGFs in clinical practice, explain the molecular basis of their effects, and consider potential future developments. The authors focus on the use of HGFs in oncology, describing their cutting-edge application to patients with lung cancer, Hodgkin's and non-Hodgkin's lymphoma, breast cancer, chronic lymphocytic leukemia, AIDS-related malignancies, myelodysplastic syndromes, and aplastic anemias. Among the HGFs described are granulocyte colony-stimulating factor, erythropoietc factors, thrombopoietic factors, and stem-cell factor and its receptor, c-kit. To complete their survey, the contributors also consider the safety and economic implications of HGFs and the future potential for HGF antagonists in oncology. Comprehensive and up-to-date, Hematopoietic Growth Factors in Oncology: Basic Science and Clinical Practice offers an integrated survey of the role of HGFs in treating and preventing anemia, neutropenia, and thrombocytopenia in patients with malignant and nonmalignant diseases, along with fresh insights into drug development and how basic discoveries in this area can be optimally translated into clinical benefit.
Category: Medical

Handbook Of Growth Factors

Author : Enrique Pimentel
ISBN : 0849325072
Genre : Medical
File Size : 57.61 MB
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Handbook of Growth Factors, Volume III is devoted to hematopoiesis and its regulation by endogenous factors with growth stimulatory and growth inhibitory properties. The book provides detailed discussions on signaling agents related to the regulation of hematopoiesis, including the interleukins, the colony-stimulating factors, the interferons, the tumor necrosis factors, the erythropoietic growth factors, the platelet-derived growth factor, the leukemia inhibitory factor, and the transferrins. The structure and function of each factor is covered in detail, as well as its receptor and postreceptor mechanism of action and its possible role in neoplastic processes. The book also explores the present state of the knowledge about megakaryocyte growth factors and macrophage-derived growth factors.
Category: Medical

Colony Stimulating Factors

Author : F. R. Seiler
ISBN : CORNELL:31924073366118
Genre : Colony-stimulating factors (Physiology)
File Size : 25.84 MB
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Category: Colony-stimulating factors (Physiology)

Cytokines And Cytokine Receptors

Author : Constantin A. Bona
ISBN : 9057026341
Genre : Science
File Size : 41.93 MB
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The field of cytokine research is expanding at a rapid pace Contributions from the major leading groups in the world on the structure and biological properties of cytokine and cytokine receptors, as well as integrated reviews on cytokines in various physiological and pathological conditions were presented in three issues of International Reviews of Immunology This collection of articles provided a unique source of information However, important discoveries are emerging very rapidly and some of the reviews written in 1997 are already outdated In this book, the editors assemble reviews that have been updated by their authors to include all the recent publications and unpublished data from the authors' laboratories This volume should serve as an excellent reference source for all those concerned by the multiple faces of cytokines in basic research and in the clinic
Category: Science

Colony Stimulating Factors Advances In Research And Application 2013 Edition

Author :
ISBN : 9781481698924
Genre : Science
File Size : 84.29 MB
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Colony-Stimulating Factors—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Recombinant Colony-Stimulating Factors. The editors have built Colony-Stimulating Factors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Recombinant Colony-Stimulating Factors in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Colony-Stimulating Factors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Category: Science

Colony Stimulating Factors

Author : T. Michael Dexter
ISBN : UOM:39015016936968
Genre : Colony-stimulating factors (Physiology).
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Balances an overview of the subject with current research results. Introductory chapters cover stem cells and narrow biology and receptors. The various factors useful in genetic cloning are then discussed in detail, for example the relation of factors to leukemias, and the involvement of the lymphoid system. Also discussed are problems faced by commercial concerns in bringing products expensively produced in small laboratory quantities into large-scale, cost- effective, and efficient production; the use of CSF's in clinical practice; and such areas of ongoing research as the process of signal transduction and the control of gene activation. Intended to introduce the specialist in molecular genetics to the cellular results of his work, and the cellular scientist to the molecular aspects. Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com)
Category: Colony-stimulating factors (Physiology).

Hematopoietic Cell Growth Factors Advances In Research And Application 2013 Edition

Author :
ISBN : 9781481676373
Genre : Science
File Size : 50.89 MB
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Hematopoietic Cell Growth Factors—Advances in Research and Application: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Stem Cell Factor. The editors have built Hematopoietic Cell Growth Factors—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Stem Cell Factor in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Hematopoietic Cell Growth Factors—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Category: Science

Humoral Factors In The Regulation Of Tissue Growth

Author : Piero P. Foa
ISBN : 9781461392729
Genre : Medical
File Size : 86.3 MB
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Experts in the field of endocrinology as well as ophthalmologists, oncologists, orthopedists and oral surgeons discuss the nature and mechanism of action of growth-stimulating substances whose biological and clinical activities in humans have been demonstrated or are being investigated. The monograph represents a good sampler of current basic and applied knowledge in the field.
Category: Medical

Colony Stimulating Factors

Author :
ISBN : CORNELL:31924073487849
Genre : Colony-stimulating factors (Physiology)
File Size : 73.20 MB
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Category: Colony-stimulating factors (Physiology)

Advances In Allogeneic Hematopoietic Stem Cell Transplantation

Author : Richard K. Burt
ISBN : 0792377141
Genre : Medical
File Size : 90.38 MB
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The field of hematopoietic stem cell transplantation is rapidly evolving. Realization that hematopoietic stem cells give rise to the immune compartment has resulted in clinical trials of hematopoietic stem cell transplantation for patients with autoimmune diseases. Allogeneic hematopoietic transplants are a form of adoptive immunotherapy resulting in beneficial graft versus tumor effects. Large numbers of hematopoietic cells can be collected with ease. Therefore, a renewable source of cells for ex vivo genetic manipulations is readily available. Multiple trials combining hematopoietic transplants and gene therapy are in progress. One such application is the infusion of allogeneic lymphocytes containing a suicide gene to abort graft versus host disease. Hematopoietic stem cell transplantation is in reality the clinical and practical application of cellular therapy. Hematopoietic transplant physicians are by design or by practical application evolving into cell and gene therapy specialists. The excitement and enthusiasm in hematopoietic transplantation is that it offers a door to the future. A future not of drugs or titrating poisonous chemotherapy but rather of cellular and gene therapy. 1 ALLOGENEIC PERIPHERAL BLOOD STEM CELL TRANSPLANTATION FOR HEMATOLOGIC DISEASES Martin Korbling University o/Texas MD. Anderson Cancer Center, Houston, Texas 77030 INTRODUCTION Circulating hematopoietic stem cells have emerged as an alternative to bone marrow (BM) stem cells for allografting. For many years the reconstitutive potential of circulating stem cells was questioned; peripheral blood stem cells (PBSC) were even characterized a waste product (1).
Category: Medical

Cytokines Of The Lung

Author : J. Kelley
ISBN : 082478703X
Genre : Medical
File Size : 84.32 MB
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Focusing on all the major cytokine families, this reference book provides coverage of cytokine regulatory processes in the lung and other tissues and comprehensive descriptions of cytokine functions specific to the lung.;Discussing the diverse cytokine-binding proteins and the role of cytokines in tissue injury and repair processes and extracellular matrix regulations, the book supplies information on amino acid structure and gene regulatory sequences, examines the receptor biology of individual cytokines, illustrates cytokine interactions with their cognate receptors and surveys the phenotypic effects of individual cytokines on target cells. With over 2700 literature citations and figures, this book is a resource for pulmonologists, physiologists, immunologists, cell and molecular biologists, environmental toxicologists, oncologists, and graduate-level and medical school students in these disciplines.
Category: Medical

Cytokines In Hemopoiesis Oncology And Aids

Author : Mathias Freund
ISBN : 9783642755101
Genre : Medical
File Size : 21.34 MB
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The clinical and experimental effects of cytokines have been realized for a long time. The clinical effects of tumor necrosis factor were noted almost 100 years ago. The basic biological effects of interferons and the hemopoietic growth factors have been known for more than 20 years. Given the basis of modern molecular biotechniques, information concern ing the mediators of cellular interactions is expanding almost exponentially. New principles in the regulation of cell growth, microenvironment, immune response, and malignancy are being discoverd right now. New therapeutic options are becoming available and have, in some areas, already crossed the threshold of clinical application. However, the way forward might be more complicated than we are in a position to recognize today. Some of the first optimistic expectations have not yet been fulfilled. Nevertheless, we are experiencing a revolution in medicine. To contribute to this process and to stimulate scientific communi in this field, we have initiated the international symposia on cytokines cation in hemopoiesis, oncology and aids. Major contributions from the first sym posium are published in this book. We thank all the authors for their contri butions, particularly those from the Hannover Medical School, who have worked hard to realize the congress and prepare these proceedings. We also thank the pharmaceutical companies whose support made this book possible. Finally we thank Professors Deicher, Poliwoda, and Riehm, heads of the Departments of Hematology and Oncology, Immunology, and Pediatric Hematology and Oncology, respectively, who encouraged us and gave us their firm support.
Category: Medical

Human Hematopoiesis In Scid Mice

Author : Maria-Grazia Roncarolo
ISBN : 9783662220085
Genre : Science
File Size : 29.7 MB
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This book presents essential information on the use of the immunodeficient C.B.-17 SCID/SCID mouse for studying human hematopoiesis in vivo. Because of the lack of both humoral and cellular immunity, this mouse can be a unique host for implantation of human hematopoietic tissue using different methods. In the first section, in vivo development of human hematopoietic stem cells and differentiation of human T cells are described. In addition, the effects of growth factors and toxic agents of human hematopoiesis are described. The second section contains chapters in which the human immune responses in the SCID mouse are reviewed. The third section covers SCID mouse models to study human infectious diseases, leukemias and genetic disorders.
Category: Science

Supportive Care In Pediatric Oncology

Author : James H. Feusner
ISBN : 9783662443170
Genre : Medical
File Size : 37.8 MB
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This book provides a thorough and up-to-date discussion of key issues in the supportive care of children with cancer. A variety of frequently encountered situations is covered, including infections, metabolic, cardiopulmonary and neurologic emergencies, tumor lysis syndrome, pain, emesis, mucositis, thrombotic disorders, nutritional problems, hyperleukocytosis and acute abdomen. Throughout the emphasis is firmly on evidenced-based guidance developed from the relevant literature. Information is presented in a manner that will enable readers quickly to locate advice when confronted by a supportive care problem in one of their patients. Helpful algorithms are provided and important “take home points” are highlighted in figures and tables. Supportive Care in Pediatric Oncology will be an invaluable source of assistance for a wide range of health professionals involved in pediatric cancer care.
Category: Medical

Cytokines And Colony Stimulating Factors

Author : Dieter Körholz
ISBN : 9781592593453
Genre : Medical
File Size : 88.11 MB
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Hands-on laboratory experts describe for the novice investigator a host of novel technologies and molecular techniques specifically designed to study cellular immunology and promote its gene therapy applications. Presented in step-by-step detail to ensure ready reproducibility, these protocols range from flow cytometric techniques to detect cytokines and growth factors in different specimens, to methods for generating and expanding dendritic cells and hematopoietic progenitors from different origins. Sectional.
Category: Medical

Clinical Applications Of Cytokines And Growth Factors

Author : John R. Wingard
ISBN : 9781461550136
Genre : Medical
File Size : 26.19 MB
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The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off of invading microbes by humoral, cell-mediated, and phagocytic immunity. The activity of the hematopoietic system is staggering: daily, a normal adult produces approximately 2.5 billion erythrocytes, 2.5 billion platelets, and 1 billion granulocytes per kilogram of body weight. This production is adjusted in a timely fashion to changes in actual needs and can vary from nearly none to many times the normal rate depending on needs which vary from day to day, or even minute to minute. In response to a variety of stimuli, the cellular components of the blood are promptly increased or decreased in production to maintain appropriate numbers to optimally protect the host from hypoxia, infection, and hemorrhage. How does this all happen and happen without over or under responding? There has been extraordinary growth in our understanding ofhematopoiesis over the last two decades. Occupying center stage is the pluripotent stern cell and its progeny. Hematopoietic stern cells have been characterized by their capacity for self renewal and their ability to proliferate and differentiate along multiple lineages. Few in number, the stern cell gives rise to all circulating neutrophils, erythrocytes, lymphoid cells, and platelets. In hematopoietic transplantation, the stern cell is capable of restoring long-term hematopoiesis in a lethally irradiated host.
Category: Medical

Allergy And Allergic Diseases

Author : Judah A. Denburg
ISBN : 9781475727760
Genre : Medical
File Size : 90.72 MB
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Allergy and Allergic Diseases has been organized to provide an up-to-date, clinically relevant compilation of one of the most exciting areas of investigation in medicine today-allergic disease, especially as it pertains to the skin, airways, and bowel. With the dramatic rise in the incidence of various allergic disorders worldwide, and the coming of age of the discipline of Clinical Immunology and Allergy, the interface between basic and clinical science in this arena demands highlighting in this comprehensive new syn thesis.1t is with the hope of filling this evident need that Allergy and Allergic Diseases: The New Mechanisms and Therapeutics has been put together. The book's content is divided into both basic and clinical sections, with emphasis on various components of the immune and inflammatory response as they relate to the development of allergic disease. Topics span the range from molecular biology to clinical symptomatology, with an effort to make this of interest to as broad a constituency as possible. This book will therefore be of substantial interest to specialists in Clinical Immunology and Allergy, scientists studying the cellular and molecular biology of in flammation and immunity, as well as internists, teachers, developers of medical school curricula, and members of industry focused on drug discovery and therapeutics. Indeed, a separate section has been added to deal with some specific issues in this latter field.
Category: Medical

Fanaroff And Martin S Neonatal Perinatal Medicine E Book

Author : Richard J. Martin
ISBN : 9780323081115
Genre : Medical
File Size : 41.74 MB
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Fanaroff and Martin’s Neonatal-Perinatal Medicine covers everything you need to improve the quality of life and long-term outcomes of your patients. Drs. Richard J. Martin, Avroy A. Fanaroff, and Michele C. Walsh, along with a multi-disciplinary team of contributors guide you through the sweeping developments in diagnosis and treatment of the mother fetus, and neonate. The completely updated 9th edition keeps you current on the late preterm infant, the fetal origins of adult disease, neonatal anemia, genetic disorders, and more. Get comprehensive guidance on treating patients through a dual focus on neonatology and perinatology. See nuances and details in over 800 illustrations that depict disorders in the clinical setting and explain complex information. Find the information you need easily with indexing in both volumes that provides quick access to specific guidance. Spot genetic problems early and advise parents of concerns thanks to completely new section on this topic. Tackle the health problems associated with preterm births through a new chapter on The Late Preterm Infant. Understand the fetal origins of adult disease through a new chapter that focuses on conditions that originate in the womb. Stay current on the developments and research surrounding neonatal anemia from the entirely new chapter on Blood and Hematopoietic System highlights. Obtain more global perspectives and best practices from an increased number of international contributions in this edition.
Category: Medical