Arachidonate Remodeling And Inflammation

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Arachidonate Remodeling And Inflammation

Author : Alfred N. Fonteh
ISBN : 9783034878487
Genre : Medical
File Size : 46.72 MB
Format : PDF
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Arachidonic acid (AA) and other 20 or 22-carbon polyunsaturated fatty acids (PUFAs) are precursors of lipid mediators of inflammation known as eicosanoids. These mediators are critical in disease processes and in regulating normal cell function. Remodeling is important in maintaining homeostasis and in regulating cell function by dictating how PUFAs are converted to lipid mediators of inflammation. Thus, PUFA remodeling is a critical process in the biosynthesis of a multitude of mediators, and understanding this process will unravel better therapeutic targets for controlling inflammatory diseases such as asthma and Alzheimer’s disease. AA metabolism is described in an integrated context linking the remodeling processes with the biosynthesis of mediators and diseases. By following the movement of the substrate (AA), the volume describes how upstream biosynthetic pathways influence the formation of lipid mediators of inflammation, showing the metabolic interrelationship between all AA-derived mediators.
Category: Medical


Author : Robert R. Ruffolo, Jr.
ISBN : 0849394732
Genre : Medical
File Size : 74.29 MB
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Inflammation: Mediators and Pathways reviews key developments in the field of inflammation. It focuses on novel pathways of inflammation that have only recently surfaced. All the topics covered are currently the subject of intense investigation, and all contributors are established investigators in the field.
Category: Medical

Microarrays In Inflammation

Author : Andreas Bosio
ISBN : 3764383348
Genre : Medical
File Size : 86.6 MB
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This book summarizes the most advanced technical aspects covering all steps for a thorough application of microarrays to inflammation topics – from sample generation to data analysis. In addition selected examples of successful applications of microarrays in major fields of inflammation research are presented. The book will help a researcher or clinician to plan, perform and analyze or to critically review microarray experiments related to inflammation research.
Category: Medical

Endothelial Dysfunction And Inflammation

Author : Shauna Dauphinee
ISBN : 9783034601689
Genre : Medical
File Size : 86.37 MB
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Endothelial dysfunction is broadly defined as a disruption of the balance between vasoactive mediators and a propensity towards an inflammatory state. This volume provides an overview of the fields of endothelial dysfunction and inflammation through the discussion of topics ranging from the molecular biology of activated endothelial cells to the endothelium in inflammatory disease and therapeutic approaches targeting endothelial dysfunction. Topics include: Heterogeneity of the endothelium during inflammation, oxidative stress and endothelial dysfunction, biology and regulation of nitric oxide in inflammatory pathologies, endothelial dysfunction in inflammatory diseases, such as diabetes and atherosclerosis and Clinical methods used to assess endothelial function. This book brings together basic and clinical research to assist the reader in bridging connections from bench-to-bedside. Written by expert researchers in the fields of endothelial biology, inflammation research and clinical science, it serves as a useful reference for academic and industrial researchers, clinicians, and trainees in the medical profession.
Category: Medical

Cytokines And Joint Injury

Author : Wim B. van den Berg
ISBN : 9783034878838
Genre : Medical
File Size : 58.96 MB
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The purpose of this volume in the Progress in Inflammation Research series is to provide the biomedical and clinical researcher with a state-of-the-art insight in the role of cytokines in joint inflammation and joint destruction. This is of relevance for better understanding of key processes in diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). Apart from the impact of old and novel cytokines on joint tissues, the various chapters address the issue of targeted therapy with biological response modifiers and future interventions with carefully designed inhibitors. Spe cial attention is given to elements of synovial cell activation, cell-cell interaction, cytokine interplay as well as mechanisms of cartilage destruction and bone erosion. In addition to an outline of the role of established cytokines, such as TNF, IL-l and IL-6, new information is given on the novel cytokines IL-15, IL-17 and IL-18 and their positioning in the complex cytokine interplay. Cytokine regulation of destructive enzymes, RANKL, the endogenous inhibitor OPG and their crucial roles as central players in joint erosion are highlighted. Together, the chapters provide a complete and balanced view on pivotal cytokines and joint pathology.
Category: Medical

Recent Advances In The Pathophysiology Of Copd

Author : Trevor T. Hansel
ISBN : 9783034879392
Genre : Medical
File Size : 38.82 MB
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Chronic obstructive pulmonary disease (COPD) ranges amongst the commonest diseases in the world. The relentless progression of the disease causes a pressing need for a better understanding of and therapies for COPD. This volume provides state-of-the-art information on the pathophysiology of COPD including an outlook on new therapies. It is of interest to researchers and clinicians in academia as well as in the pharmaceutical industry.
Category: Medical


Author : Donald Armstrong
ISBN : UOM:39015075686421
Genre : Science
File Size : 90.62 MB
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This guide on methods and protocols of lipidomics covers a wide array of topics including isolation techniques, structural analysis, lipid rafts, lipid trafficking and profiling, biomarkers, lipid peroxidation, software tools and bioinformatics.
Category: Science

Therapeutic Approaches To Inflammatory Diseases

Author : Inflammation Research Association. International Conference
ISBN : UOM:39015015330270
Genre : Anti-inflammatoires - Congrès
File Size : 45.27 MB
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Co-sponsored by the Inflammatory Research Association and the Arthritis Foundation, the Fourth International Conference of the Inflammation Research Association yielded new methods and insight from many of the top minds in rheumatology. This outstanding proceedings volume includes contributions by such noted researchers as K. Frank Austen, Timothy A. Springer, and David Wofsy, and offers the most current information on topics from autoimmunity to pharmacotherapy. Including papers on both rheumatic and non-rheumatic illness, plus numerous illustrations, this is an excellent resource for researchers with an interest in the cause and control of inflammation.
Category: Anti-inflammatoires - Congrès

Prostaglandins And Related Compounds

Author : Bengt Samuelsson
ISBN : 0781702380
Genre : Medical
File Size : 75.3 MB
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This volume contains more than 100 papers presented by leading investigators worldwide at the Ninth International Conference on Prostaglandins and Related Compounds. These presentations cover the entire spectrum of contemporary research on eicosanoids and highlight the applications of this research in the development and therapeutic use of new drugs. Major sections of the book review the most recent advances in the study of phospholipases, cyclooxygenase pathways, lipoxygenase pathways, cytochrome P450 and other oxygenase products, and isoprostanes. Other sections focus on receptors and on the role of eicosanoids in immunology, inflammation, cell differentiation and proliferation, blood cells and the vascular wall, and the respiratory, cardiovascular, and renal systems. Close attention is given to recent research on platelet-activating factor (PAF) and nitric oxide. Also included are extensive updates on ocular prostaglandin research and discussions of the use of prostaglandin E[subscript 1] in the management of erectile dysfunction. This volume is an essential reference for pharmacologists, biochemists, cell biologists, and physiologists, as well as for clinicians treating the wide range of diseases in which eicosanoids play a role.
Category: Medical

Mediators Of The Inflammatory Process

Author : Peter M. Henson
ISBN : UOM:39015019576027
Genre : Medical
File Size : 32.3 MB
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Inflammation can be defined as a generalized, nonspecific but beneficial response of tissues to injury. The essential, protective role of inflammation can easily be seen in the life-threatening genetic diseases in which key elements of the inflammatory reaction are missing or defective. The drive to understand the underlying control processes and underlying mechanisms derives, however, more from the pathological perspective than from elucidating defense of the host to injury, and has prompted an enormous effort on the part of the pharmaceutical industry to develop efficient antagonists and inhibitors of the molecules involved in these reactions; the inflammatory mediators. This volume is intended by the authors to provide information on groups of mediators of inflammation in general, and where possible to stimulate interest and comments on the possibilities for participation of these communication molecules, mediators, in the complex but fascinating process of inflammation.
Category: Medical


Author :
ISBN : UCLA:L0098927502
Genre : Allergy
File Size : 38.10 MB
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Category: Allergy