Biochemistry Of Arachidonic Acid Metabolism

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Biochemistry Of Arachidonic Acid Metabolism

Author : William E.M. Lands
ISBN : 9781461325970
Genre : Medical
File Size : 52.31 MB
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Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E, (POE,), prostacyclin (POI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lip oxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids.
Category: Medical
Biochemistry of Arachidonic Acid Metabolism
Language: en
Pages: 442
Authors: William E.M. Lands
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer
Metabolic Fate of Arachidonic Acid
Language: en
Pages: 52
Authors: Rabindra Karki
Categories: Medical
Type: BOOK - Published: 2015-02-11 - Publisher: LAP Lambert Academic Publishing

This Book depicts the metabolic fate of Arachidonic acid in general through three major pathways viz. Lipoxygenase, Cyclooxygenase & Cytochrome P450 monoxygenase pathways. However, special emphasis has been given to the Lipoxygenase pathway. The book takes into account of the recent findings in the above pathways for instance discovery of
Arachidonic Acid Metabolism by Liver and Hepatoma
Language: en
Pages:
Authors: S. J. Hewertson, University of Brunel
Categories: Medical
Type: BOOK - Published: 1987 - Publisher:

Books about Arachidonic Acid Metabolism by Liver and Hepatoma
Arachidonic Acid Metabolism and Tumor Initiation
Language: en
Pages: 200
Authors: Lawrence J. Marnett
Categories: Medical
Type: BOOK - Published: 2012-12-06 - Publisher: Springer Science & Business Media

Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer
Aspects of Uterine Arachidonic Acid Metabolism
Language: en
Pages:
Authors: A. Morgan, University of Brunel
Categories: Medical
Type: BOOK - Published: 1983 - Publisher:

Books about Aspects of Uterine Arachidonic Acid Metabolism