Drosophila Melanogaster

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Drosophila Melanogaster Practical Uses In Cell And Molecular Biology

Author :
ISBN : 0080859429
Genre : Science
File Size : 82.67 MB
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Drosophila melanogaster: Practical Uses in Cell and Molecular Biology is a compendium of mostly short technical chapters designed to provide state-of-the art methods to the broad community of cell biologists, and to put molecular and cell biological studies of flies into perspective. The book makes the baroque aspects of genetic nomenclature and procedure accessible to cell biologists. It also contains a wealth of technical information for beginning or advanced Drosophila workers. Chapters, written within a year of publication, make this topical volume a valuable laboratory guide today and an excellent general reference for the future. Key Features * Collection of ready-to-use, state-of-the art methods for modern cell biological and related research using Drosophila melanogaster * Accessible to both experienced Drosophila researchers and to others who wish to join in at the cutting edge of this system * Drosophila offers an easily managed life cycle, inexpensive lifestyle, extraordinarily manipulable molecular and classical genetics, now combined with powerful new cell biology techniques * Introduction and overview sections orient the user to the Drosophila literature and lore * Six full-color plates and over 100 figures and tables enhance the understanding of these cell biology techniques
Category: Science

Drosophila Melanogaster Drosophila Simulans So Similar So Different

Author : Pierre Capy
ISBN : 9789400709652
Genre : Science
File Size : 84.53 MB
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This book brings together most of the information available concerning two species that diverged 2-3 million years ago. The objective was to try to understand why two sibling species so similar in several characteristics can be so different in others. To this end, it was crucial to confront all data from their ecology and biogeography with their behavior and DNA polymorphism. Drosophila melanogaster and Drosophila simulans are among the two sibling species for which a large set of data is available. In this book, ecologists, physiologists, geneticists, behaviorists share their data on the two sibling species, and several scenarios of evolution are put forward to explain their similarities and divergences. This is the first collection of essays of its kind. It is not the final point of the analyses of these two species since several areas remain obscure. However, the recent publication of the complete genome of D. melanogaster opens new fields for research. This will probably help us explain why D. melanogaster and D. simulans are sibling species but false friends.
Category: Science

Brain Development In Drosophila Melanogaster

Author : Gerhard Martin Technau
ISBN : 0387782613
Genre : Medical
File Size : 68.61 MB
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The fruitfly Drosophila melanogaster is an ideal model system to study processes of the central nervous system This book provides an overview of some major facets of recent research on Drosophila brain development.
Category: Medical

Drosophila Melanogaster

Author : Farzana Khan Perveen
ISBN : 9789535138532
Genre : Technology & Engineering
File Size : 31.54 MB
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This book contains 12 chapters divided into two sections. Section 1 is "Drosophila - Model for Genetics." It covers introduction, chromosomal polymorphism, polytene chromosomes, chromosomal inversion, chromosomal evolution, cell cycle regulators in meiosis and nongenetic transgenerational inheritance in Drosophila. It also includes ecological genetics, wild-type strains, morphometric analysis, cytostatics, frequencies of early and late embryonic lethals (EEL and LEL) and mosaic imaginal discs of Drosophila for genetic analysis in biomedical research. Section 2 is "Drosophila - Model for Therapeutics." It explains Drosophila as model for human diseases, neurodegeneration, heart-kidney metabolic disorders, cancer, pathophysiology of Parkinson's disease, dopamine, neuroprotective therapeutics, mitochondrial dysfunction and translational research. It also covers Drosophila role in ubiquitin-carboxyl-terminal hydrolase-L1 (UCH-L1) protein, eye development, anti-dUCH antibody, neuropathy target esterase (NTE), organophosphorous compound-induced delayed neuropathy (OPIDN) and hereditary spastic paraplegia (HSP). It also includes substrate specificities, kinetic parameters of recombinant glutathione S-transferases E6 and E7 (DmGSTE6 and DmGSTE7), detoxification and insecticidal resistance and antiviral immunity in Drosophila.
Category: Technology & Engineering

The Genome Of Drosophila Melanogaster

Author : Dan L. Lindsley
ISBN : 9780323139847
Genre : Science
File Size : 89.11 MB
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Dedicated to the memory of George Lefevre in recognition of his exhaustive cytogenetic analysis of the X chromosome, The Genome of Drosophila melanogaster is the complete compendium of what is known about the genes and chromosomes of this widely used model organism. The volume is an up-to-date revision of Lindsley and Grell's 1968 work, Genetic Variations of Drosophila melanogaster. The new edition contains complete descriptions of normal and mutant genes including phenotypic, cytological, molecular, and bibliographic information. In addition, it describes thousands of recorded chromosome rearrangements used in research on Drosophila. This handbook and its accompanying polytene chromosome maps, are sturdily bound into the book as foldouts and available as a separate set, are essential research tools for the Drosophila community. Describes phenotype, cytology, and molecular biology of all recorded genes of Drosophila melanogaster, plus references to the literature Describes normal chromosome complement, special chromosome constructs, transposable elements, departures from diploidy, satellite sequences, and nonchromosomal inheritance Describes all recorded chromosome rearrangements of Drosophila melanogaster as of the end of 1989 Contains the cytogenetic map of all genes as of mid-1991 Contains the original polytene maps of C.B. Bridges, plus G. Lefevre's photographic equivalents, and the detailed maps of the chromosome arms produced by C.B. and P.M. Bridges All maps are reprinted as high-quality foldouts sturdily bound into the volume Maps may also be purchased separately in an eight-map packet, for laboratory and student use
Category: Science

Microscopic Analysis Of Drosophila Melanogaster Rhoa Mutants During The Morphogenetic Process Of Head Involution

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ISBN : OCLC:1065525713
Genre :
File Size : 67.8 MB
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In the United States, three out of every 100 babies are born with a major type of birth defect. Human birth defects can be acquired during morphogenetic processes such as neurulation. A prominent morphogenetic process in the Drosophila model system is head involution. During head involution, embryonic epidermis moves anterior ward and simultaneously mouth structures move inward through a series of tucking, folding and migrations. These complex intracellular and intercellular shape changes are driven by RhoA signal transduction and may act on the actomyosin cytoskeleton. RhoA signal transduction is highly conserved, therefore Drosophila melanogaster is an effective model organism to study. Drosophila RhoA mutant alleles are embryonic lethal, failing in head involution; the resulting embryos lack cuticle at the anterior dorsal region and exhibit a "hole in the head" phenotype. I have studied the effect of RhoA on head involution in living Drosophila embryos by expression of an actin-binding Green Fluorescent Protein (GFP)-moesin fusion protein (SGMCA) followed by time-lapse confocal microscopy. First, wild type embryos were analyzed to determine the features of wild type head involution. Next, two null RhoA alleles, RhoAE3.10 and RhoAJ3.8 were analyzed. Homozygous RhoA embryos were derived from a RhoA/CyO, twi-GFP; SGMCA stock. The presence of the twi-GFP insert on the CyO balancer results in a characteristic high expression of GFP. Since homozygous RhoA embryos lack the CyO balancer, they do not express twi-GFP. Thus RhoA homozygotes can be unambiguously identified. Analysis of the time-lapse videos revealed that head involution dorsal ridge formation in RhoA mutants appears grossly normal. On the other hand the procephalon and clypeolabrum fail to drop and retract caudally as the dorsal fold moves anteriorward. The movement of the dorsal fold continues on the ventral side but is impeded by the dorsal side. Thus, the dorsal anterior side of the embryo is not encapsulated by cuticle secreting epidermis. This is consistent with the "hole in the head" phenotype observed in the embryonic cuticle.

The Development Of Drosophila Melanogaster

Author : Michael Bate
ISBN : 0879698993
Genre : Science
File Size : 78.51 MB
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The fruit fly Drosophila melanogaster offers the most powerful means of studying embryonic development in eukaryotes. New information from many different organ systems has accumulated rapidly in the past decade. This monograph, written by the most distinguished workers in the field, is the most authoritative and comprehensive synthesis of Drosophila developmental biology available and emphasizes the insights gained by molecular and genetic analysis. In two volumes, it is a lavishly illustrated, elegantly designed reference work illustrating principles of genetic regulation of embryogenesis that may apply to other eukaryotes.
Category: Science