COMPLEX SYSTEMS IN MEDICINE

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Network Medicine

Author : Albert-László Barabási
ISBN : 0674545532
Genre : HEALTH & FITNESS
File Size : 53.2 MB
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"Network medicine, a new field which developed from the application of systems biology approaches to human disease, embraces the complexity of multifactorial influences on disease, which can be driven by non-linear effects and molecular and statistical interactions. The development of comprehensive and affordable Omics platforms provides the data types for network medicine, and graph theory and statistical physics provide the theoretical framework to analyze networks. While network medicine provides a fundamentally different approach to understanding disease etiology, it will also lead to key differences in how diseases are treated--with multiple molecular targets that may require manipulation in a coordinated, dynamic fashion. Much remains to be learned regarding the optimal approaches to integrate different Omics data types and to perform network analyses; this book provides an overview of the progress that has been made and the challenges that remain."--
Category: HEALTH & FITNESS

Philosophy Of Complex Systems

Author :
ISBN : 0080931227
Genre : Philosophy
File Size : 47.33 MB
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The domain of nonlinear dynamical systems and its mathematical underpinnings has been developing exponentially for a century, the last 35 years seeing an outpouring of new ideas and applications and a concomitant confluence with ideas of complex systems and their applications from irreversible thermodynamics. A few examples are in meteorology, ecological dynamics, and social and economic dynamics. These new ideas have profound implications for our understanding and practice in domains involving complexity, predictability and determinism, equilibrium, control, planning, individuality, responsibility and so on. Our intention is to draw together in this volume, we believe for the first time, a comprehensive picture of the manifold philosophically interesting impacts of recent developments in understanding nonlinear systems and the unique aspects of their complexity. The book will focus specifically on the philosophical concepts, principles, judgments and problems distinctly raised by work in the domain of complex nonlinear dynamical systems, especially in recent years. -Comprehensive coverage of all main theories in the philosophy of Complex Systems -Clearly written expositions of fundamental ideas and concepts -Definitive discussions by leading researchers in the field -Summaries of leading-edge research in related fields are also included
Category: Philosophy

Unifying Themes In Complex Systems

Author : Ali A. Minai
ISBN : 9783540358664
Genre : Science
File Size : 75.65 MB
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In recent years, scientists have applied the principles of complex systems science to increasingly diverse fields. The results have been nothing short of remarkable. The Third International Conference on Complex Systems attracted over 400 researchers from around the world. The conference aimed to encourage cross-fertilization between the many disciplines represented and to deepen our understanding of the properties common to all complex systems.
Category: Science

Complex Systems Science In Biomedicine

Author : Thomas Deisboeck
ISBN : 0387335323
Genre : Medical
File Size : 25.56 MB
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Complex Systems Science in Biomedicine Thomas S. Deisboeck and J. Yasha Kresh Complex Systems Science in Biomedicine covers the emerging field of systems science involving the application of physics, mathematics, engineering and computational methods and techniques to the study of biomedicine including nonlinear dynamics at the molecular, cellular, multi-cellular tissue, and organismic level. With all chapters helmed by leading scientists in the field, Complex Systems Science in Biomedicine's goal is to offer its audience a timely compendium of the ongoing research directed to the understanding of biological processes as whole systems instead of as isolated component parts. In Parts I & II, Complex Systems Science in Biomedicine provides a general systems thinking perspective and presents some of the fundamental theoretical underpinnings of this rapidly emerging field. Part III then follows with a multi-scaled approach, spanning from the molecular to macroscopic level, exemplified by studying such diverse areas as molecular networks and developmental processes, the immune and nervous systems, the heart, cancer and multi-organ failure. The volume concludes with Part IV that addresses methods and techniques driven in design and development by this new understanding of biomedical science. Key Topics Include: • Historic Perspectives of General Systems Thinking • Fundamental Methods and Techniques for Studying Complex Dynamical Systems • Applications from Molecular Networks to Disease Processes • Enabling Technologies for Exploration of Systems in the Life Sciences Complex Systems Science in Biomedicine is essential reading for experimental, theoretical, and interdisciplinary scientists working in the biomedical research field interested in a comprehensive overview of this rapidly emerging field. About the Editors: Thomas S. Deisboeck is currently Assistant Professor of Radiology at Massachusetts General Hospital and Harvard Medical School in Boston. An expert in interdisciplinary cancer modeling, Dr. Deisboeck is Director of the Complex Biosystems Modeling Laboratory which is part of the Harvard-MIT Martinos Center for Biomedical Imaging. J. Yasha Kresh is currently Professor of Cardiothoracic Surgery and Research Director, Professor of Medicine and Director of Cardiovascular Biophysics at the Drexel University College of Medicine. An expert in dynamical systems, he holds appointments in the School of Biomedical Engineering and Health Systems, Dept. of Mechanical Engineering and Molecular Pathobiology Program. Prof. Kresh is Fellow of the American College of Cardiology, American Heart Association, Biomedical Engineering Society, American Institute for Medical and Biological Engineering.
Category: Medical

Complex Systems And Networks

Author : Jinhu Lü
ISBN : 9783662478240
Genre : Technology & Engineering
File Size : 21.85 MB
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This elementary book provides some state-of-the-art research results on broad disciplinary sciences on complex networks. It presents an in-depth study with detailed description of dynamics, controls and applications of complex networks. The contents of this book can be summarized as follows. First, the dynamics of complex networks, for example, the cluster dynamic analysis by using kernel spectral methods, community detection algorithms in bipartite networks, epidemiological modeling with demographics and epidemic spreading on multi-layer networks, are studied. Second, the controls of complex networks are investigated including topics like distributed finite-time cooperative control of multi-agent systems by applying homogenous-degree and Lyapunov methods, composite finite-time containment control for disturbed second-order multi-agent systems, fractional-order observer design of multi-agent systems, chaos control and anticontrol of complex systems via Parrondos game and many more. Third, the applications of complex networks provide some applicable carriers, which show the importance of theories developed in complex networks. In particular, a general model for studying time evolution of transition networks, deflection routing in complex networks, recommender systems for social networks analysis and mining, strategy selection in networked evolutionary games, integration and methods in computational biology, are discussed in detail.
Category: Technology & Engineering

Uncertainty And Surprise In Complex Systems

Author : Reuben R. McDaniel
ISBN : 3540237739
Genre : Science
File Size : 88.39 MB
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Complexity science has been a source of new insight in physical and social systems and has demonstrated that unpredictability and surprise are fundamental aspects of the world around us. This book is the outcome of a discussion meeting of leading scholars and critical thinkers with expertise in complex systems sciences and leaders from a variety of organizations, sponsored by the Prigogine Center at The University of Texas at Austin and the Plexus Institute, to explore strategies for understanding uncertainty and surprise. Besides contributions to the conference, it includes a key digest by the editors as well as a commentary by the late nobel laureate Ilya Prigogine, "Surprises in half of a century". The book is intended for researchers and scientists in complexity science, as well as for a broad interdisciplinary audience of both practitioners and scholars. It will well serve those interested in the research issues and in the application of complexity science to physical and social systems.
Category: Science

Understanding Leadership In Complex Systems

Author : Terje Andreas Tonsberg
ISBN : 9783319404455
Genre : Business & Economics
File Size : 73.53 MB
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This work proposes that Carl Menger’s Subjective Theory of Value (STV), and its subsequent elaboration by Ludwig von Mises as Praxeology, provides a useful alternative to more common methods in the study of action and social phenomena, and more specifically, to leadership in complex social systems. Rather than being based on rationality assumptions and algorithmic predictability, the STV emphasizes transient subjectivity shaped by a complex world of lacking information, mistakes, disequilibrium, uncertainty and attempted error correction that defy mathematization and exact prediction. As such, it is a framework to make sense of human action systems in terms of subjective understanding, learning, and uncertainty, rather than quantitative predictability. Accordingly, the aim of this work is to explain the STV as a general theory of action and to demonstrate its capability in developing adequate qualitative theory and to elaborate on some of the major topics that its implications raise with regard to leadership. The power of the method can be seen in that its procedure naturally branches out to facilitate an understanding of a broad selection of processes and may provide the basis for a universal theory of leadership.
Category: Business & Economics

Proceedings Of The Ninth International Conference On Dependability And Complex Systems Depcos Relcomex June 30 July 4 2014 Brun W Poland

Author : Wojciech Zamojski
ISBN : 9783319070131
Genre : Computers
File Size : 27.83 MB
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DepCoS – RELCOMEX is an annual series of conferences organized by Wrocław University of Technology to promote a comprehensive approach to evaluation of system performability which is now commonly called dependability. In contrast to classic analyses which were concentrated on reliability of technical resources and structures built from them, dependability is based on multi-disciplinary approach to theory, technology and maintenance of a system considered to be a multifaceted amalgamation of technical, information, organization, software and human (users, administrators, supervisors, etc.) resources. Diversity of processes being realized (data processing, system management, system monitoring, etc.), their concurrency and their reliance on in-system intelligence often severely impedes construction of strict mathematical models and calls for application of intelligent and soft computing methods. This book presents the proceedings of the Ninth International Conference on Dependability and Complex Systems DepCoS-RELCOMEX, which took place in Brunów Palace, Poland, from 30th June to 4th July, 2014. The articles selected for this volume illustrate the variety of topics that must be included in system dependability analysis: tools, methodologies and standards for modelling, design and simulation of the systems, security and confidentiality in information processing, specific issues of heterogeneous, today often wireless, computer networks or management of transportation networks.
Category: Computers

Complex Systems And Computational Biology Approaches To Acute Inflammation

Author : Yoram Vodovotz
ISBN : 9781461480082
Genre : Science
File Size : 89.6 MB
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The difficulty in achieving effective translation of basic mechanistic biomedical knowledge into effective therapeutics, is the greatest challenge in biomedical research. Nowhere is this more apparent than in the reductionist approaches to understanding and manipulating the acute inflammatory response in the settings of sepsis, trauma/hemorrhage, wound healing, and related processes. This book discusses complex systems and computational biology methods and approaches that have advanced sufficiently to allow for knowledge generation, knowledge integration, and clinical translation in the settings of complex diseases related to the inflammatory response. Well-regulated, self-resolving inflammation is necessary for the appropriate communication and resolution of infection and trauma, and for maintenance of proper physiology and homeostasis. In contrast, self-sustaining inflammation drives the pathobiology of the aforementioned diseases. It is now increasingly recognized that controlling and reprogramming inflammation in order to reap the benefits of this evolutionarily-conserved process is preferred to simply abolishing indiscriminately.
Category: Science