Pharmacokinetics And Metabolism In Drug Design

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Pharmacokinetics And Metabolism In Drug Design

Author : Dennis A. Smith
ISBN : 9783527329540
Genre : Medical
File Size : 59.65 MB
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In this new edition of a bestseller, all the contents have been brought upto-date by addressing current standards and best practices in the assessment and prediction of ADMET properties. Although the previous chapter layout has been retained, substantial revisions have been made, with new topics such as pro-drugs, active metabolites and transporters covered in detail in a manner useful to the Drug Discovery scientist. The authors discuss the parameters and processes important for the absorption, distribution and retention of drug compounds in the body, plus the potential problems created by their transformation into toxic byproducts. While aimed at all those dealing professionally with the development and application of pharmaceutical substances, the readily comprehensible style makes this book equally suitable for students of pharmacy and related subjects. Uniquely comprehensive, the book relates physicochemistry and chemical structure to pharmacokinetic properties and ultimately drug efficacy and safety.
Category: Medical

A Handbook Of Bioanalysis And Drug Metabolism

Author : Gary Evans
ISBN : 0203642538
Genre : Medical
File Size : 22.77 MB
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Recent years have seen a greater industrial emphasis in undergraduate and postgraduate courses in the pharmaceutical and chemical sciences. However, textbooks have been slow to adapt, leaving the field without a text/reference that is both instructional and practical in the industrial setting – until now. A Handbook of Bioanalysis and Drug Metabolismis a stimulating new text that examines the techniques, methodology, and theory of bioanalysis, pharmacokinetics, and metabolism from the perspective of scientists with extensive professional experience in drug discovery and development. These three areas of research help drug developers to optimize the active component within potential drugs thereby increasing their effectiveness, and to provide safety and efficacy information required by regulators when granting a drug license. Professionals with extensive experience in drug discovery and development as well as specialized knowledge of the individual topics contributed to each chapter to create a current and well-credentialed text. It covers topics such as high performance liquid chromatography, protein binding, pharmacokinetics and drug–drug interactions. The unique industrial perspective helps to reinforce theory and develop valuable analytical and interpreting skills. This text is an invaluable guide to students in courses such as pharmaceutical science, pharmacology, chemistry, physiology and toxicology, as well as professionals in the biotechnology industry.
Category: Medical

Research Awards Index

Author :
ISBN : STANFORD:36105119623713
Genre : Medicine
File Size : 46.84 MB
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Category: Medicine

Advanced Methods Of Pharmacokinetic And Pharmacodynamic Systems Analysis

Author : David D'Argenio
ISBN : 9780306485237
Genre : Medical
File Size : 82.96 MB
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Advanced Methods of Pharmacokinetic and Pharmocodynamic Systems Analysis Volume 3 is vital to professionals and academicians working in drug development and bioengineering. Both basic and clinical scientists will benefit from this work. This book contains chapters by leading researchers in pharmacokinetic/pharmacodynamic modeling and will be of interest to anyone involved with the application of pharmacokinetic and pharmacodynamics to drug development. The use of mathematical modeling and associated computational methods is central to the study of the absorption, distribution and elimination of therapeutic drugs (pharmacokinetics) and to understanding how drugs produce their effects (pharmacodynamics). From its inception, the field of pharmacokinetics and pharmacodynamics has incorporated methods of mathematical modeling, simulation and computation in an effort to better understand and quantify the processes of uptake, disposition and action of therapeutic drugs. These methods for pharmacokinetic/pharmacodynamic systems analysis impact all aspects of drug development. In vitro, animal and human testing, as well as drug therapy are all influenced by these methods. Modeling methodologies developed for studying pharmacokinetic/ pharmacodynamic processes confront many challenges. This is related in part to the severe restrictions on the number and type of measurements that are available from laboratory experiments and clinical trials, as well as the variability in the experiments and the uncertainty associated with the processes themselves. The contributions are organized in three main areas: Mechanism-Based PK/PD, Pharmacometrics and Pharmacotherapy. Both professionals and academics will profit from this extensive work.
Category: Medical

Metabolite Safety In Drug Development

Author : Suzanne L. Iverson
ISBN : 9781118949658
Genre : Medical
File Size : 86.81 MB
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A reference on drug metabolism and metabolite safety in the development phase, this book reviews the analytical techniques and experimental designs critical for metabolite studies. It features case studies of lessons learned and real world examples, along with regulatory perspectives from the US FDA and EMA. • Reviews the analytical techniques and experimental designs critical for metabolite studies • Covers methods including chirality, species differences, mass spectrometry, radiolabels, and in vitro / in vivo correlation • Discusses target pharmacology, in vitro systems aligned to toxicity tests, and drug-drug interactions • Includes perspectives from authors with firsthand involvement in industry and the study of drug metabolites, including viewpoints that have influenced regulatory guidelines
Category: Medical

Pharmacokinetics In Drug Development

Author : Peter L. Bonate
ISBN : 1441979379
Genre : Medical
File Size : 61.97 MB
Format : PDF
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The topics chosen for this volume were selected because they are some of the current development or technological issues facing drug development project teams. They regard the practical considerations for assessment of selected special development populations. For example, they include characterization of drug disposition in pregnant subjects, for measuring arrhythmic potential, for analysis tumor growth modeling, and for disease progression modeling. Practical considerations for metabolite safety testing, transporter assessments, Phase 0 testing, and development and execution of drug interaction programs reflect current regulatory topics meant to address enhancement of both safety assessment and early decision-making during new candidate selection. Important technologies like whole body autoradiography, digital imaging and dried blood spot sample collection methods are introduced, as both have begun to take a more visible role in pharmacokinetic departments throughout the industry.
Category: Medical

Metabolism Pharmacokinetics And Toxicity Of Functional Groups

Author : Dennis A. Smith
ISBN : 9781849730167
Genre : Medical
File Size : 79.71 MB
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Written by medicinal chemists and ADMET scientists with a combined experience of over 300 years this aid to discovering drugs provides detailed coverage on absorption, distribution, metabolism, excretion and toxicology issues associated with new drugs.
Category: Medical

Xenobiotica

Author :
ISBN : UCLA:L0067453043
Genre : Biochemistry
File Size : 72.96 MB
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Category: Biochemistry

Drug Metabolism In Drug Design And Development

Author : Donglu Zhang
ISBN : 0470191686
Genre : Science
File Size : 43.68 MB
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The essentials of drug metabolism vital to developing new therapeutic entities Information on the metabolism and disposition of candidate drugs is a critical part of all aspects of the drug discovery and development process. Drug metabolism, as practiced in the pharmaceutical industry today, is a complex, multidisciplinary field that requires knowledge of sophisticated analytical technologies and expertise in mechanistic and kinetic enzymology, organic reaction mechanism, pharmacokinetic analysis, animal physiology, basic chemical toxicology, preclinical pharmacology, and molecular biology. With chapters contributed by experts in their specific areas, this reference covers: * Basic concepts of drug metabolism * The role of drug metabolism in the pharmaceutical industry * Analytical techniques in drug metabolism * Common experimental approaches and protocols Drug Metabolism in Drug Design and Development emphasizes practical considerations such as the data needed, the experiments and analytical methods typically employed, and the interpretation and application of data. Chapters highlight facts, common protocols, detailed experimental designs, applications, and limitations of techniques. This is a comprehensive, hands-on reference for drug metabolism researchers as well as other professionals involved in pre-clinical drug discovery and development.
Category: Science

Pharmacokinetics

Author : Peter G. Welling
ISBN : STANFORD:36105110341216
Genre : Medical
File Size : 79.30 MB
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Pharmacokinetics is the study of the absorption, distribution, metabolism, and excretion of drugs in humans. This book, written by an internationally known researcher, teaches the basic principles, including drug transport, parenteral and enteral routes of drug administration, and factors affecting drug absorption, distribution, and metabolism. Extensively revised, this edition presents the mathematics of pharmacokinetics with various single- and multi-compartment models including detailed descriptions of metabolite and nonlinear pharmacokinetics. It also describes renal and hepatic drug clearance, and the influence of kidney and liver impairment on these functions. Taking a tutorial approach throughout, the author provides both a clear introduction to pharmacokinetics and a critical look at how this science affects drug discovery and development.
Category: Medical

New Drug Development

Author : Mark P. Mathieu
ISBN : UOM:39015052542779
Genre : Drugs
File Size : 29.32 MB
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Category: Drugs

Comprehensive Medicinal Chemistry

Author : Corwin Hansch
ISBN : UOM:49015003038834
Genre : Cell membrane
File Size : 24.15 MB
Format : PDF
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Drug design is a multi-disciplinary activity involving chemists, biologists, bochemists, mpharmacologists and many others. the chemist's role is central in inventing new compounds which exert a beneficial effect. However, once a lead for a new active drug has been established, its effective delivery has to be demonstrated and extensive toxikological studies undertaken to demonstrate its safety before cinical trials can commence. The metabolic fate of the drug has to be revealed and detailed distribution studies carried out in order to satisfy the regulatory authorities before the new compound can be marketed. Comprehensive Medicinal Chemistry describes all these aspects of the design of a drug whilst centering on the chemical mechanism whereby such agents act. Volume 3 describes membranes and receptors.
Category: Cell membrane