PROTEIN NMR SPECTROSCOPY PRINCIPLES AND PRACTICE

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Protein Nmr Spectroscopy

Author : John Cavanagh
ISBN : 008047103X
Genre : Science
File Size : 60.17 MB
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Protein NMR Spectroscopy, Second Edition combines a comprehensive theoretical treatment of NMR spectroscopy with an extensive exposition of the experimental techniques applicable to proteins and other biological macromolecules in solution. Beginning with simple theoretical models and experimental techniques, the book develops the complete repertoire of theoretical principles and experimental techniques necessary for understanding and implementing the most sophisticated NMR experiments. Important new techniques and applications of NMR spectroscopy have emerged since the first edition of this extremely successful book was published in 1996. This updated version includes new sections describing measurement and use of residual dipolar coupling constants for structure determination, TROSY and deuterium labeling for application to large macromolecules, and experimental techniques for characterizing conformational dynamics. In addition, the treatments of instrumentation and signal acquisition, field gradients, multidimensional spectroscopy, and structure calculation are updated and enhanced. The book is written as a graduate-level textbook and will be of interest to biochemists, chemists, biophysicists, and structural biologists who utilize NMR spectroscopy or wish to understand the latest developments in this field. Provides an understanding of the theoretical principles important for biological NMR spectroscopy Demonstrates how to implement, optimize and troubleshoot modern multi-dimensional NMR experiments Allows for the capability of designing effective experimental protocols for investigations of protein structures and dynamics Includes a comprehensive set of example NMR spectra of ubiquitin provides a reference for validation of experimental methods
Category: Science

Protein Nmr Spectroscopy

Author : Lu-Yun Lian
ISBN : 9781119972822
Genre : Science
File Size : 48.88 MB
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Nuclear Magnetic Resonance (NMR) spectroscopy, a physical phenomenon based upon the magnetic properties of certain atomic nuclei, has found a wide range of applications in life sciences over recent decades. The dramatic advances in NMR techniques have led to corresponding advances in the ability of NMR to study structure, dynamics and interactions of biological macromolecules in solution under close to physiological conditions. This volume focuses on the use of NMR to study proteins. NMR can be used to determine detailed three-dimensional structures of proteins in solution. Furthermore, it provides information about conformational or chemical exchange, internal mobility and dynamics at timescales varying from pcoseconds to seconds. It is the primary technique used to obtain information on intrinsically disordered (unfolded) proteins, since these proteins will not crystallize easily. NMR is also a very powerful method for the study of interactions of protein with other molecules, whether small molecules (including drugs), nuclear acids or other proteins. This up-to-date volume covers NMR techiniques and their application to proteins, with a focus on practical details. This book will provide a newcomer to NMR with the practical guidance in order to carry out successful experiments with proteins and to analyze the resulting spectra. Those who are familiar with the chemical applications of NMR will also find is useful in understanding the special requirements of protien NMR.
Category: Science

Nmr In Biological Systems

Author : K.V.R. Chary
ISBN : 9781402066795
Genre : Science
File Size : 59.51 MB
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During teaching NMR to students and researchers, we felt the need for a text-book which can cover modern trends in the application of NMR to biological systems. This book covers the entire area of NMR in Biological Sciences (Biomolecules, cells and tissues, animals, plants and drug design). As well as being useful to researchers, this is an excellent book for teaching a course on NMR in Biological Systems.
Category: Science

Annual Reports On Nmr Spectroscopy

Author : Graham A. Webb
ISBN : 9780123814340
Genre : Science
File Size : 44.17 MB
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Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy. * Provides updates on the latest developments in NMR spectroscopy * Includes comprehensive review articles * Highlights the increasing importance of NMR spectroscopy as a technique for structural determination
Category: Science

High Resolution Nmr Techniques In Organic Chemistry

Author : Timothy D. W. Claridge
ISBN : 0080427987
Genre : Science
File Size : 54.24 MB
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From the initial observation of proton magnetic resonance in water and in paraffin, the discipline of nuclear magnetic resonance has seen unparalleled growth as an analytical method. Modern NMR spectroscopy is a highly developed, yet still evolving, subject which finds application in chemistry, biology, medicine, materials science and geology. In this book, emphasis is on the more recently developed methods of solution-state NMR applicable to chemical research, which are chosen for their wide applicability and robustness. These have, in many cases, already become established techniques in NMR laboratories, in both academic and industrial establishments. A considerable amount of information and guidance is given on the implementation and execution of the techniques described in this book.
Category: Science

Pharmaceutical Biotechnology

Author : Gary Walsh
ISBN : 9781118685754
Genre : Science
File Size : 59.61 MB
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Pharmaceutical Biotechnology offers students taking Pharmacyand related Medical and Pharmaceutical courses a comprehensiveintroduction to the fast-moving area of biopharmaceuticals. With aparticular focus on the subject taken from a pharmaceuticalperspective, initial chapters offer a broad introduction to proteinscience and recombinant DNA technology- key areas that underpin thewhole subject. Subsequent chapters focus upon the development,production and analysis of these substances. Finally the book moveson to explore the science, biotechnology and medical applicationsof specific biotech products categories. These include not onlyprotein-based substances but also nucleic acid and cell-basedproducts. introduces essential principles underlining modernbiotechnology- recombinant DNA technology and protein science an invaluable introduction to this fast-moving subject aimedspecifically at pharmacy and medical students includes specific ‘product category chapters’focusing on the pharmaceutical, medical and therapeutic propertiesof numerous biopharmaceutical products. entire chapter devoted to the principles of genetic engineeringand how these drugs are developed. includes numerous relevant case studies to enhance studentunderstanding no prior knowledge of protein structure is assumed
Category: Science

Electron Paramagnetic Resonance

Author : Victor Chechik
ISBN : 9781788013727
Genre : Science
File Size : 55.4 MB
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Electron Paramagnetic Resonance (EPR) applications remain very significant in modern analytical science and this volume compiles critical coverage of developments in the recent literature by a handpicked group of researchers at the cutting-edge of the field. The topics covered in this volume describe contrasting types of EPR application, including light induced hyperpolarization and disordered proteins to spin labels and nanomaterials. Providing a snap shot of the area, this book is a useful addition to any library supporting this research.
Category: Science

Structure

Author :
ISBN : UCLA:L0098861479
Genre : Biomolecules
File Size : 54.2 MB
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Category: Biomolecules

Nmr Spectroscopy Data Acquisition

Author : Christian Schorn
ISBN : 3527288279
Genre : Science
File Size : 74.97 MB
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The key to correct structure analysis. This volume of the successful "Spectroscopic Techniques" series familiarizes newcomers with the basic data acquisition procedures, modular pulse sequence units and complete sequences in NMR spectroscopy. It applies the numerous possibilities of Bruker's simulation program NMR-SIM to provide a guided introduction to the world of pulse sequences. The effectiveness of particular NMR experiments is demonstrated by the section "Check Its" and that of data processing by the accompanying CD-ROM with the Bruker processing software 1D and 2D WIN-NMR. This interactive approach to simulate spectra based on a reduced spin system and the processing of the accomplished NMR raw data is closely related to everyday work at the spectrometer. In this way, the author encourages beginners to use high resolution NMR, and also experts on NMR spectroscopy to evaluate new experiments using the easy-manageable simulation program.
Category: Science