RADIOTHERAPY TREATMENT PLANNING LINEAR QUADRATIC RADIOBIOLOGY

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Radiotherapy Treatment Planning

Author : J. Donald Chapman
ISBN : 9781439862605
Genre : Science
File Size : 58.33 MB
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Understand Quantitative Radiobiology from a Radiation Biophysics Perspective In the field of radiobiology, the linear-quadratic (LQ) equation has become the standard for defining radiation-induced cell killing. Radiotherapy Treatment Planning: Linear-Quadratic Radiobiology describes tumor cell inactivation from a radiation physics perspective and offers appropriate LQ parameters for modeling tumor and normal tissue responses. Explore the Latest Cell Killing Numbers for Defining Iso-Effective Cancer Treatments The book compiles radiation mechanism information from biophysical publications of the past 50 years, addressing how ionizing radiation produces the killing of stem cells in human tumors. It presents several physical and chemical parameters that can modulate the radiation response of clonogenic cells in tumors. The authors describe the use of the LQ model in basic radiation mechanism studies with cells of relatively homogeneous radiation response and then extend the model to the fitting of survival data generated with heterogeneous cell populations (tumors). They briefly discuss how to use the LQ model for predicting tumor (local) control probability (TCP) and normal tissue complication probability (NTCP). The book also examines potential molecular targets related to alpha- and beta-inactivation and gives suggestions for further molecular characterizations of these two independent processes. Develop Efficacious, Patient-Friendly Treatments at Reduced Costs Focusing on quantitative radiobiology in LQ formulation, this book assists medical physicists and radiation oncologists in identifying improved cancer treatments. It also encourages investigators to translate potentially improved radiotherapy schedules based on TCP and NTCP modeling into actual patient benefit.
Category: Science

Radiation Biology For Medical Physicists

Author : C. S. Sureka
ISBN : 9781351649827
Genre : Medical
File Size : 44.78 MB
Format : PDF
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This book is designed to convey as much information as possible in a concise and simple way to make it suitable for students, researchers and clinical medical physicists. Better meanings, codes and examples are included. Most of the basics are also covered for easy reference along with a glossary of objective-type questions. Upon completion of this textbook, the readers will gather knowledge about the physics, chemistry and biology of the human body towards cancer treatment using radiation.
Category: Medical

Alternate Fractionation In Radiotherapy

Author : Mark Trombetta
ISBN : 9783319511986
Genre : Medical
File Size : 69.79 MB
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This book, written by leading international experts, describes alternate fractionation strategies in which technology-driven precise targeting and dosing allow for improved conformance and decreased volumes, with concordant lessening of toxicity, reduction in treatment time, and lower overall health care expense. The aim is to provide the advanced clinician with an up-to-date evidence-based reference that will assist in the delivery of enhanced patient care in daily practice. Traditional multi-week fractionation schedules were established at a time when the inclusion of relatively large amounts of normal tissue was unavoidable owing to the lack of accurate target localization during treatment. Such schedules are time and resource consuming, difficult for patients, and expensive. Nevertheless, acceptance of alternate fractionation strategies has been slow in some countries. The paradigm is, however, changing as evidence accumulates to demonstrate improved local control, equivalence of tolerance, or both. In documenting these alternate strategies, this book will be of value for radiation oncologists, medical physicists, and oncologists worldwide.
Category: Medical

A Guide To Outcome Modeling In Radiotherapy And Oncology

Author : Issam El Naqa
ISBN : 9780429840357
Genre : Science
File Size : 41.65 MB
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This book explores outcome modeling in cancer from a data-centric perspective to enable a better understanding of complex treatment response, to guide the design of advanced clinical trials, and to aid personalized patient care and improve their quality of life. It contains coverage of the relevant data sources available for model construction (panomics), ranging from clinical or preclinical resources to basic patient and treatment characteristics, medical imaging (radiomics), and molecular biological markers such as those involved in genomics, proteomics and metabolomics. It also includes discussions on the varying methodologies for predictive model building with analytical and data-driven approaches. This book is primarily intended to act as a tutorial for newcomers to the field of outcome modeling, as it includes in-depth how-to recipes on modeling artistry while providing sufficient instruction on how such models can approximate the physical and biological realities of clinical treatment. The book will also be of value to seasoned practitioners as a reference on the varying aspects of outcome modeling and their current applications.
Category: Science

Practical Radiotherapy Planning Fourth Edition

Author : Ann Barrett
ISBN : 9781444113112
Genre : Medical
File Size : 60.71 MB
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Planning is a critical stage of radiotherapy. Careful consideration of the complex variables involved and critical assessment of the techniques available are fundamental to good and effective practice. First published in 1985, Practical Radiotherapy Planning has, over three editions, established itself as the popular choice for the trainee raditation oncologist and radiographer, providing the 'nuts and bolts' of planning in a practical and accessible manner. This fourth edition encompasses a wealth of new material, reflecting the radical change in the practice of radiotherapy in recent years. The information contained within the introductory chapters has been expanded and brought up to date, and a new chapter on patient management has been added. CT stimulators, MLC shieldings and dose profiles, principles of IMRT, and use of MRI, PET and ultrasound are all included, amongst other new developments in this field. The aim of the book remains unchanged. Complexity of treatment planning has increased greatly, but the fourth edition continues to emphasise underlying principles of treatment that can be applied for conventional, conformal and novel treatments, taking into account advances in imaging and treatment delivery.
Category: Medical

Stereotactic Radiosurgery And Stereotactic Body Radiation Therapy

Author : Stanley H. Benedict
ISBN : 9781439841983
Genre : Science
File Size : 61.73 MB
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Written by internationally known experts in the field, Stereotactic Radiosurgery and Stereotactic Body Radiation Therapy examines one of the fastest-developing subspecialties within radiation oncology. These procedures deliver large doses of radiation in one to five sessions to a precisely determined target. Often these techniques have proven to be as or more effective than traditional radiation therapy techniques, while at the same time being cost-efficient and convenient for the patient. These techniques, however, require careful planning, specialized equipment, and well-trained staff. This volume provides a cutting-edge look at the biological and technical underpinnings of SRS and SBRT techniques. It includes a history of the development of SRS and SBRT; clinical applications of the techniques; dedicated devices for delivering precisely shaped, high doses of radiation; use of in-room imaging for treatment planning and treatment guidance; immobilization techniques for accurate targeting; and future developments that will continue to evolve and refine existing techniques. A valuable introduction to those just learning about these specialized techniques, and an ideal reference for those who are already implementing them, this book covers a wide variety of topics, with clear discussions of each aspect of the technology employed.
Category: Science

Leibel And Phillips Textbook Of Radiation Oncology E Book

Author : Richard Hoppe
ISBN : 9781437737752
Genre : Medical
File Size : 51.12 MB
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Stay on top of the latest scientific and therapeutic advances with the new edition of Leibel and Phillips Textbook of Radiation Oncology. Dr. Theodore L. Phillips, in collaboration with two new authors, Drs. Richard Hoppe and Mack Roach, offers a multidisciplinary look at the presentation of uniform treatment philosophies for cancer patients emphasizing the "treat for cure" philosophy. You can also explore the implementation of new imaging techniques to locate and treat tumors, new molecularly targeted therapies, and new types of treatment delivery. Supplement your reading with online access to the complete contents of the book, a downloadable image library, and more at expertconsult.com. Gather step-by-step techniques for assessing and implementing radiotherapeutic options with this comprehensive, full-color, clinically oriented text. Review the basic principles behind the selection and application of radiation as a treatment modality, including radiobiology, radiation physics, immobilization and simulation, high dose rate, and more. Use new imaging techniques to anatomically locate tumors before and during treatment. Apply multidisciplinary treatments with advice from experts in medical, surgical, and radiation oncology. Explore new treatment options such as proton therapy, which can facilitate precise tumor-targeting and reduce damage to healthy tissue and organs. Stay on the edge of technology with new chapters on IGRT, DNA damage and repair, and molecularly targeted therapies.
Category: Medical

Stereotactic Body Radiation Therapy

Author : Simon S. Lo
ISBN : 9783642256059
Genre : Medical
File Size : 22.13 MB
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Stereotactic body radiation therapy (SBRT) has emerged as an important innovative treatment for various primary and metastatic cancers. This book provides a comprehensive and up-to-date account of the physical/technological, biological, and clinical aspects of SBRT. It will serve as a detailed resource for this rapidly developing treatment modality. The organ sites covered include lung, liver, spine, pancreas, prostate, adrenal, head and neck, and female reproductive tract. Retrospective studies and prospective clinical trials on SBRT for various organ sites from around the world are examined, and toxicities and normal tissue constraints are discussed. This book features unique insights from world-renowned experts in SBRT from North America, Asia, and Europe. It will be necessary reading for radiation oncologists, radiation oncology residents and fellows, medical physicists, medical physics residents, medical oncologists, surgical oncologists, and cancer scientists.
Category: Medical

Radiobiological Modelling In Radiation Oncology

Author : Roger G. Dale
ISBN : 9780905749600
Genre : Cancer
File Size : 65.93 MB
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The move towards individually-optimised treatments, using knowledge of normal tissue and tumour radiosensitivity, proliferation rates, etc, in combination with three-dimensional planning, will need mathematical modelling to achieve its full potential. This modelling process will also be capable of helping develop a rational and cost-effective use of resources.Amongst radiation oncologists and medical physicists there is a need for a greater understanding of the scope, applications and limitations of radiobiological modelling, particularly in complex situations that include multiple treatment variables, the respective influence of which are difficult to separate out by randomised trials without using radiobiologically-based analysis.In future there will be increasing use of modelling in practical situations, including treatment gap corrections, normal tissue tolerance predictions, optimisation of therapy determined by predictive assays, multi-modality schedule design, the simulation of clinical trials, testing contemporaneous medico-legal problems and teaching general principals of radiotherapy.
Category: Cancer