Systems Biology And Regulatory Genomics

Download Systems Biology And Regulatory Genomics ebook PDF or Read Online books in PDF, EPUB, and Mobi Format. Click Download or Read Online button to Systems Biology And Regulatory Genomics book pdf for free now.

Systems Biology And Regulatory Genomics

Author : Eleazar Eskin
ISBN : 9783540482932
Genre : Science
File Size : 56.71 MB
Format : PDF
Download : 370
Read : 412

This book constitutes the thoroughly refereed post-proceedings of two joint RECOMB 2005 satellite events: the First Annual Workshop on Systems Biology, RSB 2005 and the Second Annual Workshop on Regulatory Genomics, RRG 2005, held in San Diego, CA, USA in December 2005. It contains 21 revised full papers that address a broad variety of topics in systems biology and regulatory genomics.
Category: Science

Systems Biology

Author : Isidore Rigoutsos
ISBN : 0195345770
Genre : Science
File Size : 27.42 MB
Format : PDF, ePub, Mobi
Download : 781
Read : 921

The advent of genome sequencing and associated technologies has transformed biologists' ability to measure important classes of molecules and their interactions. This expanded cellular view has opened the field to thousands of interactions that previously were outside the researchers' reach. The processing and interpretation of these new vast quantities of interconnected data call for sophisticated mathematical models and computational methods. Systems biology meets this need by combining genomic knowledge with theoretical, experimental and computational approaches from a number of traditional scientific disciplines to create a mechanistic explanation of cellular systems and processes. Systems Biology I: Genomics and Systems Biology II: Networks, Models, and Applications offer a much-needed study of genomic principles and their associated networks and models. Written for a wide audience, each volume presents a timely compendium of essential information that is necessary for a comprehensive study of the subject. The chapters in the two volumes reflect the hierarchical nature of systems biology. Chapter authors-world-recognized experts in their fields-provide authoritative discussions on a wide range of topics along this hierarchy. Volume I explores issues pertaining to genomics that range from prebiotic chemistry to noncoding RNAs. Volume II covers an equally wide spectrum, from mass spectrometry to embryonic stem cells. The two volumes are meant to provide a reliable reference for students and researchers alike.
Category: Science

Gene Regulation And Metabolism

Author : Julio Collado-Vides
ISBN : 0262532689
Genre : Computers
File Size : 37.90 MB
Format : PDF, Mobi
Download : 981
Read : 551

An overview of current computational approaches to metabolism and gene regulation.
Category: Computers

Systems Biology And Synthetic Biology

Author : Pengcheng Fu
ISBN : 0470437979
Genre : Technology & Engineering
File Size : 25.12 MB
Format : PDF, ePub, Docs
Download : 656
Read : 1002

The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches.
Category: Technology & Engineering

Systems Biology And Biotechnology Of Escherichia Coli

Author : Sang Yup Lee
ISBN : 9781402093944
Genre : Science
File Size : 30.50 MB
Format : PDF
Download : 445
Read : 830

Systems biology is changing the way biological systems are studied by allowing us to examine the cell and organism as a whole. Systems biotechnology allows optimal design and development of upstream to downstream bioprocesses by taking a systems-approach. E. coli has been a model organism for almost all biological and biotechnological studies. This book brings together for the first time the state-of-the-art reviews by the world-leading experts on systems biology and biotechnological applications of E. coli. The topics covered include genomics and functional genomics, resources for systems biology, network analysis, genome-scale metabolic reconstruction, modelling and simulation, dynamic modelling and simulation, systems-level analysis of evolution, plasmids and expression systems, protein synthesis, production and export, engineering the central metabolism, synthetic biology, and systems metabolic engineering of E. coli. This book provides readers with guidance on how a complex biological system can be studied using E. coli as a model organism. It also presents how to perform synthetic biology and systems metabolic engineering studies on E. coli with successful examples, the approaches of which can be extended to other organisms. This book will be a complete resource for anyone interested in systems biology and biotechnology.
Category: Science

Genomic Regulatory Systems

Author : Eric H. Davidson
ISBN : 0080525598
Genre : Science
File Size : 39.63 MB
Format : PDF, Docs
Download : 827
Read : 757

The interaction between biology and evolution has been the subject of great interest in recent years. Because evolution is such a highly debated topic, a biologically oriented discussion will appeal not only to scientists and biologists but also to the interested lay person. This topic will always be a subject of controversy and therefore any breaking information regarding it is of great interest. The author is a recognized expert in the field of developmental biology and has been instrumental in elucidating the relationship between biology and evolution. The study of evolution is of interest to many different kinds of people and Genomic Regulatory Systems: In Development and Evolution is written at a level that is very easy to read and understand even for the nonscientist. * Contents Include * Regulatory Hardwiring: A Brief Overview of the Genomic Control Apparatus and Its Causal Role in Development and Evolution * Inside the Cis-Regulatory Module: Control Logic and How the Regulatory Environment Is Transduced into Spatial Patterns of Gene Expression * Regulation of Direct Cell-Type Specification in Early Development * The Secret of the Bilaterians: Abstract Regulatory Design in Building Adult Body Parts * Changes That Make New Forms: Gene Regulatory Systems and the Evolution of Body Plans
Category: Science

Regulatory Genomics

Author : Hon Wai Leong
ISBN : 9781848162518
Genre : Computers
File Size : 75.8 MB
Format : PDF, Kindle
Download : 634
Read : 426

Research in the field of gene regulation is evolving rapidly in the ever-changing scientific environment. Advances in microarray techniques and comparative genomics have enabled more comprehensive studies of regulatory genomics. The study of genomic binding locations of transcription factors has enabled a more comprehensive modeling of regulatory networks. In addition, complete genomic sequences and comparison of numerous related species have demonstrated the conservation of non-coding DNA sequences, which often provide evidence for cis-regulatory binding sites. Systematic methods to decipher the regulatory mechanism are also crucial for corroborating these regulatory networks; key to these methods are motif discovery algorithms that can help predict cis-regulatory elements. These DNA-motif discovery programs are becoming more sophisticated and are beginning to leverage evidence from comparative genomics. These topics and more were discussed at the 3rd Annual RECOMB Workshop on Regulatory Genomics, which brought together more than 90 attendees and included about 22 excellent talks from leading researchers in the field. This proceedings volume contains nine selected, original manuscripts that were presented during the workshop. Book jacket.
Category: Computers

Genomic Control Process

Author : Isabelle Peter
ISBN : 9780124047464
Genre : Science
File Size : 78.67 MB
Format : PDF, ePub
Download : 128
Read : 196

Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. Covers a vast area of current biological research to produce a genome oriented regulatory bioscience of animal life Places gene regulation, embryonic and postembryonic development, and evolution of the body plan in a unified conceptual framework Provides the conceptual keys to interpret a broad developmental and evolutionary landscape with precise experimental illustrations drawn from contemporary literature Includes a range of material, from developmental phenomenology to quantitative and logic models, from phylogenetics to the molecular biology of gene regulation, from animal models of all kinds to evidence of every relevant type Demonstrates the causal power of system-level understanding of genomic control process Conceptually organizes a constellation of complex and diverse biological phenomena Investigates fundamental developmental control system logic in diverse circumstances and expresses these in conceptual models Explores mechanistic evolutionary processes, illuminating the evolutionary consequences of developmental control systems as they are encoded in the genome
Category: Science

Practical Systems Biology

Author : Alistair Hetherington
ISBN : 9781134133031
Genre : Science
File Size : 65.75 MB
Format : PDF
Download : 253
Read : 667

Systems biology is the study of organisms as interacting networks of genes, proteins and reactions. Practical Systems Biology provides a detailed overview of the different approaches used in this relatively new discipline, integrating bioinformatics, genomics, proteomics and metabolomics. Various areas of research are also discussed, including the use of computational models of biological processes, and post-genomic research. Each chapter is written by an experienced researcher and gives an excellent account of various issues of systems biology that is suitable for postgraduate and postdoctoral researchers who are interested in this expanding area of science.
Category: Science

Aspergillus

Author : Masayuki Machida
ISBN : 1904455530
Genre : Science
File Size : 27.75 MB
Format : PDF, Kindle
Download : 317
Read : 510

In-depth reviews of molecular systematics, bioinformatics, systems biology, transcriptional regulation, genetics, genomics, secondary metabolism, ecology, development, and industrial applications.
Category: Science

Evolutionary Genomics And Systems Biology

Author : Gustavo Caetano-Anollés
ISBN : 9781118210710
Genre : Science
File Size : 40.37 MB
Format : PDF, ePub
Download : 944
Read : 988

A comprehensive, authoritative look at an emergent area inpost-genomic science, Evolutionary genomics is an up-and-coming,complex field that attempts to explain the biocomplexity of theliving world. Evolutionary Genomics and Systems Biology isthe first full-length book to blend established and emergingconcepts in bioinformatics, evolution, genomics, and structuralbiology, with the integrative views of network and systems biology. Three key aspects of evolutionary genomics and systems biologyare covered in clear detail: the study of genomic history, i.e.,understanding organismal evolution at the genomic level; the studyof macromolecular complements, which encompasses the evolution ofthe protein and RNA machinery that propels life; and theevolutionary and dynamic study of wiringdiagrams—macromolecular components in interaction—inthe context of genomic complements. The book also features: A solid, comprehensive treatment of phylogenomics, theevolution of genomes, and the evolution of biological networks,within the framework of systems biology A special section on RNA biology—translation, evolutionof structure, and micro RNA and regulation of gene expression Chapters on the mapping of genotypes to phenotypes, the role ofinformation in biology, protein architecture and biologicalfunction, chromosomal rearrangements, and biological networks anddisease Contributions by leading authorities on each topic Evolutionary Genomics and Systems Biology is an idealbook for students and professionals in genomics, bioinformatics,evolution, structural biology, complexity, origins of life,systematic biology, and organismal diversity, as well as thoseindividuals interested in aspects of biological sciences as theyinterface with chemistry, physics, and computer science andengineering.
Category: Science

Systems Biology And Bioinformatics

Author : Kayvan Najarian
ISBN : 9781439882948
Genre : Medical
File Size : 28.85 MB
Format : PDF
Download : 667
Read : 1282

The availability of molecular imaging and measurement systems enables today's biologists to swiftly monitor thousands of genes involved in a host of diseases, a critical factor in specialized drug development. Systems Biology and Bioinformatics: A Computational Approach provides students with a comprehensive collection of the computational methods
Category: Medical

Computational Modeling Of Gene Regulatory Networks

Author : Hamid Bolouri
ISBN : 9781848162204
Genre : Medical
File Size : 37.7 MB
Format : PDF, ePub, Docs
Download : 326
Read : 1212

This book serves as an introduction to the myriad computational approaches to gene regulatory modeling and analysis, and is written specifically with experimental biologists in mind. Mathematical jargon is avoided and explanations are given in intuitive terms. In cases where equations are unavoidable, they are derived from first principles or, at the very least, an intuitive description is provided. Extensive examples and a large number of model descriptions are provided for use in both classroom exercises as well as self-guided exploration and learning. As such, the book is ideal for self-learning and also as the basis of a semester-long course for undergraduate and graduate students in molecular biology, bioengineering, genome sciences, or systems biology.
Category: Medical

Frontiers In Computational And Systems Biology

Author : Jianfeng Feng
ISBN : 1849961964
Genre : Science
File Size : 54.52 MB
Format : PDF, ePub, Mobi
Download : 944
Read : 256

Biological and biomedical studies have entered a new era over the past two decades thanks to the wide use of mathematical models and computational approaches. A booming of computational biology, which sheerly was a theoretician’s fantasy twenty years ago, has become a reality. Obsession with computational biology and theoretical approaches is evidenced in articles hailing the arrival of what are va- ously called quantitative biology, bioinformatics, theoretical biology, and systems biology. New technologies and data resources in genetics, such as the International HapMap project, enable large-scale studies, such as genome-wide association st- ies, which could potentially identify most common genetic variants as well as rare variants of the human DNA that may alter individual’s susceptibility to disease and the response to medical treatment. Meanwhile the multi-electrode recording from behaving animals makes it feasible to control the animal mental activity, which could potentially lead to the development of useful brain–machine interfaces. - bracing the sheer volume of genetic, genomic, and other type of data, an essential approach is, ?rst of all, to avoid drowning the true signal in the data. It has been witnessed that theoretical approach to biology has emerged as a powerful and st- ulating research paradigm in biological studies, which in turn leads to a new - search paradigm in mathematics, physics, and computer science and moves forward with the interplays among experimental studies and outcomes, simulation studies, and theoretical investigations.
Category: Science

From Fundamental Genomics To Systems Biology

Author : European Commission. Directorate General for Research
ISBN : STANFORD:36105210629064
Genre : Business & Economics
File Size : 30.24 MB
Format : PDF
Download : 920
Read : 1249

Accompanying CD-ROM contains text.
Category: Business & Economics

Genomic Signal Processing And Statistics

Author : Edward R. Dougherty
ISBN : 9789775945075
Genre : Science
File Size : 63.47 MB
Format : PDF, ePub
Download : 294
Read : 180

Recent advances in genomic studies have stimulated synergetic research and development in many cross-disciplinary areas. Processing the vast genomic data, especially the recent large-scale microarray gene expression data, to reveal the complex biological functionality, represents enormous challenges to signal processing and statistics. This perspective naturally leads to a new field, genomic signal processing (GSP), which studies the processing of genomic signals by integrating the theory of signal processing and statistics. Written by an international, interdisciplinary team of authors, this invaluable edited volume is accessible to students just entering this emergent field, and to researchers, both in academia and in industry, in the fields of molecular biology, engineering, statistics, and signal processing. The book provides tutorial-level overviews and addresses the specific needs of genomic signal processing students and researchers as a reference book. The book aims to address current genomic challenges by exploiting potential synergies between genomics, signal processing, and statistics, with special emphasis on signal processing and statistical tools for structural and functional understanding of genomic data. The first part of this book provides a brief history of genomic research and a background introduction from both biological and signal-processing/statistical perspectives, so that readers can easily follow the material presented in the rest of the book. In what follows, overviews of state-of-the-art techniques are provided. We start with a chapter on sequence analysis, and follow with chapters on feature selection, classification, and clustering of microarray data. We then discuss the modeling, analysis, and simulation of biological regulatory networks, especially gene regulatory networks based on Boolean and Bayesian approaches. Visualization and compression of gene data, and supercomputer implementation of genomic signal processing systems are also treated. Finally, we discuss systems biology and medical applications of genomic research as well as the future trends in genomic signal processing and statistics research.
Category: Science

Systems Biology

Author : Aleš Prokop
ISBN : 9789400768031
Genre : Medical
File Size : 75.51 MB
Format : PDF, Docs
Download : 621
Read : 793

Growth in the pharmaceutical market has slowed down – almost to a standstill. One reason is that governments and other payers are cutting costs in a faltering world economy. But a more fundamental problem is the failure of major companies to discover, develop and market new drugs. Major drugs losing patent protection or being withdrawn from the market are simply not being replaced by new therapies – the pharmaceutical market model is no longer functioning effectively and most pharmaceutical companies are failing to produce the innovation needed for success. This multi-authored new book looks at a vital strategy which can bring innovation to a market in need of new ideas and new products: Systems Biology (SB). Modeling is a significant task of systems biology. SB aims to develop and use efficient algorithms, data structures, visualization and communication tools to orchestrate the integration of large quantities of biological data with the goal of computer modeling. It involves the use of computer simulations of biological systems, such as the networks of metabolites comprise signal transduction pathways and gene regulatory networks to both analyze and visualize the complex connections of these cellular processes. SB involves a series of operational protocols used for performing research, namely a cycle composed of theoretical, analytic or computational modeling to propose specific testable hypotheses about a biological system, experimental validation, and then using the newly acquired quantitative description of cells or cell processes to refine the computational model or theory.
Category: Medical

Bioinformatics For Biologists

Author : Pavel Pevzner
ISBN : 9781139501613
Genre : Science
File Size : 25.60 MB
Format : PDF, ePub, Mobi
Download : 396
Read : 341

The computational education of biologists is changing to prepare students for facing the complex datasets of today's life science research. In this concise textbook, the authors' fresh pedagogical approaches lead biology students from first principles towards computational thinking. A team of renowned bioinformaticians take innovative routes to introduce computational ideas in the context of real biological problems. Intuitive explanations promote deep understanding, using little mathematical formalism. Self-contained chapters show how computational procedures are developed and applied to central topics in bioinformatics and genomics, such as the genetic basis of disease, genome evolution or the tree of life concept. Using bioinformatic resources requires a basic understanding of what bioinformatics is and what it can do. Rather than just presenting tools, the authors - each a leading scientist - engage the students' problem-solving skills, preparing them to meet the computational challenges of their life science careers.
Category: Science