Nucleic Acids

Download Nucleic Acids ebook PDF or Read Online books in PDF, EPUB, and Mobi Format. Click Download or Read Online button to Nucleic Acids book pdf for free now.

Nucleic Acids In Chemistry And Biology

Author : G Michael Blackburn
ISBN : 9781782625773
Genre : Science
File Size : 66.57 MB
Format : PDF, Mobi
Download : 472
Read : 586

The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.
Category: Science

Nucleic Acids

Author : Victor A. Bloomfield
ISBN : 0935702490
Genre : Science
File Size : 31.45 MB
Format : PDF
Download : 406
Read : 425

NucleicAcids presents an up-to-date and comprehensive account of thestructures and physical chemistry properties of nucleic acids,with special emphasis on biological function. With a targetedaudience of 1)molecular biologists, 2)physical biochemists, and3)physical chemists, the book has been carefully organized toreach three different audiences while requiring only introductoryphysical chemistry and molecular biology as prerequisites. NucleicAcidswill serve as a textbook in physical biochemistry andbiophysical chemistry classes, as well as a supplemental text incourses on nucleic acid biochemistry or molecular biology, and asa personal reference for students and researchers in thesefields. KeyFeatures Organized according to a systematic consideration of techniques used in the study of nucleic acid structure and properties. Key topics--such as protein-DNA and protein-drug complexes, conformational transitions, characterization of nucleic acids by gel and solution techniques, and behavior of supercoiled DNA--are covered in great detail as veritable mini-monographs. Heavily illustrated with diagrams, graphs, and molecular structures, including nearly 2 dozen color figures. Includes numerous figures, tables and an extensive bibliography to facilitate use as a reference volume.
Category: Science

Nucleic Acids

Author : Marcelo Larramendy
ISBN : 9789535122647
Genre : Science
File Size : 27.5 MB
Format : PDF, ePub, Docs
Download : 595
Read : 759

This edited book, "Nucleic Acids - From Basic Aspects to Laboratory Tools", contains a series of chapters that highlight the development and status of the various aspects of the nucleic acids related to DNA chemistry and biology and the molecular application of these small DNA molecules and related synthetic analogues within biological systems. Furthermore, it is hoped that the information in the present book will be of value to those directly engaged in the handling and use of nucleic acids, and that this book will continue to meet the expectations and needs of all who are interested in the different fascinating aspects of molecular biology.
Category: Science

Nucleic Acids And Molecular Biology

Author : Fritz Eckstein
ISBN : 9783642837098
Genre : Science
File Size : 32.60 MB
Format : PDF
Download : 366
Read : 815

A wide range of topics are covered, including articles on nucleic acid structure, through their interactions with proteins to the control of gene expression. A number of authors address the subject of RNA, including the difficult but important subject of its chemical synthesis, the complexities of its structures and the mechanisms of transcript splicing. The probing of DNA structure is reviewed in papers on the application of hydroxyl radical and 1,10 phenanthroline copper cleavages. A number of important DNA-protein interactions are discussed, including DNA polymerase, the tryptophan and deoR repressors, and the resolvase enzymes which cleave Holliday junctions in recombination. Gene transcription is also covered, from the points of view of DNA methylation, mammalian ribosomal and avian lysozyme genes, and the control of transcription in the proto-oncogene c-fos. Finally, the plant kingdom has not been forgotten with articles on development and transposition in plants.
Category: Science

Peptide Nucleic Acids

Author : Peter E. Nielsen
ISBN : 0954523245
Genre : Science
File Size : 40.45 MB
Format : PDF, Docs
Download : 507
Read : 1229

Peptide Nucleic Acids, Second Edition has been extensively revised, updated, and enlarged to contain many new chapters covering the most recent topics and applications in this fast-moving field. The book contains state-of-the-art protocols and applications on all aspects of peptide nucleic acids. Concepts are clearly explained with each chapter containing concise background information. Written by leading experts in the field, the book is an invaluable and complete reference work on this novel and exciting area.
Category: Science

Mass Spectrometry Of Nucleosides And Nucleic Acids

Author : Joseph H. Banoub
ISBN : 1420044036
Genre : Science
File Size : 22.69 MB
Format : PDF, ePub
Download : 688
Read : 1181

Assembling the work of an international panel of researchers, Mass Spectrometry of Nucleosides and Nucleic Acids summarizes and reviews the latest developments in the field and provides a window on the next generation of analysis. Beginning with an overview of recent developments, the book highlights the most popular ionization methods and illustrates the diversity of strategies employed in the characterization and sequencing of DNA and RNA oligomers, nucleosides, nucleotides, and adducts. It describes studies performed on deoxyinosine and its analogues and provides an introduction to tandem mass spectrometry (MS/MS). Next, the contributors examine mass spectrometric application in the study of cyclic nucleotides in biochemical signal transduction. They analyze urinary modified nucleosides and explore DNA adducts. They discuss isotope labeling of DNA-mass spectrometry (ILD-MS) and examine various uses of electrospray ionization mass spectrometry (ESI-MS). The book reviews recent progress in the direct MS characterization of noncovalent nucleic acid-protein complexes, explores the interaction and ionization of guanidine-derived compounds with highly acidic biomolecules, and examines quantitative identification of nucleic acids via signature digestion products detected using mass spectrometry. The book describes a direct-infusion ESI-MS approach that can serve as a screening technique for the presence of modified nucleosides from small RNAs. Lastly, it discusses the LC-MS/MS method for the in vitro replication studies on damage-containing DNA substrates, and concludes with an examination of the influence of metal ions on the structure and reactivity of nucleic acids. The exciting developments in mass spectrometry technology have fueled incredible advances in our understanding of nucleic acids and their complexes. The contributions presented in this volume capture the range of these advances, helping to inspire new findings and avenues of research.
Category: Science

Nucleic Acids Nucleotides And Nucleosides Advances In Research And Application 2013 Edition

Author :
ISBN : 9781481690461
Genre : Science
File Size : 20.31 MB
Format : PDF, ePub, Mobi
Download : 478
Read : 415

Nucleic Acids, Nucleotides, and Nucleosides—Advances in Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Nucleic Acids, Nucleotides, and Nucleosides—Advances in Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Nucleic Acids, Nucleotides, and Nucleosides—Advances in Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Category: Science

The Biochemistry Of The Nucleic Acids

Author : R.L.P. Adams
ISBN : 9789401122900
Genre : Science
File Size : 46.51 MB
Format : PDF, Docs
Download : 600
Read : 720

When the first edition of this book was published in 1950, it predated the publication of the double-helical structure of DNA by three years. It is not, therefore, surprizing that nothing of the original book remains in the current edition. Indeed, such is the pace of change in the field of nucleic acids that less than 50% of material incorporated into the 1986 edition has been retained. The book aims at the advanced undergraduate and at graduates that are undertaking course work or requiring an in-depth background for their research. It also aims to provide the established scientist with a single text that permits updating across the whole field from DNA structure, replication and repair, through gene expression and its control to protein synthesis. Every chapter is accompanied by thorough referencing that enables the reader to evaluate personally the data and methodology that cannot be included in the text. In an attempt to keep this list within bounds, references are limited to about ten per page and, to accommodate the more recent literature, many of the older references have been left out in this latest edition.
Category: Science

Dynamics Of Proteins And Nucleic Acids

Author : J. Andrew McCammon
ISBN : 0521356520
Genre : Science
File Size : 62.94 MB
Format : PDF, ePub, Docs
Download : 270
Read : 178

This book is a self-contained introduction to the theory of atomic motion in proteins and nucleic acids. An understanding of such motion is essential because it plays a crucially important role in biological activity. The authors, both of whom are well known for their work in this field, describe in detail the major theoretical methods that are likely to be useful in the computer-aided design of drugs, enzymes and other molecules. A variety of theoretical and experimental studies is described and these are critically analyzed to provide a comprehensive picture of dynamic aspects of biomolecular structure and function. The book will be of interest to graduate students and research workers in structural biochemistry (X-ray diffraction and NMR), theoretical chemistry (liquids and polymers), biophysics, enzymology, molecular biology, pharmaceutical chemistry, genetic engineering and biotechnology.
Category: Science

Chemical Biology Of Nucleic Acids

Author : Volker A. Erdmann
ISBN : 9783642544521
Genre : Science
File Size : 25.19 MB
Format : PDF, ePub, Docs
Download : 373
Read : 1019

This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.
Category: Science

Proteins And Nucleic Acids

Author : Isidore Gersh
ISBN : 9780323151504
Genre : Science
File Size : 20.16 MB
Format : PDF, ePub
Download : 588
Read : 979

Submicroscopic Cytochemistry, Volume I: Proteins and Nucleic Acids presents laboratory findings and theoretical aspects involved or derived from submicroscopic cytochemistry study of proteins and nucleic acids. It is a two-volume book, encompassing 14 chapters covering three major topics: the pattern of distribution of nucleic acids at the molecular level in various cells and states of activity and in relation to protein synthesis; the molecular and macromolecular organization of cellular membranes; and the origin and distribution of the major macromolecular aggregates of connective tissue. After a brief introduction to the aspects of submicroscopic cytochemistry, the book discusses morphology, with emphasis on the distribution of cell components and their organization in cells at the macromolecular level. It then presents developed methods to preserve and selectively identify proteins, nucleic acids, lipids, acid mucopolysaccharides, and molecular aggregates very nearly in the position they occupied in the living state. Chapters 8 to 12 describe DNA molecular patterns during cell differentiation and cell maturation, and the alteration of these patterns in certain mouse cells. A discussion on DNA molecular patterns during metaplasia of stratified squamous mouse epithelium and of spinal ganglion cells during regeneration is provided. The concluding chapters examine DNA organization during mitotic cycle in Drosophila eggs and the persistence of chromosome individuality during interphase. This book is a valuable source of information for cytochemists, cell biologists, cell researchers, and protein nucleic acid enthusiasts who wish to expand their knowledge on comprehensive cytochemistry laboratory study.
Category: Science

Peptide Nucleic Acids Morpholinos And Related Antisense Biomolecules

Author : Christopher Janson
ISBN : 9780387329567
Genre : Medical
File Size : 28.34 MB
Format : PDF, ePub
Download : 984
Read : 806

This volume is unique to the existing literature in the Peptide Nucleic Acid field, in that it focuses on comparing and contrasting PNA with other available oligonucleotide homologues and considers areas in which these biomolecules could be profitably applied to clinical and diagnostic applications. Part I of the book addresses comparative strengths and weaknesses of various nucleoside homologues. Part II of the book addresses specific translational or clinical applications for PNA and related antisense biomolecules. The editors have succeeded in presenting a balanced yet broad view of the methods available for gene targeting and modification.
Category: Medical

Nucleic Acids And Proteins In Soil

Author : Paolo Nannipieri
ISBN : 9783540294498
Genre : Science
File Size : 30.93 MB
Format : PDF, ePub, Docs
Download : 658
Read : 928

With millions of different bacterial species living in soil, the microbial community is extremely complex, varying at very small scales. Microbe-driven functions are essential for most processes in soil. Thus, a better understanding of this microbial diversity will be invaluable for the management of the various soil functions. Nucleic Acids and Proteins in Soil combines traditional approaches in soil microbiology and biochemistry with the latest techniques in molecular microbial ecology. Included are methods to analyse the presence and importance of nucleic acids and proteins both inside and outside microbial cells, the horizontal gene transfer which drives bacterial diversity, as well as soil proteomes. Further chapters describe techniques such as PCR, fingerprinting, the challenging use of gene arrays for structural and functional analysis, stable isotope probing to identify in situ metabolic functions, and the use of marker and reporter genes in soil microbial ecology.
Category: Science

Nucleic Acids

Author : Lawrence Grossman
ISBN : UCSD:31822015245079
Genre : Acidos nucleicos
File Size : 51.2 MB
Format : PDF
Download : 139
Read : 1098

The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences.
Category: Acidos nucleicos

The Chemical Biology Of Nucleic Acids

Author : Günter Mayer
ISBN : 9781119957263
Genre : Science
File Size : 81.94 MB
Format : PDF, Mobi
Download : 165
Read : 600

With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.
Category: Science

Nucleic Acids

Author : Shawn Doonan
ISBN : 0854044817
Genre : Nucleic acids
File Size : 46.52 MB
Format : PDF
Download : 205
Read : 452

Although targeted specifically at undergraduate chemistry students, Nucleic Acids will also be of interest to undergraduates studying biochemistry.
Category: Nucleic acids

Antisense Nucleic Acids And Proteins

Author : Joseph N. M. Mol
ISBN : 0824785169
Genre : Science
File Size : 20.28 MB
Format : PDF, ePub, Docs
Download : 380
Read : 469

A compilation of papers from many different scientific meetings in recent years, this reference source reviews the use of antisense nucleic acids to modulate or down-regulate gene expression, provides clues on the action mechanism of sense and antisense genes as well as data on antisense nucleic aci
Category: Science

Circulating Nucleic Acids In Plasma And Serum

Author : Peter B. Gahan
ISBN : 9048193826
Genre : Medical
File Size : 23.14 MB
Format : PDF, ePub, Mobi
Download : 693
Read : 209

DNA and RNA fractions have been isolated from the whole blood, serum, plasma, the surface of blood cells, urine, saliva and spinal fluid from both healthy individuals and clinical patients. Recent developments are presented concerning the isolation, quantification and analysis of these molecules and their use in the identification of specific nucleic acid fragments related to a variety of clinical disorders thereby permitting their early diagnosis and prognosis.
Category: Medical