Environmental Epigenomics In Health And Disease

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Environmental Epigenomics In Health And Disease

Author : Randy L Jirtle
ISBN : 9783642233807
Genre : Medical
File Size : 68.22 MB
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There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without a change in the sequence of the DNA. The main components of the epigenetic code are DNA methylation, histone modifications, and non-coding RNAs. The epigenetic programs are established as stem cell differentiate during embryogenesis, and they are normally faithfully reproduced during mitosis. Moreover, they can also be maintained during meiosis, resulting in epigenetic transgenerational disease inheritance, and also potentially introducing phenotypic variation that is selected for in the evolution of new species. The objective of this book is to provide evidence that environmental exposures during early development can alter the risk of developing medical conditions, such as asthma, autism, cancer, cardiovascular disease, diabetes, obesity, and schizophrenia later in life by modifying the epigenome.
Category: Medical
Environmental Epigenomics in Health and Disease
Language: en
Pages: 302
Authors: Randy L Jirtle, Frederick L. Tyson
Categories: Medical
Type: BOOK - Published: 2013-05-16 - Publisher: Springer Science & Business Media

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without
Environmental Epigenetics in Toxicology and Public Health
Language: en
Pages: 364
Authors: Rebecca Fry
Categories: Medical
Type: BOOK - Published: 2020-10-23 - Publisher: Academic Press

Environmental Epigenetics in Toxicology and Public Health provides in-depth discussions of the suite of complex environmental factors shown to impact epigenetic components within the cell, as well as evidence that these epigenetic modifications are tied to early and later life health effects. This book offers a translational research perspective, highlighting
Environmental Epigenomics in Health and Disease
Language: en
Pages: 339
Authors: Randy L. Jirtle, Frederick L. Tyson
Categories: Medical
Type: BOOK - Published: 2013-05-13 - Publisher: Springer Science & Business Media

There are now compelling human epidemiological and animal experimental data that indicate the risk of developing adult-onset complex diseases and neurological disorders are influenced by persistent epigenetic adaptations in response to prenatal and early postnatal exposures to environmental factors. Epigenetics refers to heritable changes in gene function that occur without
Environmental Epigenomics in Health and Disease
Language: en
Pages: 356
Authors: Randy L. Jirtle, Frederick L. Tyson
Categories: Medical
Type: BOOK - Published: 2013-05-31 - Publisher:

Books about Environmental Epigenomics in Health and Disease
Epigenetics in Human Disease
Language: en
Pages: 577
Authors: Trygve O. Tollefsbol
Categories: Medical
Type: BOOK - Published: 2012 - Publisher: Academic Press

Epigenetics is one of the fastest growing fields of sciences, illuminating studies of human diseases by looking beyond genetic make-up and acknowledging that outside factors play a role in gene expression. The goal of this volume is to highlight those diseases or conditions for which we have advanced knowledge of