THE CONTINUAL CONDITION

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The Continual Condition

Author : Charles Bukowski
ISBN : 0061942677
Genre : Poetry
File Size : 38.32 MB
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“The Walt Whitman of Los Angeles.” —Joyce Carol Oates “He brought everybody down to earth, even the angels.” —Leonard Cohen, songwriter Arguably the most imitated and influential American poet of the previous half-century, Charles Bukowski remains a counter-culture icon more than a decade after his death. The Continual Condition is a collection of never-before-published poems by the inimitable Bukowski—raw, tough, odes to alcohol, women, work, and despair by a rebel author equally adept at poetry and prose. Charles Bukowski lives on in The Continual Condition, a godsend for admirers of his previous collections Slouching Toward Nirvana, The Pleasures of the Damned, and Love is a Dog From Hell, as well as his novels Factotum, Ham on Rye, and Pulp.
Category: Poetry

Dose Finding By The Continual Reassessment Method

Author : Ying Kuen Cheung
ISBN : 9781420091526
Genre : Mathematics
File Size : 69.86 MB
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As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to "novel" methods proposed in the past two decades. In particular, the Continual Reassessment Method (CRM) and its variations have drawn much attention in the medical community, though it has yet to become a commonplace tool. To overcome the status quo in phase I clinical trials, statisticians must be able to design trials using the CRM in a timely and reproducible manner. A self-contained theoretical framework of the CRM for researchers and graduate students who set out to learn and do research in the CRM and dose-finding methods in general, Dose Finding by the Continual Reassessment Method features: Real clinical trial examples that illustrate the methods and techniques throughout the book Detailed calibration techniques that enable biostatisticians to design a CRM in timely manner Limitations of the CRM are outlined to aid in correct use of method This book supplies practical, efficient dose-finding methods based on cutting edge statistical research. More than just a cookbook, it provides full, unified coverage of the CRM in addition to step-by-step guidelines to automation and parameterization of the methods used on a regular basis. A detailed exposition of the calibration of the CRM for applied statisticians working with dose-finding in phase I trials, the book focuses on the R package ‘dfcrm’ for the CRM and its major variants. The author recognizes clinicians’ skepticism of model-based designs, and addresses their concerns that the time, professional, and computational resources necessary for accurate model-based designs can be major bottlenecks to the widespread use of appropriate dose-finding methods in phase I practice. The theoretically- and empirically-based methods in Dose Finding by the Continual Reassessment Method will lessen the statistician’s burden and encourage the continuing development and implementation of model-based dose-finding methods.
Category: Mathematics

The Continual Improvement Process

Author : Craig Cochran
ISBN : 0971323186
Genre : Benchmarking (Management)
File Size : 80.20 MB
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Continual improvement is not optional. It is a condition of survival. Every organization must have systematic methods for making smart decisions, attacking problems, improving its products and services, and repelling competitors. Anything less than a systematic, disciplined approach is leaving your future in the hands of chance. This book presents a range of practical methods for driving continual improvement throughout the organization. The starting point is leadership, with a clear definition of mission, strategy, and key measures. These themes are then carried throughout the enterprise, informing everyone on the issues that matter most to survival and success. Strategic approaches for the deployment of metrics, review of organizational performance, effective problem solving, internal auditing, process orientation, and cultural development are also described in detail. Practical tools and examples are provided at every step of the way, enabling immediate implementation of the concepts. This book is more than a guide to continual improvement; it is a guide to leading and managing any organization.
Category: Benchmarking (Management)

De Bow S Review

Author : James Dunwoody Brownson De Bow
ISBN : CHI:18359138
Genre : Periodicals
File Size : 31.16 MB
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Category: Periodicals

Guilty Knowledge Guilty Pleasure

Author : William Logan
ISBN : 9780231166867
Genre : Literary Criticism
File Size : 29.90 MB
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William Logan has been a thorn in the side of American poetry for more than three decades. Though he has been called the Òmost hated man in American poetry,Ó his witty and articulate reviews have reminded us how muscular good reviewing can be. These new essays and reviews take poetry at its word, often finding in its hardest cases the greatest reasons for hope. Logan begins with a witty polemic against the wish to have critics announce their aesthetics every time they begin a review. ÒThe Unbearable Rightness of CriticismÓ is a plea to read those critics who got it wrong when they reviewed Lyrical Ballads or Leaves of Grass or The Waste Land. Sometimes, he argues, such critics saw exactly what these books wereÑthey saw the poems plain, yet often did not see that they were poems. In such wrongheaded criticism, readers can recover the ground broken by such groundbreaking books. Logan looks again at the poetry of Wallace Stevens, Frank OÕHara, and Philip Larkin; at the letters of T. S. Eliot, Elizabeth Bishop, and Robert Lowell; and at new books by Louise GlŸck and Seamus Heaney. Always eager to overturn settled judgments, Logan argues that World War II poets were in the end better than the much-lauded poets of World War I. He revisits the secretly revised edition of Robert FrostÕs notebooks, showing that the terrible errors ruining the first edition still exist. The most remarkable essay is ÒElizabeth Bishop at Summer Camp,Ó which prints for the first time her early adolescent verse, along with the intimate letters written to the first girl she loved.
Category: Literary Criticism