RISING PLAGUE THE GLOBAL THREAT FROM DEADLY BACTERIA AND OUR DWINDLING ARSENAL TO FIGHT THEM

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Rising Plague

Author : Brad Spellberg
ISBN : 9781615929481
Genre : Social Science
File Size : 75.68 MB
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Foreword by David Gilbert, MD, Past President of the Infectious Diseases Society of AmericaWhen we live in a world where crisis seems to be the norm, it''s hard to distinguish between those issues or events that worry us, those that hurt us and those that kill us. Rapidly developing drug resistance in death-causing microbes is killing us. And it''s getting worse each passing day. Spellberg''s book is a powerful and compelling journey into the antibiotic resistance problem written for doctors, scientists and any lay-person who loves their family and cares about their friends. This book explains the problem, its causes and potential solutions in a personal, compelling and easy to understand manner. It''s a must read for everyone.-Michael T. Osterholm, PhD, MPH, Director, Center for Infectious Disease Research and Policy; Former Associate Director of the Department of Homeland Security''s National Center for Food Protection and Defense; Director, Minnesota Center of Excellence for Influenza Research and Surveillance; Professor, Division of Environmental Health Sciences, School of Public Health; Adjunct Professor, Medical SchoolUsing a compelling series of clinical anecdotes, Dr. Spellberg demonstrates how the development of resistance in bacteria has steadily eroded the effectiveness of antibiotics, arguably the most important life-saving drugs developed by the pharmaceutical industry in the twentieth century. Unfortunately, as the levels of resistance in bacteria increase, research and development of new drugs to combat these resistant organisms is plummeting. In this clearly written book, Dr. Spellberg provides a cogent explanation for this paradox and delineates a series of logical steps that can be employed to deal with this worldwide public health problem.-Robert C. Moellering, Jr., M.D., Shields Warren-Mallinckrodt Professor of Medical Research, Harvard Medical SchoolAntibiotic-resistant microbes infect more than 2 million Americans and kill over 100,000 each year. They spread rapidly, even in such seemingly harmless places as high school locker rooms, where they infect young athletes. And throughout the world, many more people are dying from these infections. Astoundingly, at the same time that antibiotic resistant infections are skyrocketing in incidence-creating a critical need for new antibiotics-research and development of new antibiotics has ground to a screeching halt!In Rising Plague, Dr. Brad Spellberg-an infectious diseases specialist and member of a national task force charged with attacking antibiotic resistant infections-tells the story of this potentially grave public health crisis. The author shares true and very moving patient stories to emphasize the terrible frustration he and his colleagues have experienced while attempting to treat untreatable infections, not to mention the heart-break and tragedy that many of these patients'' families had to endure.Dr. Spellberg corrects the nearly universal misperception that physician misuse of antibiotics and dirty hospitals are responsible for causing antibiotic-resistant infections. He explains the true causes of antibiotic resistance and of the virtual collapse of antibiotic research and development. Most important, he advocates ways to reverse this dire trend and instead bolster the production of desperately needed new and effective antibiotics.He also warns against complacency induced by the decades-old assumption that some miracle drug will always be available to ensure the continuation of our antibiotic era. If we do nothing, we run the risk of inviting a bleak future when infectious diseases will once again reign supreme. Then many of the medical breakthroughs that we now take for granted-from routine surgery and organ transplants to intensive care and battlefield medicine-might all be threatened.This crucial and timely book is lucidly written in terms that everyone can understand. It issues a call to action, explaining how, through a strong and concerted effort, w
Category: Social Science

Making Parents

Author : Charis Thompson
ISBN : 0262201569
Genre : Science
File Size : 71.17 MB
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Reproductive technologies, says Thompson, are part of the increasing tendency to turn social problems into biomedical questions and can be used as a lens to see the resulting changes in the relations between science and society."--Jacket.
Category: Science

Unlocked

Author : John Scalzi
ISBN : 9781466871793
Genre : Fiction
File Size : 83.4 MB
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Discover the history of Haden's Syndrome, the virus that created the world of John Scalzi's inventive near-future thrillers Lock In and Head On, in the prequel novella Unlocked. Not long from now, a virus will sweep the globe. Most will suffer no worse than flu-like symptoms, but an unlucky one percent will be changed forever. Hundreds of millions become "locked in", awake, aware, but completely unable to control their bodies. This is the story of the doctors, scientists, engineers, politicians, and heroes who remade the world. It is the story of the chaotic outbreak, the fight for a cure, the changes that followed. It is an oral history, straight from the mouths of those who survived the most dynamic period in human history. At the Publisher's request, this title is being sold without Digital Rights Management Software (DRM) applied.
Category: Fiction

The Protest Psychosis

Author : Jonathan M. Metzl
ISBN : 9780807085936
Genre : Psychology
File Size : 36.99 MB
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A powerful account of how cultural anxieties about race shaped American notions of mental illness The civil rights era is largely remembered as a time of sit-ins, boycotts, and riots. But a very different civil rights history evolved at the Ionia State Hospital for the Criminally Insane in Ionia, Michigan. In The Protest Psychosis, psychiatrist and cultural critic Jonathan Metzl tells the shocking story of how schizophrenia became the diagnostic term overwhelmingly applied to African American protesters at Ionia—for political reasons as well as clinical ones. Expertly sifting through a vast array of cultural documents, Metzl shows how associations between schizophrenia and blackness emerged during the tumultuous decades of the 1960s and 1970s—and he provides a cautionary tale of how anxieties about race continue to impact doctor-patient interactions in our seemingly postracial America. From the Trade Paperback edition.
Category: Psychology

Biopunk

Author : Marcus Wohlsen
ISBN : 9781101476352
Genre : Science
File Size : 53.6 MB
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Bill Gates recently told Wired that if he were a teenager today, he would be hacking biology. "If you want to change the world in some big way," he says, "that's where you should start-biological molecules." The most disruptive force on the planet resides in DNA. Biotech companies and academic researchers are just beginning to unlock the potential of piecing together life from scratch. Champions of synthetic biology believe that turning genetic code into Lego-like blocks to build never-before-seen organisms could solve the thorniest challenges in medicine, energy, and environmental protection. But as the hackers who cracked open the potential of the personal computer and the Internet proved, the most revolutionary discoveries often emerge from out-of-the-way places, forged by brilliant outsiders with few resources besides boundless energy and great ideas. In Biopunk, Marcus Wohlsen chronicles a growing community of DIY scientists working outside the walls of corporations and universities who are committed to democratizing DNA the way the Internet did information. The "biohacking" movement, now in its early, heady days, aims to unleash an outbreak of genetically modified innovation by making the tools and techniques of biotechnology accessible to everyone. Borrowing their idealism from the worlds of open-source software, artisinal food, Internet startups, and the Peace Corps, biopunks are devoted advocates for open-sourcing the basic code of life. They believe in the power of individuals with access to DNA to solve the world's biggest problems. You'll meet a new breed of hackers who aren't afraid to get their hands wet, from entrepreneurs who aim to bring DNA-based medical tools to the poorest of the poor to a curious tinkerer who believes a tub of yogurt and a jellyfish gene could protect the world's food supply. These biohackers include: -A duo who started a cancer drug company in their kitchen -A team who built an open-source DNA copy machine -A woman who developed a genetic test in her apartment for a deadly disease that had stricken her family Along with the potential of citizen science to bring about disruptive change, Wohlsen explores the risks of DIY bioterrorism, the possibility of genetic engineering experiments gone awry, and whether the ability to design life from scratch on a laptop might come sooner than we think.
Category: Science

Fast Food Nation

Author : Eric Schlosser
ISBN : 9780547750330
Genre : Business & Economics
File Size : 55.23 MB
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Explores the homogenization of American culture and the impact of the fast food industry on modern-day health, economy, politics, popular culture, entertainment, and food production.
Category: Business & Economics

Boards Wards For Usmle Steps 2 3

Author : Carlos Ayala
ISBN : 9781451144062
Genre : Medical
File Size : 23.2 MB
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Established as an essential resource for medical students preparing for clinical rotations and the USMLE, Boards and Wards for USMLE Steps 2 & 3 is now in its updated Fifth Edition! Written in a succinct, high-yield outline format, it provides broad coverage of all key medical subspecialties in a user-friendly and portable format.
Category: Medical

6 Nightmares

Author : Anthony Lake
ISBN : 9780759520288
Genre : Political Science
File Size : 33.15 MB
Format : PDF
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Part important warning, part riveting memoir, former National Security Advisor Anthony Lake paints six terrifying scenarios that threaten our country's safety & shows how the government is prepared to face them - & how it is not.Though we live in a time of peace, serious threats to our national security lie just beyond the horizon. In Six Nightmares, former National Security Advisor Anthony Lake examines six major threats to America's safety that could arise from global terrorism, the proliferation of nuclear weapons & other serious risks. Weaving in firsth& views of key recent decisions, he shows how these threats could become real, how the government is prepared to face them & the alarming ways in which it is not.
Category: Political Science

The Antibiotic Paradox

Author : Stuart B. Levy
ISBN : 9781489960429
Genre : Medical
File Size : 87.90 MB
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Category: Medical

The Ethics Of Genetic Engineering

Author : Roberta M. Berry
ISBN : 9781135195915
Genre : Medical
File Size : 42.52 MB
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Human genetic engineering may soon be possible. The gathering debate about this prospect already threatens to become mired in irresolvable disagreement. After surveying the scientific and technological developments that have brought us to this pass, The Ethics of Genetic Engineering focuses on the ethical and policy debate, noting the deep divide that separates proponents and opponents. The book locates the source of this divide in differing framing assumptions: reductionist pluralist on one side, holist communitarian on the other. The book argues that we must bridge this divide, drawing on the resources from both encampments, if we are to understand and cope with the distinctive problems posed by genetic engineering. These problems, termed "fractious problems," are novel, complex, ethically fraught, unavoidably of public concern, and unavoidably divisive. Berry examines three prominent ethical and political theories – utilitarianism, Kantianism, and virtue ethics – to consider their competency in bridging the divide and addressing these fractious problems. The book concludes that virtue ethics can best guide parental decision making and that a new policymaking approach sketched here, a "navigational approach," can best guide policymaking. These approaches enable us to gain a rich understanding of the problems posed and to craft resolutions adequate to their challenges.
Category: Medical