Cardiac Drug Safety A Bench To Bedside Approach

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Cardiac Drug Safety

Author : Matthew J. Killeen
ISBN : 9789814317450
Genre : Medical
File Size : 30.9 MB
Format : PDF, Docs
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At present, over 120 medications have been withdrawn from the major global pharmaceutical markets due to potentially lethal unwanted effects on the heart, namely ventricular fibrillation. With recent FDA guidelines recommending stringent testing of new pharmaceuticals on the heart, the importance of cardiac electrophysiology is affecting an increasing number of professionals in a range of industries. This book will equip readers with a clear and solid foundation in the fundamentals of electrophysiology and pharmacology of the heart, explore clinical disorders and treatments and relate this to the research and development of new medicines.Representing an integrative bench to bedside approach to understanding this critical drug safety phenomenon, this book begins with a comprehensive review of the mechanisms responsible for drug-induced arrhythmia, followed by an in-depth discussion of the current preclinical and clinical recording techniques. Additionally, a complete assessment of current methods to stratify cardiac risk in drug development is included. Most importantly, the book develops and outlines the novel strategies and key frameworks that increase the cardiac drug safety and drive down the risk of novel biopharmaceutical products in the future. Contents: Physiology of the Heart; Introduction to Electrophysiology: History, Ion Channels, Important Concepts; Electrophysiology of the Heart; Studying Cardiac Electrophysiology in the Laboratory and Clinic; Electrical Disorders of the Heart: From Cell to Bedside; The Impact of Cardiac Electrophysiology on Drug Development: History, Current Tests (Regulations, Requirements) and Their Shortcomings; Case Studies; The Future of Cardiac Drug Safety: Strategies to Reduce Risk and Ensure Continued Safety.
Category: Medical

Heart Failure

Author : Douglas L. Mann
ISBN : UOM:39015052875088
Genre : Medical
File Size : 63.46 MB
Format : PDF
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Provides readers with a comprehensive bench-to-bench overview of the field of heart failure. Every attempt has been made to include novel chapters that have not heretofore been covered in traditional textbooks on heart failure. For example, one chapter addresses the new and emerging area of sleep-disordered breathing and heart. There are also unique chapters on the science and art of developing heart failure guidelines, as well as a chapter on clinical trial design in heart failure.
Category: Medical

Heart Failure

Author : José Marín-García
ISBN : 9781607611479
Genre : Medical
File Size : 54.95 MB
Format : PDF, Kindle
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Heart Failure (HF) is the final and common pathway of all cardiovascular diseases. Heart Failure: Bench to Bedside helps address a significant need to develop new paradigms and to identify novel therapeutic targets for this pervasive disease. An authoritative contribution to the field, this book provides a detailed description of new findings and emerging methodologies, as well as a critical clinical evaluation of the complex HF syndrome and future therapies. Heart Failure: Bench to Bedside includes a primer on gene profiling and bioenergetics of the normal heart and a discussion of the molecular, genetic, biochemical and cellular techniques critical to understanding HF. Further chapters discuss cardiac remodeling, oxidative stress, and alterations in other organs and systems that are often associated with HF. This book thoughtfully evaluates current and forthcoming diagnostic techniques and therapies, pharmaceutical and pharmacogenomic-based individualized medicine, gene and cell-based therapies, and the search for new frontiers. Heart Failure: Bench to Bedside presents a clear view of up-to-date approaches to clinical diagnosis and treatment, as well as offering insightful critiques of original and creative scientific thoughts on post-genomic HF research.
Category: Medical

Botanical Medicine

Author : Raymond Cooper
ISBN : PSU:000067166275
Genre : Medical
File Size : 50.76 MB
Format : PDF
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"Based loosely on the workshop Clinical Pharmacognosy: Contribution of Pharmacognosy to Clinical Trials of Botanicals and Dietary Supplements, held at the American Society of Pharmacognosy (ASP) meeting in Portland, Maine"--P. [xi].
Category: Medical

Genetics Of Stem Cells

Author : Yaoliang Tang
ISBN : 9780123984593
Genre : Medical
File Size : 88.32 MB
Format : PDF, Mobi
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This special volume of Progress in Molecular Biology and Translational Science focuses on the genetics of stem cells. Contributions from leading authorities Informs and updates on all the latest developments in the field
Category: Medical

Co Morbidities In Heart Failure An Issue Of Heart Failure Clinics E Book

Author : Faiez Zannad
ISBN : 9780323296953
Genre : Medical
File Size : 72.35 MB
Format : PDF, Kindle
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This issue of Heart Failure Clinics examines co-morbidities in patients with heart failure. Topics include hypertension, diabetes, pulmonary disorders, cardiorenal syndrome, anemia, depression, atrial fibrillation, obesity and cardiac cachexia, peripheral vascular disease, rheumatologic disorders, co-morbidities and polypharmacy, coronary artery disease, and clinical trials.
Category: Medical

Overweight And The Metabolic Syndrome

Author : George A. Bray
ISBN : 9780387321646
Genre : Medical
File Size : 49.3 MB
Format : PDF, Kindle
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This timely book provides an overview of topics related to obesity. These include associated health risks, childhood obesity, genetics, evaluation, treatment, behavioral strategies, and successes and failures in preventing obesity. The volume covers evaluation guidelines, different approaches to treatment, including diet, exercise, behavior, drugs, and surgery to deal with the current world-wide obesity epidemic.
Category: Medical


Author :
ISBN : UCLA:L0098923881
Genre :
File Size : 46.31 MB
Format : PDF, ePub, Mobi
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Kaplan S Cardiac Anesthesia E Book

Author : Joel A. Kaplan
ISBN : 9781437703597
Genre : Medical
File Size : 21.54 MB
Format : PDF, Kindle
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Optimize perioperative outcomes with Kaplan’s Cardiac Anesthesia! Dr. Joel L. Kaplan and a host of other authorities help you make the best use of the latest techniques and navigate your toughest clinical challenges. Whether you are administering anesthesia to cardiac surgery patients or to cardiac patients undergoing non-cardiac surgery, you’ll have the guidance you need to avoid complications and ensure maximum patient safety. Consult this title on your favorite e-reader, conduct rapid searches, and adjust font sizes for optimal readability. Compatible with Kindle®, nook®, and other popular devices. Update your understanding of cardiovascular and coronary physiology, and the latest advances in molecular biology and inflammatory response mechanisms. Master the newest approaches to perioperative assessment and management, including state-of-the art diagnostic techniques. Tap into the latest knowledge about 2D and 3D transesophageal echocardiography, anesthesia delivery for minimally invasive/robotic cardiac surgery, assist devices and artificial hearts, cardiac pacing, cardiac resynchronization therapy, ablation techniques, and more. Access the complete contents online at Expert Consult, plus additional online-only features including an ECG atlas...videos that demonstrate 2-D and 3-D TEE techniques in real time...and an Annual Year End Highlight from the Journal of Cardiovascular Anesthesia that’s posted each February. Clearly visualize techniques with over 800 full-color illustrations.
Category: Medical

Forthcoming Books

Author : Rose Arny
ISBN : UOM:39015054026961
Genre : American literature
File Size : 61.32 MB
Format : PDF
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Category: American literature

Acp Medicine

Author : David C. Dale
ISBN : 0970390289
Genre : Medical
File Size : 82.97 MB
Format : PDF
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ACP Medicine is the product of a new partnership between the American College of Physicians and WebMD Professional Publishing. Developed from WebMD Scientific American Medicine it provides a continually updated, comprehensive internal medicine reference.
Category: Medical