Cell Biology Playing Cards

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Carma Proteins Playing A Hand Of Four Cards

Author : Frédéric Bornancin
ISBN : 9782889630561
Genre :
File Size : 68.77 MB
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Some twenty years ago, the search began for B-cell lymphoma (BCL)-10 binding partners that connect via homophilic interaction with its N-terminal caspase recruitment domain (CARD) to induce nuclear factor-kappa B (NF-κB) activation. This effort led first to the identification of the protein CARD9. Soon afterwards, similar searches identified CARD10 (aka CARMA3), CARD11 (aka CARMA1) and CARD14 (aka CARMA2), as further BCL10 interactors. These discoveries paved the way for landmark progress in our understanding of NF-κB activation pathways downstream of several cell surface receptors on multiple cell types, focused particularly on antigen receptors on lymphocytes. An additional binding partner, called Mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), was also implicated in the CARD-BCL10 pathway. Since then, the resulting “CBM” complex has been recognized as a key node in signaling cascades leading to NF-κB activation, particularly in immune cells. Mouse models of genetic deficiencies for each CBM component provided the first evidence for their critical role in cell signaling. More recently, studies of human lymphoid malignancies and novel genetic disorders have revealed important new insights. Both gain- and loss-of-function mutations were identified, establishing these CARMA/CARD proteins as key regulators of proliferation and differentiation of immune and non-immune cells, and linking them to human disease. According to the genetic defect involved, dysregulation of CARMA/CARD pathways can lead to a broad spectrum of immune disorders, including severe immune deficiencies, lymphoproliferative disorders, psoriasis and atopy. The aim of this Research Topic is to summarize and update our current understanding of CARMA/CARD protein biology, from initial discoveries to the most recent insights. It focuses on CARD9 and the CARMA proteins CARD10, CARD11 and CARD14, from genetic, signaling and disease perspectives. BCL10 and MALT1 are also reviewed in this context as critical nodes for CBM signal relay and regulation. This Research Topic also aims to delineate the next key questions in the field to guide future research efforts.

Netter S Neuroscience Flash Cards

Author : David L. Felten
ISBN : 9780323375702
Genre : Medical
File Size : 55.21 MB
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Designed as a quick review tool, Netter's Neuroscience Flash Cards allow you to test your knowledge on the go! Fun, fast, and delivered in full color, this portable resource is a perfect study tool that covers neuroscience and neuroanatomy. Netter illustrations on the front and answers to labels plus explanatory text on the back emphasize the key organizational neurosciences principles and key clinical applications for an efficient yet in-depth review. It's ideal as a supplement to coursework, a prep tool for exams, if you're readying for rounds or clinical presentations, or if you'd simply like to enhance your knowledge of the subject. You may also be interested in: A companion textbook, Netter’s Atlas of Neuroscience, 3rd Edition, to which the cards are cross-referenced. Provides a quick review of the nervous system, making them ideal for use before exams or throughout clinical rotations, residency, or in practice. Allows you to make clinically important correlations in neuroanatomy, cell biology, and neurophysiology. Neuroimaging examples help assess your grasp of the subject. Includes visual and numbered labels on the front, and labeled answers/comments on the reverse. Clinical 'pearls' and helpful summaries of the results of neurological damage or injuries (peripheral nerves, cranial nerves, spinal cord and brain stem structures and regions, various syndromes, etc.) on the back of each card increase your understanding of the clinical implications of neuroscience concepts. Cross-referenced to Netter’s Atlas of Neuroscience, 3rd Edition for further information on any topic. Includes extensive imaging, cross-sectional anatomy, and vascular information. Features increased cellular and molecular coverage.
Category: Medical

The Journal Of Cell Biology

Author :
ISBN : UOM:39015018224462
Genre : Cells
File Size : 80.44 MB
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No. 2, pt. 2 of November issue each year from v. 19 (1963)-47 (1970) and v. 55 (1972)- contain the Abstracts of papers presented at the Annual Meeting of the American Society for Cell Biology, 3d (1963)-10th (1970) and 12th (1972)-
Category: Cells

The Biology Of Cells

Author : Herbert Stern
ISBN : UOM:39015004335439
Genre : Cell physiology
File Size : 49.20 MB
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Category: Cell physiology

Biology Science Materials

Author : Carolina Biological Supply Company
ISBN : UCSC:32106021023863
Genre : Biological apparatus and supplies
File Size : 39.87 MB
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Category: Biological apparatus and supplies

The Science Teacher

Author :
ISBN : UCSD:31822020278628
Genre : Science
File Size : 25.15 MB
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SCC Library has 1964-cur.
Category: Science

New Riders Official Internet Yellow Pages

Author : Christine Maxwell
ISBN : 1562054082
Genre : Computers
File Size : 66.23 MB
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The most comprehensive guide available to the services, information, and resources that the Internet has to offer. With over 10,000 listings, organized by topic and area of interest, this desk reference allows the reader to quickly and easily discover the world of the Internet.
Category: Computers

Environmental Biology

Author : R. F. Morgan
ISBN : WISC:89043242767
Genre : Biology
File Size : 73.97 MB
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Category: Biology

Crime Lab

Author : John Houde
ISBN : NWU:35556034217364
Genre : True Crime
File Size : 51.39 MB
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A guide to forensic analysis describes the processes, instruments, and techniques used by criminalists as they probe for clues among fibers, footprints, and DNA
Category: True Crime

Educational Monographs

Author : University of Birmingham. Institute of Education
ISBN : UCLA:L0053856795
Genre :
File Size : 64.26 MB
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Classics In Biology

Author : International University Society
ISBN : STANFORD:36105031282614
Genre : Science
File Size : 77.73 MB
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Category: Science

Structural And Functional Analysis Of The Interactions Between Beta Tubulin And Its Binding Partners

Author : Liru You
ISBN : CORNELL:31924089420362
Genre :
File Size : 65.8 MB
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The assembly of the microtubule-based bipolar mitotic spindle relies on a balance of forces acting on the spindle poles. In yeast, the primary outward force is generated by the kinesin-related proteins of the Bim C family that cross-link antiparallel interpolar microtubules and slide them past each other. Previously our lab identified Stu1p as a microtubule-associated protein essential for spindle assembly. I showed that Stu1p binds to the outside of the beta-tubulin molecule using alanine-scanning tub2 mutants. Stu1p is localized to the midregion of anaphase spindles. The temperature-sensitivity of stu1-5 can be suppressed by doubling the dosage of Cin8p, a yeast Bim C kinesin-related protein. Stu1p can also associate with itself in vivo. Taken together, these findings suggest that Stu1p binds directly to the interpolar microtubules of the mitotic spindle and contributes to the outward force on the spindle pole.


Author : Howard Madison Parshley
ISBN : UOM:39015069706193
Genre : Biology
File Size : 51.67 MB
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Category: Biology