CLINICAL-PHARMACOKINETICS-AND-PHARMACODYNAMICS

Download Clinical-pharmacokinetics-and-pharmacodynamics ebook PDF or Read Online books in PDF, EPUB, and Mobi Format. Click Download or Read Online button to CLINICAL-PHARMACOKINETICS-AND-PHARMACODYNAMICS book pdf for free now.

Concepts In Clinical Pharmacokinetics

Author : Joseph T. DiPiro
ISBN : 9781585282418
Genre : Medical
File Size : 90.81 MB
Format : PDF, Docs
Download : 612
Read : 153

Short Description: This popular teaching and self-instructional text makes it easier than ever to acquire a strong foundation in the basic principles of pharmacokinetics.
Category: Medical

Rowland And Tozer S Clinical Pharmacokinetics And Pharmacodynamics Concepts And Applications

Author : Hartmut Derendorf
ISBN : 9781496385895
Genre : Medical
File Size : 33.5 MB
Format : PDF, ePub, Mobi
Download : 647
Read : 193

Updated with the latest clinical advances, Rowland and Tozer’s Clinical Pharmacokinetics and Pharmacodynamics, Fifth Edition , explains the relationship between drug administration and drug response, taking a conceptual approach that emphasizes clinical application rather than science and mathematics. Bringing a real-life perspective to the topic, the book simplifies concepts and gives readers the knowledge they need to better evaluate drug applications.
Category: Medical

Basic Pharmacokinetics And Pharmacodynamics

Author : Sara E. Rosenbaum
ISBN : 1118001052
Genre : Medical
File Size : 53.71 MB
Format : PDF, Kindle
Download : 567
Read : 164

With its clear, straightforward presentation, this text enables you to grasp all the fundamental concepts of pharmacokinetics and pharmacodynamics. This will allow you to understand the time course of drug response and dosing regimen design. Clinical models for concentration and response are described and built from the basic concepts presented in earlier chapters. Your understanding of the material will be enhanced by guided computer exercises conducted on a companion website. Simulations will allow you to visualize drug behavior, experiment with different dosing regimens, and observe the influence of patient characteristics and model parameters. This makes the book ideal for self-study. By including clinical models of agonism, indirect drug effects, tolerance, signal transduction, and disease progression, author Sara Rosenbaum has created a work that stands out among introductory-level textbooks in this area.You'll find several features throughout the text to help you better understand and apply key concepts: Three fictitious drugs are used throughout the text to progressively illustrate the development and application of pharmacokinetic and pharmacodynamic principles Exercises at the end of each chapter reinforce the concepts and provide the opportunity to perform and solve common dosing problems Detailed instructions let you create custom Excel worksheets to perform simple pharmacokinetic analyses Because this is an introductory textbook, the material is presented as simply as possible. As a result, you'll find it easy to gain an accurate, working knowledge of all the core principles, apply them to optimize dosing regimens, and evaluate the clinical pharmacokinetic and pharmacodynamic literature.
Category: Medical

Introduction To Pharmacokinetics And Pharmacodynamics

Author : Thomas N. Tozer
ISBN : 0781751497
Genre : Medical
File Size : 28.67 MB
Format : PDF, ePub, Docs
Download : 366
Read : 1186

This unique text helps students and healthcare professionals master the fundamentals of pharmacokinetics and pharmacodynamics. Written by distinguished international experts, it provides readers with an introduction to the basic principles underlying the establishment and individualization of dosage regimens and their optimal use in drug therapy. Up-to-date examples featuring currently prescribed drugs illustrate how pharmacokinetics and pharmacodynamics relate to contemporary drug therapy. Study problems at the end of each chapter help students and professionals gain a firm grasp of the material covered within the text.
Category: Medical

Applied Clinical Pharmacokinetics And Pharmacodynamics Of Psychopharmacological Agents

Author : Michael W. Jann
ISBN : 9783319278834
Genre : Medical
File Size : 55.69 MB
Format : PDF, Docs
Download : 876
Read : 966

This book is a comprehensive resource on psychotropic medications, detailing the latest methods for defining their characteristics, their use in different patient populations, and drug-drug interactions; an important collection of information forclinicians, students, researchers, and members of the pharmaceutical industry alike. The first section provides the foundational principles of these drugs. Mathematical modeling of parameters that affect their entryto,and exit from, the central nervous system (CNS) compartment are presented on an individual basis and then applied to target populations with specific disease states. Methods and characteristics that inform the transfer of these drugs from the laboratory bench to use in patient care are discussed, including imaging techniques, genetics and physiological barriers, such as the blood-brain barrier. The second section describes the characteristics of specific agents,nominally arranged intodifferent therapeutic categories and with reference crossover use in different disease states. The pharmacologic characteristics of different drug formulations are explored in the context of their ability to improve patient adherence. The third section focuses on drug-drug interactions.Psychotropic medications from different categories are frequently prescribed together,or alongside medications used to treat comorbid conditions, and the information provided is directly relevant to the clinic, as a result. The clinical application of pharmacokinetics and pharmacodynamics of CNS agents has made significant progress over the past 50 years and new information is reported by numerous publications in psychiatry, neurology, and pharmacology.Our understanding of the interrelationship between these medications, receptors, drug transporters, as well as techniques for measurement and monitoring their interactions,isfrequently updated. However, with information presented on a host of different platforms, and in different formats, obtaining the full picture can be difficult. This title aims to collate this information into a single source that can be easily interpreted and applied towards patient care by the clinical practitioner, and act as a reference for all others who have an interest in psychopharmacological agents.
Category: Medical

Clinical Pharmacokinetic And Pharmacodynamic Drug Interactions Associated With Antimalarials

Author : Tony K.L. Kiang
ISBN : 9783319105277
Genre : Medical
File Size : 37.89 MB
Format : PDF, Kindle
Download : 576
Read : 751

This comprehensive review provides a systematic, unbiased analysis, critique and summary of the available literature and generates novel clinical decision-making algorithms which can aid clinicians and scientists in practice management and research development. Potential mechanisms for the identified drug interactions are deduced from available preclinical and in vitro data which are interpreted in the context of the in vivo findings. Current limitations and gaps in the literature are summarized, and potential future research directions / experimentations are also suggested. In addition to the main objective to review the available clinical pharmacokinetic and pharmacodynamic drug interactions associated with WHO-recommended antimalarial drugs on the market today (i.e. chloroquine, amodiaquine, sulfadoxine, pyrimethamine, mefloquine, artemisinin, artemether, artesunate, dihydroartemisinin, artemotil, lumefantrine, primaquine, atovaquone, proguanil, piperaquine and quinine), this book also provides succinct chapter summaries on the epidemiology of malaria infection, diagnosis and therapeutics, in vivo pharmacology and chemistry, preclinical pharmacology, in vitro pharmacodynamics, in vitro reaction phenotyping, and in vitro drug-drug interaction data associated with the identified antimalarial drugs.
Category: Medical

Applied Pharmacokinetics Pharmacodynamics

Author : Michael E. Burton
ISBN : 0781744318
Genre : Medical
File Size : 62.77 MB
Format : PDF, ePub, Docs
Download : 921
Read : 1256

The definitive advanced-level clinical pharmacokinetics text is now in its Fourth Edition, with new emphasis on the relationship between pharmacokinetics and pharmacodynamics. Written by 70 leading researchers and practitioners, this book is a rigorous yet practical text on the application of pharmacokinetic methods, pharmacodynamic principles, and pharmacotherapeutic data for optimal, individualized drug therapy. This edition includes case studies that apply concepts to actual patient problems. New chapters cover tacrolimus, mycophenolic acid, sirolimus, antipsychotics, and critical evaluation of therapeutic drug monitoring methods. Other new features include more drawings and reference tables and an appendix on outcome studies with therapeutic drug monitoring.
Category: Medical

Clinical Pharmacokinetics Handbook

Author : Larry Bauer
ISBN : 007142542X
Genre : Medical
File Size : 77.76 MB
Format : PDF, Mobi
Download : 347
Read : 1262

Designed for pharmacists and clinicians responsible for adjusting drug dosages based on the patient blood serum concentrations and other parameters, this indispensable, portable reference offers a variety of ways to perform pharmacokinetic calculations. Features calculation methods, algorithms for choosing the best calculation method, and case studies.
Category: Medical