Protein Folding Handbook

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Protein Folding Handbook 5 Volume Set

Author : Johannes Buchner
ISBN : 3527307842
Genre : Science
File Size : 69.46 MB
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How a polypeptide chain folds into a stable and functional protein is probably the most important question in present-day molecular biology. Reliably predicting the folding process allows to deduce protein function from genomic information alone and will bring about a revolution in structural genomics. Understanding the way in which proper protein folding is controlled by the cell is required to find a cure for Alzheimer's and other diseases caused by misfolded proteins. This unique handbook contains the expertise from more than 60 research groups, covering the entire range of topics in protein folding - from biophysics to molecular medicine. The first part explains the principles and factors governing protein stability, and how this knowledge may be used to predict folding pathways. It also surveys important techniques used to study the protein folding process, including spectroscopic, chemical and biological techniques. The second part is devoted to protein folding, unfolding, and misfolding in the cellular context, introducing chaperones and other enzymes involved in protein folding, as well as a study of the pathophysiology of misfolded proteins in amyloid and other disease states. The whole is rounded off by a discussion of the possibility of interfering with the protein folding process by genetic engineering. The comprehensiveness and outstanding quality of the carefully selected contents make this the ultimate reference for every scientist with an interest in protein folding.
Category: Science

Guidebook To Molecular Chaperones And Protein Folding Catalysts

Author : Mary-Jane Gething
ISBN : 9780191547270
Genre : Medical
File Size : 62.50 MB
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The precise shape of a protein is a crucial factor in its function. How do proteins become folded into the right conformation? Molecular chaperones and protein folding catalysts bind to developing polypeptides in the cytoplasm and ensure correct folding and transport. This Guidebook catalogues the latest information on nearly 200 of these molecules, including the important class of heat shock proteins; each entry is written by leading researchers in the field.
Category: Medical

Protein Engineering Handbook

Author : Stefan Lutz
ISBN : 9783527667017
Genre : Science
File Size : 34.16 MB
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Unparalleled in size and scope, this new major reference integrates academic and industrial knowledge into a single resource, allowing for a unique overview of the entire field. Adopting a systematic and practice-oriented approach, and including a wide range of technical and methodological information, this highly accessible handbook is an invaluable 'toolbox' for any bioengineer. In two massive volumes, it covers the full spectrum of current concepts, methods and application areas.
Category: Science

Oxidative Folding Of Peptides And Proteins

Author : Luis Moroder
ISBN : 9780854041480
Genre : Science
File Size : 88.60 MB
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The formation of disulfide bonds is probably the most influential modification of peptides and proteins. An elaborate set of cellular machinery exists to catalyze and guide this process. In recent years, significant developments have been made in both our understanding of the in vivo situation and the in vitro manipulation of disulfide bonds. This is the first monograph to provide a comprehensive overview of this exciting and rapidly developing area. It offers in-depth insights into the mechanisms of in vivo and in vitro oxidative folding of proteins as well as mono- and multiple-stranded peptides. Procedures applied for laboratory and industrial purposes are also discussed by top experts in the field. The book describes the enzymes involved in the correct oxidative folding of cysteine-containing proteins in prokaryotes and eukaryotes. It then goes on to discuss the mimicking of these enzymes for successful in vitro folding of proteins (including synthetic replicates) and to deal with important issues concerning cysteine-rich peptides. The ability of natural bioactive peptides to fold correctly, and in high yields, to form defined structural motifs using cysteine sequence patterns is still puzzling. With this in mind, synthetic procedures for establishing native cysteine frameworks are discussed using selected examples, such as the potential of selenocysteines. The biotechnological and pharmaceutical relevance of proteins, peptides, their variants and synthetic replicates is continuously increasing. Consequently, this book is invaluable for peptide and protein chemists involved in related research and production.
Category: Science

Handbook Of Single Molecule Biophysics

Author : Peter Hinterdorfer
ISBN : 0387764976
Genre : Science
File Size : 58.50 MB
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This handbook describes experimental techniques to monitor and manipulate individual biomolecules, including fluorescence detection, atomic force microscopy, and optical and magnetic trapping. It includes single-molecule studies of physical properties of biomolecules such as folding, polymer physics of protein and DNA, enzymology and biochemistry, single molecules in the membrane, and single-molecule techniques in living cells.
Category: Science

Handbook Of Composites From Renewable Materials Structure And Chemistry

Author : Vijay Kumar Thakur
ISBN : 9781119224259
Genre : Technology & Engineering
File Size : 41.78 MB
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The Handbook of Composites From Renewable Materials comprises a set of 8 individual volumes that brings an interdisciplinary perspective to accomplish a more detailed understanding of the interplay between the synthesis, structure, characterization, processing, applications and performance of these advanced materials. The handbook covers a multitude of natural polymers/ reinforcement/ fillers and biodegradable materials. Together, the 8 volumes total at least 5000 pages and offers a unique publication. Volume 1 is solely focused on the Structure and Chemistry of renewable materials. Some of the important topics include but not limited to: carbon fibers from sustainable resources; polylactic acid composites and composite foams based on natural fibres; composites materials from other than cellulosic resources; microcrystalline cellulose and related polymer composites; tannin-based foam; renewable feedstock vanillin derived polymer and composites; silk biocomposites; bio-derived adhesives and matrix polymers; biomass based formaldehyde-free bio-resin ; isolation and characterization of water soluble polysaccharide; bio-based fillers; keratin based materials in biotechnology; structure of proteins adsorbed onto bioactive glasses for sustainable composite; effect of filler properties on the antioxidant response of starch composites; composite of chitosan and its derivate; magnetic biochar from discarded agricultural biomass; biodegradable polymers for protein and peptide conjugation; polyurethanes and polyurethane composites from bio-based / recycled components.
Category: Technology & Engineering

Handbook Of Physics In Medicine And Biology

Author : Robert Splinter
ISBN : 9781420075250
Genre : Science
File Size : 67.87 MB
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In considering ways that physics has helped advance biology and medicine, what typically comes to mind are the various tools used by researchers and clinicians. We think of the optics put to work in microscopes, endoscopes, and lasers; the advanced diagnostics permitted through magnetic, x-ray, and ultrasound imaging; and even the nanotools, that allow us to tinker with molecules. We build these instruments in accordance with the closest thing to absolute truths we know, the laws of physics, but seldom do we apply those same constants of physics to the study of our own carbon-based beings, such as fluidics applied to the flow of blood, or the laws of motion and energy applied to working muscle. Instead of considering one aspect or the other, Handbook of Physics in Medicine and Biology explores the full gamut of physics’ relationship to biology and medicine in more than 40 chapters, written by experts from the lab to the clinic. The book begins with a basic description of specific biological features and delves into the physics of explicit anatomical structures starting with the cell. Later chapters look at the body's senses, organs, and systems, continuing to explain biological functions in the language of physics. The text then details various analytical modalities such as imaging and diagnostic methods. A final section turns to future perspectives related to tissue engineering, including the biophysics of prostheses and regenerative medicine. The editor’s approach throughout is to address the major healthcare challenges, including tissue engineering and reproductive medicine, as well as development of artificial organs and prosthetic devices. The contents are organized by organ type and biological function, which is given a clear description in terms of electric, mechanical, thermodynamic, and hydrodynamic properties. In addition to the physical descriptions, each chapter discusses principles of related clinical diagnostic methods and technological aspects of therapeutic applications. The final section on regenerative engineering, emphasizes biochemical and physiochemical factors that are important to improving or replacing biological functions. Chapters cover materials used for a broad range of applications associated with the replacement or repair of tissues or entire tissue structures.
Category: Science

Handbook Of Molecular Force Spectroscopy

Author : Aleksandr Noy
ISBN : 9780387499895
Genre : Science
File Size : 38.80 MB
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Researchers in academia and industry who are interested in techniques for measuring intermolecular forces will find this an essential text. It presents a review of modern force spectroscopy, including fundamentals of intermolecular forces, technical aspects of the force measurements, and practical applications. The handbook begins with a review of the fundamental physics of loading single and multiple chemical bonds on the nanometer scale. It contains a discussion of thermodynamic and kinetic models of binding forces and dissipation effects in nanoscale molecular contacts, covers practical aspects of modern single-molecule level techniques, and concludes with applications of force spectroscopy to chemical and biological processes. Computer modeling of force spectroscopy experiments is also addressed.
Category: Science

Handbook Of Cancer Vaccines

Author : Michael A. Morse
ISBN : 9781592596805
Genre : Medical
File Size : 44.86 MB
Format : PDF
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An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.
Category: Medical

The G Protein Coupled Receptors Handbook

Author : Lakshmi A. Devi
ISBN : 1592599192
Genre : Medical
File Size : 70.92 MB
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A comprehensive survey of the many recent advances in the field of G protein-coupled receptors (GPCR). The authors describe the current knowledge of GPCR receptor structure and function, the different mechanisms involved in the regulation of GPCR function, and the role of pharmacological chaperones in GPCR folding and maturation. They also present new findings about how GPCR dimerization/oligomerization modifies the properties of individual receptors and show how recent developments are leading to significant advances in drug discovery, such as the detection of ligands for orphan GPCRs. Also discussed are the most recent developments that could lead to new drug discoveries: the role of GPCRs in mediating pain, the development of receptor-type selective drugs based on the structural plasticity of receptor activation, and the identification of natural ligands of orphan GPCRs (deorphanization) as possible drug targets.
Category: Medical

Handbook Of Spectroscopy

Author : G¿nter Gauglitz
ISBN : 9783527654727
Genre : Science
File Size : 37.71 MB
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This second, thoroughly revised, updated and enlarged edition provides a straightforward introduction to spectroscopy, showing what it can do and how it does it, together with a clear, integrated and objective account of the wealth of information that may be derived from spectra. It also features new chapters on spectroscopy in nano-dimensions, nano-optics, and polymer analysis. Clearly structured into sixteen sections, it covers everything from spectroscopy in nanodimensions to medicinal applications, spanning a wide range of the electromagnetic spectrum and the physical processes involved, from nuclear phenomena to molecular rotation processes. In addition, data tables provide a comparison of different methods in a standardized form, allowing readers to save valuable time in the decision process by avoiding wrong turns, and also help in selecting the instrumentation and performing the experiments. These four volumes are a must-have companion for daily use in every lab.
Category: Science

The Integrated Approach To Chemistry Laboratory

Author : Partha Basu
ISBN : 9781932078886
Genre : Education
File Size : 51.27 MB
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This book features complete and original labs for the integrated laboratory. All materials, protocols, and equipment are spelled out. Each lab is customizable for your department. The book introduces and explains a wide range of lab techniques, and is geared to various ability levels. This volume is intended for chemistry instructors seeking to provide engaging and challenging labs that combine all the features and benefits of the integrated laboratory. Written by educators from around the country, each chapter of the book contains a fully detailed and explained experiment, with guidance for student questions and possible customization. The book offers students and instructors a wealth of learning opportunities in experiment preparation, measurement, recording and analysis from disciplines extending from biology and microbiology to geology, nanotechnology, and microelectronics. All experiments have been classroom tested, with safety and monitoring issues given precedence. Many of the experiments contain modules that permit the instructor to make the lab more challenging as time and student ability dictate.
Category: Education

The Porphyrin Handbook

Author : Roger Guilard
ISBN : 9780080923857
Genre : Science
File Size : 33.92 MB
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The Porphyrin Handbook, Volume 11: Bioinorganic and Bioorganic Chemistry presents the fundamental aspects of the synthesis, structure, chemistry, and spectroscopy of phthalocyanines. This book discusses the biology and medical implications of porphyrin systems. Organized into seven chapters, this volume begins with an overview of the design, synthesis, and study of the structural and functional models of heme/copper terminal oxidases. This text then examines the proteins containing iron-protoporphyrin IX (heme), which play key roles in photosynthesis and respiration. Other chapters consider the syntheses of chiral porphyrin derivatives and summarize the uses of such compounds in enantioselective control. This book discusses as well the reactivity and synthesis of synthetic carbine metalloporphyrins. The final chapter deals with the B12-coenzymes, which is the most complex and physiologically important organometallic enzymatic reactions that directly depend on the reactivity of metal coordinated organic ligands. This book is a valuable resource for research scientists, clinicians, and engineers.
Category: Science

The Handbook Of Nanomedicine

Author : Kewal K. Jain
ISBN : 1603273190
Genre : Science
File Size : 31.91 MB
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This handbook covers the broad scope of nanomedicine. Starting with the basics, the subject is developed to potential clinical applications, many of which are still at an experimental stage. The book features extensive coverage of nanodiagnostics and nanopharmaceuticals, which are two important components of nanomedicine. Written by a physician-scientist author who blends his clinical experience and scientific expertise in new technologies, this book provides a definitive account of nanomedicine. It offers more up-to-date and comprehensive coverage of nanomedicine than any other comparable work.
Category: Science

The Phylogenetic Handbook

Author : Marco Salemi
ISBN : 052180390X
Genre : Computers
File Size : 74.51 MB
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Sample Text
Category: Computers

Mass Spectrometry Handbook

Author : Mike S. Lee
ISBN : 9781118180723
Genre : Science
File Size : 56.17 MB
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Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.
Category: Science

Handbook Of Nanoscience Engineering And Technology

Author : William A. Goddard III
ISBN : 142000784X
Genre : Science
File Size : 22.75 MB
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The ability to study and manipulate matter at the nanoscale is the defining feature of 21st-century science. The first edition of the standard-setting Handbook of Nanoscience, Engineering, and Technology saw the field through its infancy. Reassembling the preeminent team of leading scientists and researchers from all areas of nanoscience and nanote
Category: Science

The Proteomics Protocols Handbook

Author : John M. Walker
ISBN : 9781588293435
Genre : Medical
File Size : 59.45 MB
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Hands-on researchers describe in step-by-step detail a wide range of proven laboratory methods and bioinformatics tools essential for analysis of the proteome. These cutting-edge techniques (73 in all) addresses such important tasks as sample preparation, 2D-PAGE, gel staining, protein expression profiling, identifying protein-protein interactions, and protein chip tehcnology, as well as a range of newly developed methodologies for determing the structure and function of a protein, including novel mass spectrometry and LC-MS techniques, protein array technology, and a variety of structural and functional proteomics techniques needed to determine the function of newly discovered protein sequences.
Category: Medical