THE FORGOTTEN CURE THE PAST AND FUTURE OF PHAGE THERAPY

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The Forgotten Cure

Author : Anna Kuchment
ISBN : 9781461402503
Genre : Medical
File Size : 21.34 MB
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Traces the story of bacteriophages from Paris, where they were discovered in 1917, through breakthroughs stemming from phage research, to today's resurgent research, spearheaded by biotech startups and physicians.
Category: Medical

The Forgotten Cure

Author : Anna Kuchment
ISBN : 9781461402510
Genre : Medical
File Size : 76.39 MB
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This book fills a void. Never before has a comprehensive history of phage therapy—a once-neglected, now resurgent field—been written. Kuchment writes from the perspective of the eager student of history for the common reader.
Category: Medical

The Forgotten Cure

Author : Anna Kuchment
ISBN : 1489986812
Genre : Medical
File Size : 67.52 MB
Format : PDF, Kindle
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This book fills a void. Never before has a comprehensive history of phage therapy—a once-neglected, now resurgent field—been written. Kuchment writes from the perspective of the eager student of history for the common reader.
Category: Medical

Viruses Vs Superbugs

Author : T. Häusler
ISBN : 9780230552289
Genre : Science
File Size : 58.67 MB
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Each year thousands of people die from bacteria resistant to antibiotics. Alternative drugs are urgently needed. A surprising ray of hope from the past are viruses that kill bacteria, but not us. Award-winning science journalist Thomas Häusler investigates how these long-forgotten cures may help sick people today.
Category: Science

The Bacteriophages

Author : Richard Calendar
ISBN : 9781468454246
Genre : Medical
File Size : 34.22 MB
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It has been 10 years since Plenum included a series of reviews on bacte riophages, in Comprehensive Virology. Chapters in that series contained physical-genetic maps but very little DNA sequence information. Now the complete DNA sequence is known for some phages, and the se quences for others will soon follow. During the past 10 years two phages have come into common use as reagents: A phage for cloning single copies of genes, and Ml3 for cloning and DNA sequencing by the dideoxy termi nation method. Also during that period the use of alternative sigma fac tors by RNA polymerase has become established for SPOl and T4. This seems to be a widely used mechanism in bacteria, since it has been implicated in sporulation, heat shock response, and regulation of nitro gen metabolism. The control of transcription by the binding of A phage CII protein to the -35 region of the promoter is a recent finding, and it is not known how widespread this mechanism may be. This rapid progress made me eager to solicit a new series of reviews. These contributions are of two types. Each of the first type deals with an issue that is exemplified by many kinds of phages; chapters of this type should be useful in teaching advanced courses. Chapters of the second type provide comprehensive pictures of individual phage families and should provide valuable information for use in planning experiments.
Category: Medical

Last Help Phage Therapy

Author : Paul Enders
ISBN : 1534629289
Genre :
File Size : 69.23 MB
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When the first antibiotic was discovered, it revolutionized medicine, and in many ways, the world. Illnesses that had previously decimated countless suddenly had a treatment, and those antibiotics were used judiciously - and have been ever since. Our Modern Medicine is so inundated with antibiotics that the bacteria and micro-organisms they were first created to destroy have found their own defense, a resistance to these duper drugs that have made them super bugs... and we need a way to fight back. While many look to the future creation of new, stronger antibiotics, the answer may very well lie in our own medical past. In 1915, two enterprising scientists discovered that bacteriophages were present in the stools and bodies of sick patients right before they began to recover. When they found that bacteriophages were also present wherever bacteria grew, it prompted a new line of thought - and the formation of Phage Therapy. This insightful and scientifically accurate book takes us on a journey 100 + years in the making, from the very beginnings of Phage Therapy, through its many varieties and applications and then on to the future of this medical practice - and how the medical breakthrough we have all been waiting for may have already happened.
Category:

Natural Defense

Author : Emily Monosson
ISBN : 9781610917186
Genre : Political Science
File Size : 47.15 MB
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We rely on chemical cures to keep our bodies free from disease and our farm fields free from bugs and weeds. While human and agricultural health are rarely considered together, both are based on the same ecology, and both are being threatened by organisms that have evolved to resist our antibiotics and pesticides. Fortunately scientists are finding new solutions that work with, rather than against, nature. There are viruses that bust apart bacteria; insect pheromones that throw crop destroying moths into a misguided sexual frenzy; plant genes edited to protect against disease; and a resurgence of the ancient practice of fecal transplants. In this hopeful book, Monosson offers a fascinating look into the future of natural defenses.
Category: Political Science

Bacteriophages

Author : Martha R. J. Clokie
ISBN : UOM:39015075645476
Genre : Medical
File Size : 32.17 MB
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Ranging from the evolution of pathogenicity to oceanic carbon cycling, the many and varied roles that bacteriophages play in microbial ecology and evolution have inspired increased interest within the scientific community. This book pulls together the vast body of knowledge and expertise from top international bacteriophage researchers to provide both classical and state-of-the-art molecular techniques. With its well-organized modular design, Volume 1 examines a multitude of topics, including the isolation of phages, morphological and molecular characterization, and interaction with bacteria. Volume 2 examines a multitude of topics, including the bacteriophage genomics, metagenomics, transcriptomics, and proteomics, along with applied bacteriophage biology. Written in the highly successful Methods in Molecular Biology series format, chapters consist of brief introductions to the subject, lists of the necessary materials and reagents, readily reproducible laboratory protocols, and a Notes section which details tips on troubleshooting and avoiding known pitfalls.
Category: Medical

Thinking Like A Phage

Author : Merry Youle
ISBN : 0990494314
Genre : Bacteriophages
File Size : 43.5 MB
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Phages are the most numerous life forms on Earth. Nevertheless, many people remain unaware of this dynamic, invisible world, and likewise of the challenges expertly met by every successful phage. This engaging book relates the ingenious tactics of 21 featured phages as they go about their viral work and replicate inside microbial cells.
Category: Bacteriophages

Life In Our Phage World

Author : Forest Rohwer
ISBN : 0990494306
Genre : Bacteriophages
File Size : 36.76 MB
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We share the Earth with more than 10,000,000,000,000,000,000,000,000,000,000 phages. Everywhere they thrive, from well-fed guts to near-boiling acidic springs, from cryoconite holes to endolithic fissures. They travel from one microbial host to the next as virions, their genetic weapons packaged inside a protective protein shell. If you could lay all of these nanoscopic phage virions side-by-side, the line-up would stretch over 42 million light years. Through their daily shenanigans they kill or collaborate with their microbial hosts to spur microbial evolution and maintain ecosystem functioning. We have learned much about them since their discovery by Frederick Twort a century ago. They also taught us that DNA, not protein, is the hereditary material, unraveled the triplet genetic code, and offered their enzymes as indispensible tools for the molecular biology revolution. More contributions will be forthcoming since the vast majority of phages await discovery. Phage genomes harbor the world's largest cache of unexplored genetic diversity, and we now have the equipment needed to go prospecting. Although there are field guides to birds, insects, wild flowers, even Bacteria, there was no such handbook to guide the phage explorer. Forest Rohwer decided to correct this oversight, for novice and expert alike, and thus was born Life in Our Phage World. A diverse collection of 30 phages are featured. Each phage is characterized by its distinctive traits, including details about its genome, habitat, lifestyle, global range, and close relatives. The beauty of its intricate virion is captured in a pen-and-ink portrait by artist Benjamin Darby. Each phage also stars in a carefully researched action story relating how that phage encounters, exploits, kills, or otherwise manipulates its host. These behaviors are imaginatively illustrated by fine artist Leah L. Pantea. Eight researchers that work closely with phages also relate their experiences as inhabitants of the phage world. Rohwer has years of first-hand experience with the phage multitudes in ecosystems ranging from coral reefs to the human lung to arctic waters. He pioneered the key metagenomic methods now widely used to catalog and characterize Earth's microbial and viral life. Despite research advances, most people, many scientists included, remain unaware of the ongoing drama in our phage world. In anticipation of 2015, the centennial of phage discovery, Forest assembled a cadre of writers, artists, scientists, and a cartographer and set them to work. The result? This alluring field guide-a feast for the imagination and a celebration of phage diversity."
Category: Bacteriophages