Diagnostic Immunohistochemistry

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Monoclonal Antibodies In Diagnostic Immunohistochemistry

Author : Mark Wick
ISBN : 0824778383
Genre : Medical
File Size : 38.48 MB
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BRIEF OVERVIEW OF INTERMEDIATE FILAMENT PROTEINS -- NEUROFILAMENT PROTEINS -- GLIAL FILAMENT PROTEIN -- INTERPRETATION OF STUDIES OF HUMAN NERVOUS SYSTEM TUMORS USING ANTIBODIES TO NF AND GF PROTEINS -- FUTURE PROSPECTS FOR THE USE OF PROBES TO NF AND GF PROTEINS IN PATHOLOGY -- CONCLUSIONS -- APPENDIX: SPECIFICITY OF MONOCLONAL ANTIBODIES TO HUMAN NEUROFILAMENT AND GLIAL FILAMENT PROTEINS -- ACKNOWLEDGMENTS -- REFERENCES -- 6 Monoclonal Antibodies to Lymphorecticular and Myeloid Antigens -- METHODS UTILIZED WITH LYMPHOHEMATOPOIETIC MONOCLONAL ANTIBODIES -- T-CELL AND NATURAL KILLER CELL MONOCLONAL ANTIBODIES AND T-CELL MALIGNANCIES -- T-Cell Monoclonal Antibodies -- Natural Killer Cell Antibodies -- T-Cell Malignancies -- B-CELL MONOCLONAL ANTIBODIES AND B-CELL MALIGNANCIES -- B-Cell Monoclonal Antibodies -- B-Cell Malignancies -- Non-T Acute Lymphocytic Leukemia -- Small Noncleaved Cell Malignant Lymphoma -- Chronic Lymphocytic Leukemia and Small Lymphocytic Malignant Lymphoma -- Prolymphocytic Leukemia (Galton's Leukemia) -- Intermediate Differentiation Malignant Lymphoma -- Follicular Malignant Lymphoma with Small Cleaved and/or Large Cleaved Cells -- Diffuse Small Cleaved and Diffuse Mixed Small and Large Cell Malignant Lymphoma -- Diffuse Large Cell and Immunoblastic Malignant Lymphoma -- Hairy Cell Leukemia -- Multiple Myeloma and Plasmacytoid Lymphoma -- HODGKIN'S DISEASE -- MYELOID MONOCLONAL ANTIBODIES AND ACUTE AND CHRONIC MYELOID LEUKEMIA -- Myeloid Monoclonal Antibodies -- Acute Myeloid Leukemia -- Chronic Myelogenous Leukemia -- MONOCLONAL ANTIBODIES USED IN PARAFFIN-EMBEDDED SECTIONS -- Immunoglobulin -- Leu M1 -- LN-1 and LN-2 -- Leu 7 -- Others -- FUTURE DI RECTION -- REFERENCES -- 7 Monoclonal Antibodies to Human Milk Fat Globule Proteins
Category: Medical

Diagnostic Immunohistochemistry

Author : David J Dabbs
ISBN : 9781455700103
Genre : Medical
File Size : 56.10 MB
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Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin’s lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. This concise and complete resource is today’s indispensable guide to the effective use of immunohistochemical diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization. Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors. Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance. Features an expert author for each chapter to ensure coverage of the current state of the art. Provides guidance on the role of genomics in identifying genetic and molecular aspects of disease that may affect patient care and therapeutic approaches. Covers theranostic applications to enable you to evaluate therapeutic choices based on immunohistochemical results. Reflects the latest developments in the field through new chapters on molecular anatomic pathology and immunocytology, as well as updated chapters on immunohistology of the prostate, bladder, testis, and kidney and Non-Hodgkin’s lymphoma. Discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval. Presents key differential diagnoses boxes that provide tabular summaries of DDx and algorithms. Features discussions of ancillary anatomic molecular diagnostics as an adjunct to immunohistochemistry for a more well-rounded diagnostic approach.
Category: Medical

Diagnostic Immunohistochemistry E Book

Author : David J Dabbs
ISBN : 9780323551601
Genre : Medical
File Size : 64.15 MB
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User-friendly and concise, the new edition of this popular reference is your #1 guide for the appropriate use of immunohistochemical stains. Dr. David J. Dabbs and leading experts in the field use a consistent, organ system approach to cover all aspects of the field, with an emphasis on the role of genomics in diagnosis and theranostic applications that will better inform treatment options. Each well-written and well-researched chapter is enhanced with diagnostic algorithms, charts, tables, and superb, full-color histologic images, making this text a practical daily resource for all surgical pathologists. Features a systematic approach to the diagnostic entities of each organ system, including detailed differential diagnoses, diagnostic algorithms, and immunohistograms that depict immunostaining patterns of tumors. Covers many more antigens than other texts, and discusses antibody specifications with tables that convey information on uses, clones, vendors, sources, antibody titers, and types of antigen retrieval. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Contains new material on non-lymphoid malignancies, Hodgkin/non-Hodgkin lymphoma, and an expanded chapter on digital imaging and quantilative immunohistochemistry. Provides new grading schemes for several organs, along with new antibodies to cover more genomic immunohistochemistry applications. Offers more emphasis in the breast section of "eyes on" tissue for molecular/IHC prognostics compared to the current trend of gene-expression profiling of breast cancer.
Category: Medical

Diagnostic Immunohistochemistry

Author : Ronald A. DeLellis
ISBN : UOM:39015002408360
Genre : Diagnostic immunohistochemistry
File Size : 62.29 MB
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Category: Diagnostic immunohistochemistry

Diagnostic Immunohistochemistry Of The Skin

Author : Jean Kanitakis
ISBN : UOM:39015042792484
Genre : Architecture
File Size : 28.43 MB
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Dermato(patho)logists nowadays greatly rely on the progress of immunohistochemistry, both at the light and electronmicroscopic level. Immunohistochemical techniques not only represent a major diagnostic tool, but they also substantially contribute to our understanding of the aetiopathogenesisof skin diseases. This book, compiled by an international panel of expert dermatologists represents a concise, yet comprehensive, compendium highlighting the diagnostic and pathogenetic contributions of immunohistochemistry in dermatology.
Category: Architecture

Antigen Retrieval Immunohistochemistry Based Research And Diagnostics

Author : Shan-Rong Shi
ISBN : 111806030X
Genre : Science
File Size : 83.96 MB
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The most complete, up-to-date reference on antigen retrieval and immunohistochemistry An antigen is a substance that prompts the generation of antibodies and can cause an immune response. The antigen retrieval (AR) technique is in wide use across the globe, and is a critical technique used in medical diagnosis of disease, particularly clinical targeted cancer treatment. Antigen Retrieval Immunohistochemistry Based Research and Diagnostics discusses several scientific approaches to the standardization of quantifiable immunohistochemistry (IHC). Based on the development and application of AR by the editors, this volume summarizes recent achievements in AR-IHC and analyzes numerous cutting-edge issues for future research projects. Featuring contributions from a worldwide group of leading experts and research scientists in the field, this important work: Summarizes the key problems in the four fields of antigen retrieval Discusses the advances of AR techniques and their applications Provides practical methods and protocols in AR-IHC, such as extraction of nucleic acids and proteins for molecular analysis, cell/tissue sample preparation, and standardization and development of various techniques to meet the future needs of¿clinical and research molecular analysis Encourages further research in AR and IHC, particularly how AR methods might be employed for improved test performance and the development of greater reliability and reproducibility of IHC Includes an appendix of related laboratory protocols Antigen Retrieval Immunohistochemistry Based Research and Diagnostics is intended for clinical pathologists, molecular cell biologists, basic research scientists, technicians, and graduate students who undertake tissue/cell morphologic and molecular analysis and wish to use and extend the power of immunohistochemistry. It is also pertinent for most biotechnology companies majoring in development of IHC products. Wiley Series in Biomedical Engineering and Multi-Disciplinary Integrated Systems / Kai Chang, Series Editor
Category: Science

The Washington Manual Of Surgical Pathology

Author : Peter A. Humphrey
ISBN : 0781765277
Genre : Medical
File Size : 43.10 MB
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Presented in the renowned, fast-access format of other Washington Manual® titles, this excellent book is a practical guide to the clinical practice of surgical pathology. This valuable resource covers all aspects of surgical pathology for every organ and anatomic site, including gross examination and dissection; microscopic diagnosis of medical as well as surgical diseases; tumor classification; and tumor staging. Separate chapters are devoted to ancillary surgical pathology techniques, including immunohistochemistry, immunofluorescence microscopy, electron microscopy, frozen section diagnosis, flow cytometry, DNA and RNA based molecular methods, and imaging technologies. A companion Website offers the fully searchable text plus an image bank of more than 2700 figures.
Category: Medical

Phenotypic And Genotypic Diagnosis Of Malignancies

Author : Muin S. A. Tuffaha
ISBN : 9783527622399
Genre : Science
File Size : 73.33 MB
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Carefully designed as an easy and quick reference, this desktop manual is for working pathologists who need to determine the particular type of cancer they are dealing with in a patient. To this end, the book contains many large tables of information to allow a fast analysis of results, providing all the relevant information to diagnose the full range of different tumors in humans. Must-have content for all cancer pathologists.
Category: Science

Diagnostic Surgical Pathology Of The Head And Neck E Book

Author : Douglas R. Gnepp
ISBN : 9781437719512
Genre : Medical
File Size : 29.82 MB
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This resource is the authoritative guide to problematic areas of the head and neck for the surgical pathologist. With particular emphasis placed on diagnostic problems and differential diagnosis in addition to coverage of more common diagnostically straightforward lesions, you’ll get the most complete diagnostic picture possible. The updated second edition features new coverage and a more user-friendly layout. Features the most comprehensive collection of head and neck pathology specimens in one reference for comparison with your findings. Covers rare as well as common diagnoses to help you identify even the most obscure disease entities. Provides clinicopathologic correlations throughout to give you all the information you need to formulate a complete diagnostic report. Emphasizes differential diagnosis and avoiding diagnostic pitfalls so you can overcome difficult diagnostic challenges. Covers FNA cytology, molecular genetic techniques, and immunohistochemistry to present the most compete diagnostic picture possible. Presents a brand-new chapter on specimen handling to ensure effective processing and reporting of head and neck specimens. Features more than 1700 full-color illustrations that capture the pathologic and cytopathologic appearances of the full range of common and rare neoplastic and non-neoplastic lesions.
Category: Medical

Pathology Of Infectious Diseases E Book

Author : Gary W. Procop
ISBN : 9781455753840
Genre : Medical
File Size : 54.27 MB
Format : PDF
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Pathology of Infectious Diseases, by Gary W. Procop, MD, A Volume in the Foundations in Diagnostic Pathology Series, packs all of today's most essential information on infectious disease pathology into a compact, high-yield format! Well-organized and segmented by type of infectious organism, the book's pragmatic approach complemented by abundant full-color, high-quality photomicrographs and clinical photos, and at-a-glance tables makes it easy to access the information you need to quickly and accurately detect and identify pathogenic organisms. Chapters on immunohistochemical and molecular techniques as well as artifacts and pitfalls guide you to accurate detection and identifications. Quickly find the information you need thanks to a well-organized, user-friendly format with templated headings, detailed illustrations, at-a-glance tables, and segmentation by type of infectious organism—viral, bacterial, fungal, and parasitic. Avoid common problems that can lead to an incorrect diagnosis. A special section on artifacts and pitfalls shows you what to look for. Get superb visual guidance from an abundance of full-color, high-quality photomicrographs and clinical photos. Employ the latest diagnostic advancements including immunohistochemical and molecular techniques. Learn from one of the very best. Dr. Gary W. Procop, one of the most outstanding young clinical pathologists in medical microbiology in American medicine, shares his vision about how new technologies may be used to rapidly identify pathogenic organisms and detect resistance to treatment regimens. Recognized for distinguished research contributions to the discipline of clinical microbiology, he was the recipient of the 2007 American Society for Microbiology (ASM) BD Award for Research in Clinical Microbiology and elected to the American Academy of Microbiology in recognition of his scientific achievements. Implement proven diagnostic approaches such as real-time PCR assays and pepticnucleic acid probes with guidance from the pioneer of these techniques!
Category: Medical

Diagnostic Pathology Of Infectious Disease E Book

Author : Richard L. Kradin
ISBN : 9781455705986
Genre : Medical
File Size : 76.97 MB
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Diagnostic Pathology of Infectious Disease presents a comprehensive, organ-based approach to the effective and accurate diagnosis of infectious diseases. Dr. Richard L. Kradin covers the latest information on H1N1, as well as the use of immunohistochemical stains, PCR, Immunoperoxidase, and other molecular techniques for a current representation of the field. High-quality, full-color illustrations and differential diagnosis tables accompany each lesion so you can quickly identify and diagnose whatever you see. This reference is an invaluable tool for the accurate diagnosis of any infectious disease—from the common to the most challenging. Covers the latest techniques in immunohistochemistry and molecular genetics integrated throughout the text for comprehensive information on all investigative contexts relevant to ensuring diagnostic accuracy. Emphasizes the host responses critical in differential diagnosis to serve as a second opinion when non-infectious diagnoses mimic and confound the diagnosis of infection. Provides a complete visual guide to suspect lesions through superb, high-quality, full-color illustrations of key aspects of various diseases that facilitate the rapid identification of biopsy specimen. Presents contents organized by organ as opposed to pathogen to more effectively address diagnostic and management issues. Features tables that list differential diagnosis for each lesion for quick summaries of key points in problem areas. Highlights morphological characteristics and landmarks of tissue samples throughout the text for easy access to information necessary for signing out specimen. Focuses on clinicopathologic features and correlations so you can deal with the diagnostic problems you face every day.
Category: Medical

Issues In Pathology Diagnostics And Disease 2011 Edition

Author :
ISBN : 9781464965425
Genre : Medical
File Size : 56.17 MB
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Issues in Pathology, Diagnostics, and Disease: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pathology, Diagnostics, and Disease. The editors have built Issues in Pathology, Diagnostics, and Disease: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pathology, Diagnostics, and Disease in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pathology, Diagnostics, and Disease: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Category: Medical

Handbook Of Immunohistochemistry And In Situ Hybridization Of Human Carcinomas

Author : M. A. Hayat
ISBN : 9780080495194
Genre : Science
File Size : 51.27 MB
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The various cell types have traditionally been recognized and classified according to their appearance in the light microscope following the process of fixing, processing, sectioning, and staining tissues that is known as histology. Classical histology has been augmented by immunohistochemistry (the use of specific antibodies to stain particular molecular species in situ). Immunohistochemistry has allowed the identification of many more cell types than could be visualized by classical histology, particularly in the immune system and among the scattered hormone-secreting cells of the endocrine system. Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas discusses all aspects of immunohistochemistry and in situ hybridization technologies and the important role they play in reaching a cancer diagnosis. It provides step-by-step instructions on the methods of additional molecular technologies such as DNA microarrays, and microdissection, along with the benefits and limitations of each method. The topics of region-specific gene expression, its role in cancer development and the techniques that assist in the understanding of the molecular basis of disease are relevant and necessary in science today, ensuring a wide audience for this book. The only book available that translates molecular genetics into cancer diagnosis Provides the readers with tools necessary to perform and optimize sensitive, powerful techniques, including immunohistochemistry and fluorescence in situ hybridization, used in tumor diagnosis Written by experts in this field, the book provides theoretical considerations as well as practical approaches to carry out effectively these techniques Offers suggestions, tips, cautions, and guidelines to avoid artifacts and misdiagnosis Introduces new techniques to detect genes and proteins involved in the initiation and progression of cancer Covers the latest developments and a wide range of applications to the detection of antigens and single-copy DNA and RNA Written in a uniform format, each chapter includes Introduction, Materials required, step-by-step detailed Methods, Results, Discussion, and comprehensive up-to-date References
Category: Science

Handbook Of Practical Immunohistochemistry

Author : Fan Lin
ISBN : 9781493915781
Genre : Medical
File Size : 61.8 MB
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In a conceptually current, quick-reference, Question & Answer format, the second edition of Handbook of Practical Immunohistochemistry: Frequently Asked Questions continues to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 10,000 tumors and normal tissue to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. Fully revised and updated from the first edition, the new features of the second edition include over 200 additional questions or revised questions with an IHC panel to answer each question; over 250 new color photos and illustrations; over 20 new useful biomarkers; hundreds of new references; several new chapters to cover phosphoproteins, rabbit monoclonal antibodies, multiplex IHC stains, overview of predictive biomarkers, and integration of IHC into molecular pathology; many new coauthors who are international experts in a related field; many updated IHC panels using Geisinger IHC data collected from over 10,000 tumors and normal tissues; and updated appendices containing detailed antibody information for both manual and automated staining procedures. Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, Second Edition will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.
Category: Medical

Methods Of Cancer Diagnosis Therapy And Prognosis

Author : M. A. Hayat
ISBN : 9048129184
Genre : Medical
File Size : 54.97 MB
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This volume presents a detailed survey of cancers. This volume was written by of various methodologies related to diag- 94 oncologists representing 13 countries. nosis, therapy, and prognosis of ovar- Their practical experience highlights their ian cancer, renal cancer, urinary bladder writings, which should build and further cancer, and cervical uterine cancer, while the endeavors of the readers in this imp- the already published Volumes 1–5 detail tant area of disease. The text of each c- similar aspects of breast, lung, prostate, cer type is divided into subheadings for liver, gastrointestinal, colorectal, and bil- the convenience of the readers. It is my iary tract carcinomas. hope that the current volume will join the It is well established that cancer is the preceding volumes of this series for assi- deadliest of human diseases. The follow- ing in the more complete understanding ing estimated global incidence of seven of globally relevant cancer syndromes. types of cancers discussed in this volume There exists a tremendous, urgent demand indicated the seriousness of this malig- by the public on the scientific community nancy. to address cancer prevention, diagnosis, treatment, and hopefully cures. Cervical uterine cancer 493,342 I am grateful to the contributors for their Urinary bladder cancer 357,000 promptness accepting my suggestions. I respect their dedication and diligent work Leukemia 300,522 in sharing their invaluable knowledge with Renal cancer 208,480 the public through this series.
Category: Medical

Application Of Monoclonal Antibodies In Tumor Pathology

Author : Dirk J. Ruiter
ISBN : 9789400932999
Genre : Medical
File Size : 37.28 MB
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The development of monoclonal antibodies to human tumor associated antigens has greatly facilitated the application of immunohistochemical techniques to analyze surgically removed tissues. During the last few years this approach has been utilized by a progressively increasing number of investigators to analyze malignant cells. Although monoclonal antibodies to tumor associated antigens have not become yet routine reagents in immunopathology, they have provided new information which could not be obtained with conventional antisera or histochemical procedures. The following are representative examples. TUmor associated antigens have been identified which display a restricted distribution in normal tissues and therefore may represent useful markers for radio imaging and appropriate targets for immunotherapy. In spite of undetec table differences with conventional histopathological approaches hetero geneity has been found in the antigenic profile of tumor cells within a lesion, in autologous lesions removed from different anatomic sites from a given patient and in lesions removed from different patients. Phenotypes of tumor cells have been identified which correlate with the biology of tumor cells and with the clinical course of the disease. From a practical view point the use of monoclonal antibodies in immunopathology has enhanced interactions between pathologists and immunologists, as exemplified by the present book. Such interactions have contributed to the application of basic research to clinical problems. The chapter of this book discuss investigations performed with monoclonal antibodies to antigens expressed by various types of normal and malignant human cells.
Category: Medical

Rosai And Ackerman S Surgical Pathology E Book

Author : Juan Rosai
ISBN : 9780323088046
Genre : Medical
File Size : 74.33 MB
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Rosai and Ackerman’s Surgical Pathology delivers the authoritative guidance you need to overcome virtually any challenge in surgical pathology. Recognized globally for his unmatched expertise, preeminent specialist Juan Rosai, MD brings you state-of-the-art coverage of the latest advancements in immunohistochemistry, genetics, molecular biology, prognostic/predictive markers, and much more - equipping you to effectively and efficiently diagnose the complete range of neoplastic and non-neoplastic entities. Efficiently review the clinical presentation, gross and microscopic features, ultrastructural and immunohistochemical findings, differential diagnosis, therapy, and prognosis for virtually every pathologic entity. Compare your findings to more than 3,300 outstanding illustrations that capture the characteristic presentation of every type of lesion. Avoid diagnostic pitfalls using Dr. Rosai's expert observations on what to look for, what to be careful about, and which presentations can be misleading. Find quick answers on tumor staging, quality control procedures, and the handling of gross specimens through valuable appendices. Make optimal use of all the very latest advances including our increased understanding of the genetic basis of inherited and acquired disease, the newest molecular genetic and immunohistochemical techniques, and the most recent WHO disease classification schemes.
Category: Medical