Comprehensive Toxicology

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Comprehensive Toxicology

Author : I.G. Sipes
ISBN : CORNELL:31924073491072
Genre : Medical
File Size : 29.63 MB
Format : PDF
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Comprehensive Toxicology - the first comprehensive reference work in toxicology, is an in-depth, state-of-the-art review of toxicology of unrivalled quality. It is designed to encompass investigation from a molecular level to the intact organism. Presented in a 13-volume printed form.
Category: Medical

Comprehensive Toxicology

Author : I. Glenn Sipes
ISBN : CORNELL:31924073493003
Genre : Medical
File Size : 75.2 MB
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Category: Medical

Comprehensive Toxicology Volume 7

Author : R.S. Goldstein
ISBN : 0080429726
Genre : Medical
File Size : 76.56 MB
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Current concepts on mechanisms mediating chemically induced nephrotoxicity are rapidly evolving. This volume is focused on capturing this rapidly growing field by providing a comprehensive, state-of-the-art review of renal pathophysiology and toxicology, written by internationally recognized experts in the field. The first section of this volume is designed to provide the reader with the needed background information; including an overview of clinical nephrotoxicity, the anatomy and physiology of the kidney and urinary bladder, renal transport mechanisms, xenobiotic metabolism, and in vivo and in vitro methods used to assess renal toxicity. Our current state of knowledge on the pathophysiology and biochemistry of acute renal failure, renal and urinary bladder carcinogenesis, and immune-mediated renal injury are covered in detail. The role of vasoactive substances, cell adhesion molecules, oxidative stress/antioxidants and membrane changes in composition/fluidity in mediating nephrotoxic, and ischemic renal injury are reviewed and provide the reader with the conceptual framework for understanding key mechanisms of renal injury. In addition, the role of gene expression and growth factors in renal injury and repair are discussed. The response of each of the major segments of the nephron to a toxic insult is discussed in detail; with chapters devoted to mechanisms mediating injury to the glomerulus, proximal tubule, collecting duct and papilla and the tubulointerstitium. Various nephrotoxicants are discussed in detail with an emphasis on pathophysiologic and morphologic effects and mechanisms of toxicity. Wherever possible, the relevance of experimental findings to human exposure is covered.
Category: Medical

Comprehensive Toxicology Volume 12

Author : G.T. Bowden
ISBN : 0080429777
Genre : Medical
File Size : 70.75 MB
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The purpose of Volume 12 is to provide a comprehensive overview of the field of chemical and radiation carcinogenesis with particular emphasis on molecular mechanisms. The actions of various chemical carcinogens as well as ultraviolet and ionizing radiation are discussed in the context of the multistage process of both experimental and human carcinogenesis. Background information concerning the target genes for the genetic and epigenetic modulation by carcinogens are covered. These target genes include proto-oncogenes, tumor suppressor genes, and effector genes. Various classes of carcinogens including tumor initiating, promoting, and progressing agents are discussed in terms of how they bring about critical alterations in the target genes. The functional role of these gene alterations are covered in the context of the various phenotypic changes associated with each stage of carcinogenesis. Finally, strategies for intervening with the multistep process of carcinogenesis through chemoprevention are discussed. Wherever possible the relevancy of more basic findings with experimental model systems to human carcinogenesis is emphasized.
Category: Medical

Comprehensive Toxicology Volume 3

Author : F.P. Guengerich
ISBN : 0080429688
Genre : Science
File Size : 30.80 MB
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This volume deals with the enzymatic processes involved in the biotransformation of toxic and potentially toxic chemicals. The first section provides introductory material on general aspects of history, regulation, mechanism, inhibition, and stimulation of the enzymes in this group. The bulk of the volume is comprised of chapters dealing with the current status of enzymes involved in oxidation, reduction, hydrolysis, and conjugation of xenobiotic chemicals. Each chapter is organized to cover the current status of enzyme multiplicity and nomenclature, gene and protein structure, regulation, catalytic mechanism, substrate specificity, human studies, and relevance to issues in toxicology.
Category: Science

Comprehensive Toxicology

Author : I. Glenn Sipes
ISBN : CORNELL:31924073492807
Genre : Medical
File Size : 57.71 MB
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Category: Medical

Comprehensive Toxicology

Author : I. Glenn Sipes
ISBN : CORNELL:31924089427052
Genre : Molecular toxicology
File Size : 59.85 MB
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Category: Molecular toxicology

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Author :
ISBN : UCSC:32106014991829
Genre : Academic libraries
File Size : 80.12 MB
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Category: Academic libraries