IONIC CHANNELS OF EXCITABLE MEMBRANES

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Ionic Channels Of Excitable Membranes

Author : Bertil Hille
ISBN : UOM:39015024124383
Genre : Science
File Size : 69.44 MB
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This new, fully revised and expanded edition of Ionic Channels of Excitable Membranes includes new chapters on fast chemical synapses, modulation through G protein coupled receptors and second messenger systems, molecules cloning, site directed mutagenesis, and cell biology. It begins with the classical biophysical work of Hodgkin and Huxley and then weaves a description of the known ionic channels together with their biological functions. The book continues by developing the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ionic Channels of Excitable Membranes is written to be accessible and interesting to biological and physical scientists of all kinds.
Category: Science

Ion Channels Of Excitable Membranes

Author : Bertil Hille
ISBN : 0878933212
Genre : Science
File Size : 27.34 MB
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This fully revised and expanded third edition describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation.
Category: Science

Fundamental Concepts In Biophysics

Author : Thomas Jue
ISBN : 9781597453974
Genre : Science
File Size : 38.31 MB
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In the first volume, Fundamental Concepts in Biophysics, the authors lay down a foundation for biophysics study. Rajiv Singh opens the book by pointing to the central importance of “Mathematical Methods in Biophysics”. William Fink follows with a discussion on “Quantum Mechanics Basic to Biophysical Methods”. Together, these two chapters establish some of the principles of mathematical physics underlying many biophysics techniques. Because computer modeling forms an intricate part of biophysics research, Subhadip Raychaudhuri and colleagues introduce the use of computer modeling in “Computational Modeling of Receptor–Ligand Binding and Cellular Signaling Processes”. Yin Yeh and coworkers bring to the reader’s attention the physical basis underlying the common use of fluorescence spectroscopy in biomedical research in their chapter “Fluorescence Spectroscopy”. Electrophysiologists have also applied biophysics techniques in the study of membrane proteins, and Tsung-Yu Chen et al. explore stochastic processes of ion transport in their “Electrophysiological Measurements of Membrane Proteins”. Michael Saxton takes up a key biophysics question about particle distribution and behavior in systems with spatial or temporal inhomogeneity in his chapter “Single–Particle Tracking”. Finally, in “NMR Measurement of Biomolecule Diffusion”, Thomas Jue explains how magnetic resonance techniques can map biomolecule diffusion in the cell to a theory of respiratory control. This book thus launches the Handbook of Modern Biophysics series and sets up for the reader some of the fundamental concepts underpinning the biophysics issues to be presented in future volumes.
Category: Science

Ion Channels

Author : Bernardo Rudy
ISBN : 012601695X
Genre : Science
File Size : 32.69 MB
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This is an unabridged, comb bound version of Ion Channels: Volume 207 of Methods of Enzymology. Techniques for the electrophysiological recording of ion channels in a number of different cell types, including microorganisms, are described in this volume. Key Features * Applications of electrophysiological techniques * Expression in heterologous systems * Reconstitution of lipid bilayers * Purification and characterization of ion channel proteins and genes * Recording of ion channels of intracellular membranes and microorganisms * Data storage and analysis
Category: Science

Ion Channels Of Excitable Cells

Author : Toshio Narahashi
ISBN : 9781483288338
Genre : Medical
File Size : 70.14 MB
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Because of the highly significant and widely recognized roles of ion channels in physiology, pathophysiology, pharmacology, and toxicology, the term ion channel has now become a household word in the biomedical sciences. This volume covers preparations and techniques for the study of various ion channels. Both voltage-gated and ligand-gated ion channels of neurons, axons, and cardiac and smooth muscles are covered. It includes not only patch clamp techniques but molecular biology and imaging techniques as well. Comprehensive protocols included for the study of: Ion channels using patch-clamp, molecular biology, and imaging techniques Role of ion channels in physiology, pathophysiology, pharmacology, and toxicology Specific ion channels of specific tissues
Category: Medical

Physiology Of Excitable Membranes

Author : J. Salánki
ISBN : 9781483146928
Genre : Science
File Size : 66.7 MB
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Physiology of Excitable Membranes contains plenary lecture and most of the papers presented at five symposia of the Section ""General Cell Physiology"" at the 28th International Congress of Physiological Sciences. Organized into 44 chapters, this book begins with a discussion on the ionic mechanisms of excitability of nerve cells. Subsequent chapters focus on charge movement in nerve membrane; calcium electrogenesis; optical changes during electrogenesis; synaptic transmission and modulation; and transmission in autonomic ganglia.
Category: Science

Ion Adventure In The Heartland

Author : Dale Dubin
ISBN : 9780912912110
Genre : Science
File Size : 58.75 MB
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A "consilience" or confluence of ionic-molecular knowledge from many research disciplines correlated into a grand-unifying, functional model of cardiac physiology modulated by the autonomic nervous system.
Category: Science

Cellular Physiology And Neurophysiology E Book

Author : Mordecai P. Blaustein
ISBN : 9780323086646
Genre : Medical
File Size : 44.73 MB
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Gain a quick and easy understanding of this complex subject with the 2nd edition of Cellular Physiology and Neurophysiology by doctors Mordecai P. Blaustein, Joseph PY Kao, and Donald R. Matteson. The expanded and thoroughly updated content in this Mosby Physiology Monograph Series title bridges the gap between basic biochemistry, molecular and cell biology, neuroscience, and organ and systems physiology, providing the rich, clinically oriented coverage you need to master the latest concepts in neuroscience. See how cells function in health and disease with extensive discussion of cell membranes, action potentials, membrane proteins/transporters, osmosis, and more. Intuitive and user-friendly, this title is a highly effective way to learn cellular physiology and neurophysiology. Focus on the clinical implications of the material with frequent examples from systems physiology, pharmacology, and pathophysiology. Gain a solid grasp of transport processes—which are integral to all physiological processes, yet are neglected in many other cell biology texts. Understand therapeutic interventions and get an updated grasp of the field with information on recently discovered molecular mechanisms. Conveniently explore mathematical derivations with special boxes throughout the text. Test your knowledge of the material with an appendix of multiple-choice review questions, complete with correct answers Understand the latest concepts in neurophysiology with a completely new section on Synaptic Physiology. Learn all of the newest cellular physiology knowledge with sweeping updates throughout. Reference key abbreviations, symbols, and numerical constants at a glance with new appendices.
Category: Medical

Ion Channels And Their Inhibitors

Author : Satya Prakash Gupta
ISBN : 3642199224
Genre : Science
File Size : 48.47 MB
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Being the crucial components of living cells, ion channels are important targets of therapeutic agents. Historically, it has been challenging to develop drugs on this target class. A major issue with target based ion channel drug development is the identification of effective small chemical leads for medicinal chemistry optimization to the clinical candidate status. Thus enough attention has been paid to the study of structure and functions of ion channels and their potential inhibitors. The present book compiles important chapters authored by eminent workers in the field to cover important recent advances in the studies of the structure and functions of ion channels and their inhibitors, such as sodium ion, potassium ion, chloride ion, calcium ion channel inhibitors. The book may be of great use to the students and scientists working in the area of molecular biology, biochemistry, physiology, neurobiology, and medicinal chemistry.
Category: Science