Biophysical Methods For Biotherapeutics

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Biophysical Methods For Biotherapeutics

Author : Tapan K. Das
ISBN : 9780470938430
Genre : Medical
File Size : 46.61 MB
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With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development. • Helps formulation and analytical scientists in pharma and biotech better understand and use biophysical methods • Chapters organized according to the sequential nature of the drug development process • Helps formulation, analytical, and bioanalytical scientists in pharma and biotech better understand and usestrengths and limitations of biophysical methods • Explains how to use biophysical methods, the information obtained, and what needs to be presented in a regulatory filing, assess impact on quality and immunogenicity • With a focus on practical applications of biophysical techniques, this book links fundamental biophysics to the process of biopharmaceutical development.
Category: Medical

Biophysical Techniques In Drug Discovery

Author : Angeles Canales
ISBN : 9781788012867
Genre : Science
File Size : 60.10 MB
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Biophysical techniques are used in many key stages of the drug discovery process including in screening for new receptor ligands, in characterising drug mechanisms, and in validating data from biochemical and cellular assays. This book provides an overview of the biophysical methods applied in drug discovery today, including traditional techniques and newer developments. Perspectives from academia and industry across a spectrum of techniques are brought together in a single volume. Small and biotherapeutic approaches are covered and strengths and limitations of each technique are presented. Case studies illustrate the application of each technique in real applied examples. Finally, the book covers recent developments in areas such as electron microscopy with discussions of their possible impact on future drug discovery. This is a go-to volume for biophysicists, analytical chemists and medicinal chemists providing a broad overview of techniques of contemporary interest in drug discovery.
Category: Science

Biophysics For Therapeutic Protein Development

Author : Linda O. Narhi
ISBN : 9781461443162
Genre : Medical
File Size : 73.76 MB
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This book can be used to provide insight into this important application of biophysics for those who are planning a career in protein therapeutic development, and for those outside this area who are interested in understanding it better. The initial chapters describe the underlying theory, and strengths and weaknesses of the different techniques commonly used during therapeutic development. The majority of the chapters discuss the applications of these techniques, including case studies, across the product lifecycle from early discovery, where the focus is on identifying targets, and screening for potential drug product candidates, through expression and purification, large scale production, formulation development, lot-to-lot comparability studies, and commercial support including investigations.
Category: Medical

Developability Of Biotherapeutics

Author : Sandeep Kumar
ISBN : 1482246139
Genre : Medical
File Size : 33.72 MB
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Several computational methodologies and biophysical techniques are being adapted and examples of successful designs are beginning to emerge. Simultaneously, there is a growing awareness of improving clinical trial designs using statistical and mathematical modeling to prevent unnecessary drug candidate failures. This book details the applications of computational and molecular modeling techniques towards affordable biopharmaceutical drug development at both pre-clinical and clinical stages.
Category: Medical

Biophysical Characterization Of Critical Physicochemical Properties Of Therapeutic Monoclonal Antibody Formulations

Author : Jannatun Nayem
ISBN : 9798672104683
Genre :
File Size : 59.82 MB
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Manufacturing challenges and pharmacokinetics often limit the development of new mAb therapeutics. While the characterization of primary through quaternary structure is crucial for understanding their biochemical functionalities and efficacy, the quaternary structure, interactions, and dynamics of therapeutic mAb proteins and the formulation excipients in both solid state and solution are crucial for understanding their stability during manufacturing, formulation, long-time storage, and drug delivery.
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Immunogenicity Of Therapeutic Biological Products

Author : Fred Brown
ISBN : UOM:39015056835765
Genre : Medical
File Size : 43.72 MB
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Immune responses to biological products have occurred with many approved therapeutics. The proportion of patients mounting an immune response is product dependent and the clinical significance of the immune response also varies with the nature of the product. Some products can induce production of significant levels of antibodies without any detectable effect on the activity of the product. However, neutralizing antibodies can attenuate the efficacy of the treatment and significant adverse clinical events can be seen if neutralizing antibodies cross-react with patients' endogenous proteins. Prediction of immunogenicity includes the use of bio-informatics to predict T-cell epitopes, T-cell stimulation assays and in vivo transgenic animal models. Approaches to prevent immunogenicity involve methods to design out immunogenic sequences, protein pegylation and inducing tolerance. Current methods for assessing and detecting immunogenicity include in vivo animal models, antibody assays and biological assays. The advantages and disadvantages of the various methods illustrate that a battery of tests is required to appropriately monitor patients' immune responses during clinical trials.
Category: Medical

Info Source

Author : Canada
ISBN : UIUC:30112075731973
Genre : Administrative agencies
File Size : 45.49 MB
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Category: Administrative agencies

Nature

Author : Sir Norman Lockyer
ISBN : UIUC:30112075228673
Genre : Electronic journals
File Size : 44.19 MB
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Category: Electronic journals

New Scientist

Author :
ISBN : NWU:35558005787813
Genre :
File Size : 74.48 MB
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Research Report

Author :
ISBN : CHI:51838609
Genre : Cancer
File Size : 40.74 MB
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Category: Cancer

Directory Of Graduate Research

Author : American Chemical Society. Committee on Professional Training
ISBN : UCSD:31822036045805
Genre : Biochemistry
File Size : 22.26 MB
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Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Category: Biochemistry