One Renegade Cell

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One Renegade Cell

Author : Robert A Weinberg
ISBN : 9781780227788
Genre : Science
File Size : 30.48 MB
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How cancers begin and spread, by the scientist responsible for the major recent research breakthroughs Cancer research has reached a major turning point. The amount of information gathered in the past twenty years about the origins of the disease is without equal in the history of biomedical research. In this book one of America's most eminent scientists explains to the general reader the step-by-step process by which cancers arise, and more importantly, how they spread. Robert Weinberg explains how normal genes control the conventional growth of the cell, how, in their mutated form, they enable cancers to arise, and why these genes have such life-and-death power over us. Drawing from information that simply was not available until recently, One Renegade Cell explains this insidious disease as no other book as ever been able to do.
Category: Science

One Renegade Cell

Author : Robert Allan Weinberg
ISBN : 0297816454
Genre : Cancer
File Size : 89.83 MB
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Category: Cancer

The Society Of Genes

Author : Itai Yanai
ISBN : 9780674915961
Genre : Science
File Size : 47.69 MB
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Since Dawkins popularized the notion of the selfish gene, the question of how these selfish genes work together to construct an organism remained a mystery. Now, standing atop a wealth of new research, Itai Yanai and Martin Lercher—pioneers in the field of systems biology—provide a vision of how genes cooperate and compete in the struggle for life.
Category: Science

Philosophy Of Cancer

Author : Marta Bertolaso
ISBN : 9789402408652
Genre : Philosophy
File Size : 20.34 MB
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Since the 1970s, the origin of cancer is being explored from the point of view of the Somatic Mutation Theory (SMT), focusing on genetic mutations and clonal expansion of somatic cells. As cancer research expanded in several directions, the dominant focus on cells remained steady, but the classes of genes and the kinds of extra-genetic factors that were shown to have causal relevance in the onset of cancer multiplied. The wild heterogeneity of cancer-related mutations and phenotypes, along with the increasing complication of models, led to an oscillation between the hectic search of ‘the’ few key factors that cause cancer and the discouragement in face of a seeming ‘endless complexity’. To tame this complexity, cancer research started to avail itself of the tools that were being developed by Systems Biology. At the same time, anti-reductionist voices began claiming that cancer research was stuck in a sterile research paradigm. This alternative discourse even gave birth to an alternative theory: the Tissue Organization Field Theory (TOFT). A deeper philosophical analysis shows limits and possibilities of reductionist and anti-reductionist positions and of their polarization. This book demonstrates that a radical philosophical reflection is necessary to drive cancer research out of its impasses. At the very least, this will be a reflection on the assumptions of different kinds of cancer research, on the implications of what cancer research has been discovering over 40 years and more, on a view of scientific practice that is most able to make sense of the cognitive and social conflicts that are seen in the scientific community (and in its results), and, finally, on the nature of living entities with which we entertain this fascinating epistemological dance that we call scientific research. The proposed Dynamic and Relational View of carcinogenesis is a starting point in all these directions.
Category: Philosophy

One In Three

Author : Adam Wishart
ISBN : 9781555848873
Genre : Health & Fitness
File Size : 69.8 MB
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How close are we to defeating cancer? A “calming and illuminating” blend of memoir and medical history (Janet Maslin, The New York Times). When his father was diagnosed with cancer, documentary filmmaker Adam Wishart couldn’t find a book that clearly answered his most basic questions: What was the disease and how did it take hold? What is it about cancer’s biology that makes it hard to eradicate? And most importantly, are we on the way to a cure? One in Three is both a son’s personal story and a journalistic take on cancer’s history, outlining the encouraging story of science’s progress in changing the outlook on cancer from a disease we die from to one we live with. Covering the discovery of the disease, its treatment, and its prevention, this is a story of both hardship and hope, and a helpful companion for anyone dealing with this all too common illness as a patient, a loved one, or a caregiver. “An engaging presentation of facts reported with the cool detachment of a professional journalist interspersed with the raw feelings of a son recording the progress of his father’s fatal illness, what’s right and wrong within the medical community, and the emotional toll on everyone involved with the father and son’s journey.” —Booklist “Fascinating.” —San Francisco Chronicle “Makes abstract science accessible and dignifies a human story with the insights of medicine.” —Andrew Solomon, New York Times–bestselling and National Book Award–winning author of Far from the Tree
Category: Health & Fitness

The Cancer Chronicles

Author : George Johnson
ISBN : 9780385349710
Genre : Medical
File Size : 53.85 MB
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When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease. Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body. Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.
Category: Medical

Molecular Pathology Of Hematolymphoid Diseases

Author : Cherie H. Dunphy
ISBN : 1441956980
Genre : Medical
File Size : 20.49 MB
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The past two decades have seen an ever-accelerating growth in knowledge about molecular pathology of human diseases, which received a large boost with the sequencing of the human genome in 2003. Molecular diagnostics, molecular targeted therapy and genetic therapy, are now routine in many medical centers. The molecular field now impacts every field in medicine, whether clinical research or routine patient care. There is a great need for basic researchers to understand the potential clinical implications of their research whereas private practice clinicians of all types (general internal medicine and internal medicine specialists, me- cal oncologists, radiation oncologists, surgeons, pediatricians, family practitioners), clinical investigators, pathologists and medical laboratory directors and radiologists require a basic understanding of the fundam- tals of molecular pathogenesis, diagnosis, and treatment for their patients. Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical s- ting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is an urgent need for a text that fills the gap between basic science books and clinical practice. In the Molecular Pathology Library series, the basic science and the technology is integrated with the medical perspective and clinical application.
Category: Medical

Problems To Go Problems To Solve

Author : Dominic W. Moreo
ISBN : 9781475906219
Genre : Social Science
File Size : 59.77 MB
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Louis Pasteur put succinctly the task of this book, to wit, "...chance favors the prepared mind." To that end, this work contributes to the mental wallpapers that facilitate problem solving by any individual, student or adult, of contemporary events. Problem solving feeds on its own success and makes society and the world appear less intractable, less chaotic to human intervention.
Category: Social Science

Human Social Evolution

Author : Kyle Summers
ISBN : 9780199339631
Genre : Science
File Size : 55.6 MB
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Richard D. Alexander is an accomplished entomologist who turned his attention to solving some of the most perplexing problems associated with the evolution of human social systems. Using impeccable Darwinian logic and elaborating, extending and adding to the classic theoretical contributions of pioneers of behavioral and evolutionary ecology like George Williams, William Hamilton and Robert Trivers, Alexander developed the most detailed and comprehensive vision of human social evolution of his era. His ideas and hypotheses have inspired countless biologists, anthropologists, psychologists and other social scientists to explore the evolution of human social behavior in ever greater detail, and many of his seminal ideas have stood the test of time and come to be pillars of our understanding of human social evolution. This volume presents classic papers or chapters by Dr. Alexander, each focused on an important theme from his work. Introductions by Dr. Alexander's former students and colleagues highlight the importance of his work to the field, describe more recent work on the topic, and discuss current issues of contention and interest.
Category: Science

My Cancer Is Me

Author : Vijay Bhat
ISBN : 9789381398340
Genre : Self-Help
File Size : 59.30 MB
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The inspiring story of one man’s relationship with his cancer and how it healed him . . . ‘You have cancer.’ These simple words come as a terrible shock. Life, as you know it, changes in an instant and nothing is the same again. Panic and fear overwhelm you as you desperately pin your hopes on doctors and on medical treatment. But this is only part of the story. While your doctors work towards healing your body, you must heal your inner self, just as Vijay Bhat did to beat his cancer. When he focused on himself, Vijay realized that his cancer originated within and only then manifested as a ‘tumour’ in his body. The authors believe that healing requires a ‘person-centric’ approach, where the focus is the whole person and all the aspects of his inner and outer life, rather than an ‘organ-centric’ one, where the focus is merely the disease or affected organ. According to them, cancer is the result of your physical lifestyle along with your mental, emotional and spiritual processes and the ‘stressors’ associated with these processes. For instance, negative thoughts and attitudes are mental stressors while negative emotions such as anger and guilt are emotional stressors. Healing these aspects of yourself is essential for physical healing. The authors guide you through your process of self-discovery, showing you how to find your stressors and teaching you how to recover from them. The book also gives useful information on the biological aspects of cancer and its causes; dietary and nutritional needs of cancer patients; how to maintain optimum immunity; how to confront loss and death; and the role of the caregiver. My Cancer Is Me is a thought-provoking and sensitive guide for anyone who has cancer or is supporting a loved one with cancer.
Category: Self-Help

Status Syndrome

Author : Michael Marmot
ISBN : 9781408834190
Genre : Science
File Size : 59.36 MB
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Why do Oscar winners live for an average of four years longer than other Hollywood actors? Who experiences the most stress - the decision-makers or those who carry out their orders? Why do the Japanese have better health than other rich populations, and Keralans in India have better health than other poor populations - and what do they have in common? In this eye-opening book, internationally renowned epidemiologist Michael Marmot sets out to answer these and many other fascinating questions in order to understand the relationship between where we stand in the social hierarchy and our health and longevity. It is based on more than thirty years of front-line research between health and social circumstances. Marmot's work has taken him round the world showing the similar patterns that could be affecting the length of your life - and how you can change it.
Category: Science

The Doomsday Calculation

Author : G. A. Mohr
ISBN : 9781479719105
Genre : Philosophy
File Size : 60.79 MB
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The Doomsday Calculation The End of the Human Race Our present population is at least twice that sustainable, resulting in excessive consumption, resource depletion, the energy crisis, pollution, global warming, environmental destruction, and evolution of new diseases. We face economic collapse and increasing war and terrorism. Causes of our problems include incompetent leadership in politics and business, corrupt capitalism, globalization, megacities built around cars, junk products and the bullshit and brainwashing used in religion, politics and business. Unless we take drastic action to deal with our critical situation the earth will be so ravaged by environmental destruction, pollution, and climate change that we will be reduced to a subsistence existence or made extinct altogether like the 50% of animal species expected to disappear in the next 200 years. Industry and reader comment has included: Some provocative and timely issues. A huge topic. A prophetic warning This should be our bible.
Category: Philosophy

Tackling Cancer

Author : Rosen Pub. (NA)
ISBN : 1404209875
Genre : Juvenile Nonfiction
File Size : 84.14 MB
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A collection of articles examining some of the latest work in the understanding and treatment of cancer.
Category: Juvenile Nonfiction

New Scientist

Author :
ISBN : UCSD:31822022788129
Genre : Science
File Size : 59.51 MB
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Category: Science

John Donne Journal

Author :
ISBN : UCSD:31822036572824
Genre : English literature
File Size : 31.81 MB
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Category: English literature

Cells Tissues And Disease

Author : Guido Majno
ISBN : UOM:39015059148034
Genre : Medical
File Size : 89.49 MB
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This book lays out the principles of general pathology for biomedical researchers, grad students, medical students, and physicians, with elegance and deep insight. Disease processes are explained in the light of malfunctions at the cellular level, offering a rich understanding of the clinical correlates of all aspects of fundamental cellular physiology and basic biomedicine. The book has been fully revised and updated to present a current but deep understanding of disease states at the cell and tissue levels - cellular pathology, inflammation, immunopathology vascular disturbance, and tumor biology.
Category: Medical

Newsweek

Author :
ISBN : UOM:39015079684943
Genre : Current events
File Size : 40.63 MB
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Category: Current events

Cancer Biotherapy

Author : Annie Young
ISBN : UOM:39015063179462
Genre : Medical
File Size : 78.72 MB
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Recent advances in biology and immunology have opened up new horizons in both our understanding of cancer as a disease, and the potential for cancer therapy. These major developments mean that chemotherapy, radiotherapy and surgery are no longer the only options. Biotherapy, or biological therapy, is now regarded as the fourth treatment modality for patients with cancer. It utilises the great increase in our knowledge of molecular biology, cell biology and immunology to achieve tumour control. New biological agents are currently being used to treat cancer, such as monoclonal antibodies and vaccine therapies to stimulate the body's immune system to attack cancer cells. Biotherapy may be targeted to act specifically on cancer cells. Drugs such as monoclonal antibodies can be designed to recognize and find a particular type of cancer cell, attach itself to them, and destroy them. Naturally occuring biological molecules such as cytokines are also used, and the manipulation of normal biological mechanisms to control or inhibit tumour growth is another key feature of biotherapy. Edited by a team with perspectives in pharmacology, oncology and nursing, and with contributions from experts in the various areas of biotherapy, this book serves as an introduction to the subject. It includes the principles behind biological therapy, with discussion of the impact on the future of the fight against cancer. It has a strong clinical focus, describing the relevant biology and immunology while highlighting clinical relevance and treatment issues.
Category: Medical

Renegade Regimes

Author : Miroslav Nincic
ISBN : 9780231510295
Genre : Political Science
File Size : 57.8 MB
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Rogue states pursue weapons of mass destruction, support terrorism, violate human rights, engage in acts of territorial aggression, and pose a threat to the international community. Recent debates and policy shifts regarding Iraq, North Korea, Syria, Iran, and Afghanistan reflect the uneven attempts to contend with regimes that pursue deviant behavior. In this timely new work, Miroslav Nincic illuminates the complex issues and policy choices surrounding clashes between international society and states that challenge the majority's espoused interests and values. As conventional approaches to international relations lose their relevance in a changing world, Nincic's work provides new and necessary frameworks and perspectives. Nincic explores recent events and develops theoretical models of contemporary asymmetrical power relations among states to offer a systematic account of the genesis, trajectory, and motivations of renegade regimes. He discusses how the pursuit of policies that defy international norms is often motivated by a regime's desire for greater domestic control. From this starting point, Nincic considers states' deviant behavior through two stages: the first is the initial decision to defy key aspects of the international normative order, and the second is the manner in which subsequent behavior is shaped by the international community's responses. In addressing attempts to control pariah states, Nincic assesses the effectiveness of sanctions and military responses. He provocatively argues that comprehensive economic sanctions can lead to a restructuring of the renegade regime's ideology and economy that ultimately strengthens its grip on power. In his chapter on military intervention, Nincic argues that force or the threat of force against a rogue state frequently triggers a protective reflex among its citizens, inspiring them to rally around the government's goals and values. Military threats, Nincic concludes, produce several kinds of consequences and their impact needs to be better understood.
Category: Political Science