Parasitic Protozoa V9

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Mechanisms Of Epithelial Defense

Author : Dieter Kabelitz
ISBN : 9783805578622
Genre : Medical
File Size : 87.3 MB
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Annotation Epithelial defense against infectious agents relies on the recognition of microbial products by pattern recognition receptors and the local production of antimicrobial peptides. This book provides a state-of-the-art overview of the basic characteristics and clinical relevance of antimicrobial peptides, with special emphasis on their role in skin, intestinal and lung inflammation. The evolutionary significance of antimicrobial peptides is highlighted by an in-depth analysis of their structure, activity and gene regulation in Drosophila melanogaster. Toll-like receptors are an important class of pattern recognition receptors, whose roles in recognizing bacterial molecular patterns and in the intracellular signalling pathways involved in the differentiation and function of dendritic cells are discussed. Finally, this book also addresses the role of intraepithelial lympho cytes in epithelial defense, notably of T cells which form a link between innate and adaptive immune responses. The combined analysis of epithelial and lymphoid cells and effector mechanisms sheds new light on the epithelial defense system in physiological and pathophysiological conditions. Immunologists, dermatologists, microbiologists, and infectious disease specialists will greatly benefit from the wealth of new findings presented by leading investigators.
Category: Medical

Parasite Diversity And Diversification

Author : Serge Morand
ISBN : 9781107037656
Genre : Science
File Size : 88.9 MB
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By joining phylogenetics and evolutionary ecology, this book explores the patterns of parasite diversity while revealing diversification processes.
Category: Science

Protein Phosphorylation In Health And Disease

Author : Allegra Via
ISBN : 9782889199006
Genre :
File Size : 23.79 MB
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Protein phosphorylation is one of the most abundant reversible post-translational modifications in eukaryotes. It is involved in virtually all cellular processes by regulating protein function, localization and stability and by mediating protein-protein interactions. Furthermore, aberrant protein phosphorylation is implicated in the onset and progression of human diseases such as cancer and neurodegenerative disorders. In the last years, tens of thousands of in vivo phosphorylation events have been identified by large-scale quantitative phospho-proteomics experiment suggesting that a large fraction of the proteome might be regulated by phosphorylation. This data explosion is increasingly enabling the development of computational approaches, often combined with experimental validation, aiming at prioritizing phosphosites and assessing their functional relevance. Some computational approaches also address the inference of specificity determinants of protein kinases/phosphatases and the identification of phosphoresidue recognition domains. In this context, several challenging issues are still open regarding phosphorylation, including a better understanding of the interplay between phosphorylation and allosteric regulation, agents and mechanisms disrupting or promoting abnormal phosphorylation in diseases, the identification and modulation of novel phosphorylation inhibitors, and so forth. Furthermore, the determinants of kinase and phosphatase recognition and binding specificity are still unknown in several cases, as well as the impact of disease mutations on phosphorylation-mediated signaling. The articles included in this Research Topic illustrate the very diverse aspects of phosphorylation, ranging from structural changes induced by phosphorylation to the peculiarities of phosphosite evolution. Some also provide a glimpse into the huge complexity of phosphorylation networks and pathways in health and disease, and underscore that a deeper knowledge of such processes is essential to identify disease biomarkers, on one hand, and design more effective therapeutic strategies, on the other.
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The Cumulative Book Index

Author :
ISBN : UOM:39015058373955
Genre : American literature
File Size : 85.97 MB
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A world list of books in the English language.
Category: American literature

Book Review Index

Author :
ISBN : UOM:39015064548640
Genre : Books
File Size : 30.54 MB
Format : PDF
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Every 3rd issue is a quarterly cumulation.
Category: Books

Genetics Abstracts

Author :
ISBN : UOM:39015053938448
Genre : Genetics
File Size : 22.32 MB
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Category: Genetics

Marine Protists

Author : Susumu Ohtsuka
ISBN : 9784431551300
Genre : Science
File Size : 20.81 MB
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This comprehensive book provides a unique overview of advances in the biology and ecology of marine protists. Nowadays marine protistology is a hot spot in science to disclose life phenomena using the latest techniques. Although many protistological textbooks deal with the cytology, genetics, ecology, and pathology of specific organisms, none keeps up with the quick pace of new discoveries on the diversity and dynamics of marine protists in general. The bookMarine Protists: Diversity and Dynamics gives an overview of current research on the phylogeny, cytology, genomics, biology, ecology, fisheries, applied sciences, geology and pathology of marine free-living and symbiotic protists. Poorly known but ecologically important protists such as labyrinthulids and apostome ciliates are also presented in detail. Special attention is paid to complex interactions between marine protists and other organisms including human beings. An understanding of the ecological roles of marine protists is essential for conservation of nature and human welfare. This book will be of great interest not only to scientists and students but also to a larger audience, to give a better understanding of protists’ diverse roles in marine ecosystems.
Category: Science

Oceanic Abstracts

Author :
ISBN : UVA:X006072910
Genre : Marine biology
File Size : 76.37 MB
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Category: Marine biology