Fundamentals Of Genetic Epidemiology

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Fundamentals Of Genetic Epidemiology

Author : Muin J. Khoury
ISBN : 9780195052886
Genre : Medical
File Size : 41.72 MB
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With continued progress in mapping and sequencing of the human genome, and increasing recognition of the role of genes in disease etiology, there is a need for a more sophisticated approach to the investigation of the causes of complex chronic diseases. This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease etiology. After a brief historical overview of genetics and epidemiology and their gradual rapprochement, the authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations. They describe fundamental research strategies of genetic epidemiology including population and family studies. Among the former are the study of the distribution of genetic traits and the role of nonspecific genetic indicators (such as inbreeding and admixture) in the occurrence of diseases. Among the latter are the analysis of familial aggregation of disease and its causes by epidemiologic methods as well as techniques of formal genetic analysis (variance components, segregation and linkage analysis). Finally, the authors discuss the increasing applications of genetic epidemiology in preventive medicine, public health surveillance, and the emerging ethical issues regarding use of genetic information in society.
Category: Medical

Encyclopedia Of Epidemiology

Author : Sarah Boslaugh
ISBN : 9781412928168
Genre : Medical
File Size : 66.68 MB
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The Encyclopedia of Epidemiology presents state-of-the-art information from the field of epidemiology in a less technical and accessible style and format. With more than 600 entries, no single reference provides as comprehensive a resource in as focused and appropriate manner. The entries cover every major facet of epidemiology, from risk ratios to case-control studies to mediating and moderating variables, and much more. Relevant topics from related fields such as biostatistics and health economics are also included.
Category: Medical

Genetic Epidemiology

Author : Melissa A. Austin
ISBN : 9781780641812
Genre : Medical
File Size : 28.75 MB
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Genetic epidemiology plays a key role in discovering genetic factors influencing health and disease, and in understanding how genes and environmental risk factors interact. There is growing interest in this field within public health, with the goal of translating the results into promoting health and preventing disease in both families and populations. This textbook provides graduate students with a working knowledge of genetic epidemiology research methods. Following an overview of the field, the book reviews key genetic concepts, provides an update on relevant genomic technology, including genome-wide chips and DNA sequencing, and describes methods for assessing the magnitude of genetic influences on diseases and risk factors. The book focuses on research study designs for discovering disease susceptibility genes, including family-based linkage analysis, candidate gene and genome-side association studies, assessing gene-environment interactions and epistasis, studies of Non-Mendelian inheritance, and statistical analyses of data from these studies. Specific applications of each research method are illustrated using a variety of diseases and risk factors relevant to public health, and useful web-based genetic analysis software, human reference panels, and repositories, that can greatly facilitate this work, are described.
Category: Medical

Statistical Methods In Genetic Epidemiology

Author : Duncan C. Thomas
ISBN : 9780195159394
Genre : Medical
File Size : 86.85 MB
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This balanced and well-integrated text gives a lucid overview of the entire process of genetic epidemiology, from familial aggregation through segregation, likage, and association studies. It is illustrated throughout with examples from the literature on cancer genetics. Statistical concepts are developed in depth, but with a focus on applications. Introductory chapters on molecular biology, Mendelian genetics, epidemiology, statistics, and population genetics are included. Oriented to graduate students in biostatistics, epidemiology, and human genetics, the book will also be a useful reference for researchers. It gives equal emphasis to study designs and data analysis.
Category: Medical

Genetics Health Care And Public Policy

Author : Alison Stewart
ISBN : 9781139463294
Genre : Medical
File Size : 89.72 MB
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Genetics, Health Care and Public Policy is an introduction to the new discipline of public health genetics. It brings together the insights of genetic and molecular science as a means of protecting and improving the health of the population. Its scope is wide and requires an understanding of genetics, epidemiology, public health and the principles of ethics, law and the social sciences. This book sets out the basic principles of public health genetics for a wide audience from those providing health care to those involved in establishing policy. The emphasis throughout the text is on providing an accessible introduction to the field. The content moves from the basic concepts, including definitions and history, through chapters on genetics, genetic technology, epidemiology, genetics in medicine, genetics in health services, ethical, legal and social implications, to the implications for health policy. It provides one-stop, introductory coverage of this rapidly developing and multidisciplinary field.
Category: Medical

Textbook Of Psychiatric Epidemiology

Author : Ming T. Tsuang
ISBN : 9780470977408
Genre : Medical
File Size : 70.60 MB
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The new edition of this critically praised textbook continues to provide the most comprehensive overview of the concepts, methods, and research advances in the field; particularly the application of molecular genomics and of neuroimaging. It has been revised and enhanced to capitalize on the strengths of the first and second editions while keeping it up-to-date with the field of psychiatry and epidemiology. This comprehensive publication now includes chapters on experimental epidemiology, gene-environment interactions, the use of case registries, eating disorders, suicide, childhood disorders and immigrant populations, and the epidemiology of a number of childhood disorders. As in the first and second editions, the objective is to provide a comprehensive, easy to understand overview of research methods for the non-specialist. The book is ideal for students of psychiatric epidemiology, psychiatric residents, general psychiatrists, and other mental health professionals. The book features a new editor, Peter Jones, from the University of Cambridge, who joins the successful US team of Ming Tsuang and Mauricio Tohen.
Category: Medical

Human Genome Epidemiology

Author : Muin J. Khoury
ISBN : 9780195146745
Genre : Medical
File Size : 72.50 MB
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Advances in genomics are expected to play a central role in medicine and public health in the future by providing a genetic basis for disease prediction and prevention. The transplantation of human gene discoveries into meaningful actions to improve health and prevent disease depends on scientific information from multiple disciplines, including epidemiology. This book describes the important role that epidemiologic methods play in the continuum from gene discovery to the development and application of genetic tests. It proceeds systematically from the fundamentals of genome technology and gene discovery, to epidemiologic approaches to gene characterization in the population, to the evaluation of genetic tests and their use in health services. These methodologic approaches are then illustrated with several disease-specific case studies. The book provides a scientific foundation that will help researchers, policy makers, and practitioners integrate genomics into medical and public health practice.
Category: Medical

Epidemiology For Public Health Practice

Author : Robert H. Friis
ISBN : 0763731706
Genre : Medical
File Size : 87.83 MB
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Now in its third edition, Epidemiology for Public Health Practice provides a comprehensive look at all major topics, from study designs and descriptive epidemiology to quantitative measures and termin
Category: Medical

Genomics And Health In The Developing World

Author : Dhavendra Kumar
ISBN : 9780195374759
Genre : Medical
File Size : 80.33 MB
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This book is designed to be the first major text to discuss advances in medical genetics in the developing world.
Category: Medical

Investigating Neurological Disease

Author : Albert Hofman
ISBN : 0521000092
Genre : Medical
File Size : 86.24 MB
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This invaluable handbook for clinicians reviews the epidemiology, treatment and prognosis of all major diseases of the nervous system.
Category: Medical

Emery S Elements Of Medical Genetics E Book

Author : Peter D Turnpenny
ISBN : 9780702045059
Genre : Science
File Size : 38.22 MB
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Master the genetics you need to know with the updated 14th Edition of Emery’s Elements of Medical Genetics by Drs. Peter Turnpenny and Sian Ellard. Review the field’s latest and most important topics with user-friendly coverage designed to help you better understand and apply the basic principles of genetics to clinical situations. Learning is easy with the aid of clear, full-color illustrative diagrams, a wealth of clinical photographs of genetic diseases, multiple-choice and case-based review questions, and end-of-chapter summaries. With this highly visual, award-winning classic in your hands, you have all the genetics knowledge you need for exams or practice. This title includes additional digital media when purchased in print format. For this digital book edition, media content is not included. Get a broad view of medical genetics with a unique three-part structure that looks at the Principles of Human Genetics, Genetics in Medicine, and Clinical Genetics. Visualize the appearance of genetic disorders with a fantastic art program that presents many clinical photos of genetic diseases, and work through complicated ideas with an array of full-color illustrative diagrams. Master the material you need to know with a title preferred by faculty and students alike over the last three decades and awarded the British Medical Association Medial Student Textbook of the Year in 2008. Access to www.studentconsult.com, including 150 USMLE-style multiple choice questions to aid study and self-testing. Apply the latest research with chapters on developmental genetics, cancer genetics, prenatal testing and reproduction genetics, ‘clonal’ sequencing, and more. Understand complex concepts with the help of an increased number of diagrams. Be fully aware of social, ethical, and counseling issues by reviewing an improved section on these topics.
Category: Science

Toward A Genetics Of Language

Author : Mabel L. Rice
ISBN : 9781134789252
Genre : Language Arts & Disciplines
File Size : 42.25 MB
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The past decade has brought important new advances in the fields of genetics, behavioral genetics, linguistics, language acquisition, studies of language impairment, and brain imaging. Although these advances are each highly relevant to the determination of what a child is innately prepared to bring to language acquisition, the contributing fields of endeavor have traditionally been relatively self-contained, with little cross communication. This volume was developed with the belief that there is considerable value to be gained in the creation of a shared platform for a dialogue across the disciplines. Leading experts in genetics, linguistics, language acquisition, language impairment, and brain imaging are brought together for the purpose of exploring the current evidence, theoretical issues, and research challenges in a way that bridges disciplinary boundaries and points toward future developments in the search for the genetic and environmental bases of language acquisition and impairments. This collection provides discussions and summaries of: *breakthrough findings of the genetic underpinnings of dyslexia; *theoretical and empirical developments in the specification of a phenotype of language acquisition and impairment; *evidence of familiarity and twin concordances of specific language impairment; and *new evidence from brain imaging. It concludes with a critical response from an advocate of rational empiricism.
Category: Language Arts & Disciplines

The Adult Hip

Author : John J. Callaghan
ISBN : 0397517041
Genre : Medical
File Size : 61.29 MB
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This major two-volume reference provides comprehensive coverage of the evaluation and surgical management of problems of the hip. It begins with a thorough review of clinically relevant basic science, including the anatomy and biomechanics of the hip, the biomaterials used in hip reconstruction, the sequelae of wear, and the biology of bone autografts and allografts. A section on clinical science covers the clinical and radiological evaluation of the hip, the pathology of the hip, osteonecrosis of the hip and related disorders, perioperative considerations, surgical anatomy, and surgical approaches to the hip. Subsequent sections provide complete information on all current surgical procedures, including arthroscopy, resection arthroplasty, arthrodesis, osteotomy, total hip arthroplasty, complex total hip arthroplasty, procedures for the treatment of sepsis, and revision total hip arthroplasty. Complementing the text are more than 1,300 full-color and black-and-white illustrations, including drawings by a noted medical illustrator. Compatibility: BlackBerry® OS 4.1 or Higher / iPhone/iPod Touch 2.0 or Higher /Palm OS 3.5 or higher / Palm Pre Classic / Symbian S60, 3rd edition (Nokia) / Windows Mobile™ Pocket PC (all versions) / Windows Mobile Smartphone / Windows 98SE/2000/ME/XP/Vista/Tablet PC
Category: Medical

The Fundamentals Of Modern Statistical Genetics

Author : Nan M. Laird
ISBN : 1441973389
Genre : Medical
File Size : 25.56 MB
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This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.
Category: Medical

Biostatistical Genetics And Genetic Epidemiology

Author : Robert C. Elston
ISBN : UOM:39015054401784
Genre : Mathematics
File Size : 87.6 MB
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This is the third in a series of books based on articles from the Encyclopedia of Biostatistics. The editors have updated the articles from the Human Genetics section of the EoB, have adpated other articles to give them a genetic feel, and have included a number of newly commissioned articles.
Category: Mathematics

Vogel And Motulsky S Human Genetics

Author : Friedrich Vogel
ISBN : 3540602909
Genre : Science
File Size : 29.49 MB
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Provides information on the molecular basis of human genetics and outlines the principles of other epigenetic processes which together create the phenotype of a human being. This work also discusses the molecular basis for the concepts, methods and results in fields such as population genetics.
Category: Science