Nanofibres In Drug Delivery

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Nanofibres In Drug Delivery

Author : Gareth R. Williams
ISBN : 9781787350236
Genre : Medical
File Size : 88.60 MB
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In recent years there has been an explosion of interest in the production of nanoscale fibres for drug delivery and tissue engineering. Nanofibres in Drug Delivery aims to outline to new researchers in the field the utility of nanofibres in drug delivery, and to explain to them how to prepare fibres in the laboratory. The book begins with a brief discussion of the main concepts in pharmaceutical science. The authors then introduce the key techniques that can be used for fibre production and explain briefly the theory behind them. They discuss the experimental implementation of fibre production, starting with the simplest possible set-up and then moving on to consider more complex arrangements. As they do so, they offer advice from their own experience of fibre production, and use examples from current literature to show how each particular type of fibre can be applied to drug delivery. They also consider how fibre production could be moved beyond the research laboratory into industry, discussing regulatory and scale-up aspects.
Category: Medical

Recent Development Of Electrospinning For Drug Delivery

Author : Romána Zelkó
ISBN : 9783039281404
Genre : Medical
File Size : 37.84 MB
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Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (i.e., high specific surface area, porosity, and the possibility of controlling the crystalline–amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is also responsible for their physical–chemical instability. This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery and wound healing applications, covering recent advantages and future directions in electrospun fiber formulations and scalability. Moreover, it serves to highlight and capture the contemporary progress in electrospinning techniques, with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. All aspects of small molecule or biologics-loaded fibrous dosage forms, focusing on the processability, structures and functions, and stability issues, are included.
Category: Medical

Synthesis And Characterization Of Electrospun Nanofibers For Advanced Drug Delivery And Cell Culturing

Author : Muhammet Ceylan
ISBN : OCLC:1101121964
Genre : Electronic dissertations
File Size : 76.2 MB
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This work is concerned with synthesis and characterization of electrospun nanofibers for advanced drug delivery and cell culturing. Poly--e-caprolactone (PCL), composed of different inclusions such as gentamicin, plasmid DNA, and gelatin, is used to fabricate nanofibers using electrospinned for drug delivery and cell culturing. The plasmid DNA enhanced green fluorescent protein (EGFP) with cyromegalovirus (CMV) promoter (PCMVb-GFP) was ampkufued with Escherichia coli (E. coli). The plasmid DNA enhanced green fluorescent protein (EGFP) with cytomegalovi.i1.1s (CMV) promoter (PCMVb-GFP) was amp lified with Esche;ichia coli (E. coli). PCL was chosen because it has been approved by the Food and Drug Administration (FDA) in implantable material applications used iii the human body, and it has biocompatible and biodegradable material. which plays a critical role in tissue engi.i1eering. wound heali.i1g, and drug delivery. The main reason for using electrospun nanofibers in this study is because it has high surface area. porosity, and penneability. Sca1ming electron microscopy (SEM) images show that the nanoscale fiber structures have a diameter ranging of 50 to 250 mn with some bead fonnations. The cytotoxicity study revealed that PCL nanofibers are not toxic, and cell viability was above 70%. An energy dispersive x-ray spectroscopy (EDS) was used iii order to confirm the ratio of the gelati.!1 component iii the fibers. To visually express the inclusio n of gentamicin iii the fibers a fourier transform infrared (FTIR) spectroscopy was used. Differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA) techniques were also applied on the prepared sample. Overall, this study showed that PCL is a good candidate for several biomedical applications and may open up new possibilities for partiicularly DNA, gene, nerve cell myelination and drug delivery purposes.
Category: Electronic dissertations

Wound Healing Tissue Repair And Regeneration In Diabetes

Author : Debasis Bagchi
ISBN : 9780128164136
Genre : Health & Fitness
File Size : 38.74 MB
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Wound Healing, Tissue Repair and Regeneration in Diabetes explores a wide range of topics related to wound healing, tissue repair and regeneration, putting a special focus on diabetes and obesity. The book addresses the molecular and cellular pathways involved in the process of wound repair and regeneration. Other sections explore a wide spectrum of nutritional supplements and novel therapeutic approaches, provide a comprehensive overview, present various types of clinical aspects related to diabetic wounds, including infection, neuropathy, and vasculopathy, provide an exhaustive review of various foods, minerals, supplements and phytochemicals that have been proven beneficial, and assess future directions. This book is sure to be a welcome resource for nutritionists, practitioners, surgeons, nurses, wound researchers and other health professionals.
Category: Health & Fitness

The Future Of Pharmaceutical Product Development And Research

Author :
ISBN : 9780128144558
Genre : Medical
File Size : 24.27 MB
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The Future of Pharmaceutical Product Development and Research examines the latest developments in the pharmaceutical sciences, also highlighting key developments, research and future opportunities. Written by experts in the field, this volume in the Advances in Pharmaceutical Product Development and Research series deepens our understanding of the product development phase of drug discovery and drug development. Each chapter covers fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and the pharmaceutical industry. The book focuses on excipients, radiopharmaceuticals, and how manufacturing should be conducted in an environment that follows Good Manufacturing Practice (GMP) guidelines. Researchers and students will find this book to be a comprehensive resource for those working in, and studying, pharmaceuticals, cosmetics, biotechnology, foods and related industries. Provides an overview of practical information for clinical trials Outlines how to ensure an environment that follows Good Manufacturing Practice (GMP) Examines recent developments and suggests future directions for drug production methods and techniques
Category: Medical

Nanostructures For Drug Delivery

Author : Ecaterina Andronescu
ISBN : 9780323461498
Genre : Medical
File Size : 63.86 MB
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Nanostructures for Drug Delivery extensively covers the various nanostructured products that have been tested as carriers in target drug delivery systems. In addition, the book analyses the advantages of, and issues related to, using nanostructured materials in drug delivery systems, also detailing various nanocarrier preparation techniques. As delivering the drug to the target site is a major problem in providing effective treatment for many diseases, this book covers the latest advancements in numerous nanotechnological products that are being used in disease detection, controlled drug delivery, as biosensors, and in tissue engineering that have been developed for more efficient patient healthcare. Due to the versatility of nanostructured materials, it is now possible to deliver a drug at its target site in a more accurate and efficient way. This volume is an up-to-date, state-of-the-art work that highlights the principal mechanistic aspects related to the delivery of active nanoscale therapeutic agents (natural or synthetic) and their release profile in different environmental media. It highlights nanoscale encapsulation strategies and discusses both organic and inorganic nanomaterials as carriers and delivery platforms. Demonstrates how nanostructures are successfully employed in drug delivery stems and as drug delivery agents, allowing biomaterials scientists and biochemists to create more effective drug delivery systems Offers an overview of recent research into the use of nanostructures in drug delivery techniques in a cogent, synthesized way, allowing readers to quickly familiarize themselves with this area Includes examples of how the application of nanostructures have improved the efficiency of drug delivery systems, showing medical scientists how they are beneficial
Category: Medical

Nanoparticulate Drug Delivery Systems

Author : Deepak Thassu
ISBN : 1420008447
Genre : Medical
File Size : 64.38 MB
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With the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. Nanoparticulate Drug Delivery Systems addresses the scientific methodologies, formulation, processing, applications, recent trends, and e
Category: Medical

Nanomedicine For Ischemic Cardiomyopathy

Author : Morteza Mahmoudi
ISBN : 9780128174340
Genre : Science
File Size : 80.79 MB
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Nanomedicine for Ischemic Cardiomyopathy: Progress, Opportunities, and Challenges provides an overview on the recent advances in diagnostic and treatment of ischemic cardiomyopathy diseases including myocardial infarction. Shortcomings of the current methods and how nanomedicine can address those obstacles in the field are discussed including the limitations of newly developed cell therapy approaches to clinical translation and how nanomedicine may overcome crucial issues and facilitate the successful and efficient clinical translation of cell therapy. Biomolecular therapy is also explored as another powerful approach for regeneration of heart tissue including available methods and systematic delivery of biomolecules using nanocarriers to the injured part of myocardium through active targeting. Finally, coverage of major tissue engineering advances for myocardial regeneration, including use of epicardial nanostructured patches for regeneration of injured epicardium and the highly conductive patches for enhancing cross talks between the cardiomyocytes, is explored. This concise, yet rigorous coverage, of the field of cardiac nanotechnology outlines the innovative and necessary role of nanomedicine in regenerative medicine for cardiac repair allowing researchers, clinicians, and nanotechnologists to examine the strengths and limitations of current findings and predict future trends to advance the applications of nanotechnology in cardiovascular biomedical research.
Category: Science

Organic Materials As Smart Nanocarriers For Drug Delivery

Author : Alexandru Mihai Grumezescu
ISBN : 9780128136645
Genre : Science
File Size : 22.67 MB
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Organic Materials as Smart Nanocarriers for Drug Delivery presents the latest developments in the area of organic frameworks used in pharmaceutical nanotechnology. An up-to-date overview of organic smart nanocarriers is explored, along with the different types of nanocarriers, including polymeric micelles, cyclodextrins, hydrogels, lipid nanoparticles and nanoemlusions. Written by a diverse range of international academics, this book is a valuable reference for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of organic smart nanocarriers. Explores the most recent molecular- and structure-based applications of organic smart nanocarriers in drug delivery Highlights different smart nanocarriers and assesses their intricate organic structural properties for improving drug delivery Assesses how molecular organic frameworks lead to more effective drug delivery systems
Category: Science

Nanotechnology In Drug Delivery

Author : Melgardt M. de Villiers
ISBN : 0387776680
Genre : Medical
File Size : 74.77 MB
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The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.
Category: Medical

Fundamentals And Applications Of Micro And Nanofibers

Author : Alexander L. Yarin
ISBN : 9781107060296
Genre : Science
File Size : 69.78 MB
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A comprehensive exposition of micro and nanofiber formation processes, from physical foundations to production and applications.
Category: Science

Nanofibers And Nanotechnology In Textiles

Author : P. Brown
ISBN : 1845691059
Genre : Technology & Engineering
File Size : 44.93 MB
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Nanotechnology is revolutionising the world of materials. This important book reviews its impact in developing a new generation of textile fibers with enhanced functionality and a wide range of applications. The first part of the book reviews nanofiber production, discussing how different fiber types can be produced using electrospinning techniques. Part two analyses the production and properties of carbon nanotubes and polymer nanocomposites and their applications in such areas as aerospace engineering. The third part of the book considers ways of using nanotechnology to improve polymer properties such as thermal stability and dyeability. The final part of the book reviews the use of nanotechnology to modify textile surfaces, including the use of coatings and films, in order to improve hydrophobic, filtration and other properties. Nanofibers and nanotechnology in textiles is a valuable reference in assessing and using a new generation of textile fibers in applications as diverse as tissue and aerospace engineering. Nanotechnology is revolutionising the world of materials Learn about a new generation of textile fibers that have a wide range of applications Examines how to improve polymer properties
Category: Technology & Engineering

An Introduction To Electrospinning And Nanofibers

Author : Seeram Ramakrishna
ISBN : 9789812564153
Genre : Science
File Size : 85.31 MB
Format : PDF
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The research and development of nanofibers has gained much prominence in recent years due to the heightened awareness of its potential applications in the medical, engineering and defense fields. Among the most successful methods for producing nanofibers is the electrospinning process. In this timely book, the areas of electrospinning and nanofibers are covered for the first time in a single volume. The book can be broadly divided into two parts: the first comprises descriptions of the electrospinning process and modeling to obtain nanofibers while the second describes the characteristics and applications of nanofibers. The material is aimed at both newcomers and experienced researchers in the area.
Category: Science