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Pharmacological Assays Of Plant Based Natural Products

Author : Parimelazhagan Thangaraj
ISBN : 9783319268118
Genre : Medical
File Size : 74.15 MB
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This volume provides information on how to select and screen plants for their medicinal properties. It describes phytopharmacological techniques for extracting and qualitatively and quantitatively analyzing a plant’s phytochemicals. After a detailed in vitro investigation including nutritional and anti-nutritional analyses, medicinal properties were tested with various in vivo models for anti-inflammatory, analgesic, anti-pyretic, anticancer and anti-diabetic properties, as well as wound healing, neurodegenerative diseases, etc. Compound identification and purification techniques include, among others, TLC and column chromatography, as well as molecular docking with specific proteins.
Category: Medical

Food Traceability And Authenticity

Author : Didier Montet
ISBN : 9781351230902
Genre : Science
File Size : 60.64 MB
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Food traceability is a growing consumer concern worldwide. Traceability is undertaken primarily at the administrative level, where the use of advanced analytical tools is not available. Nevertheless, the determination of geographical origin is a requirement of the traceability system for the import and export of foodstuffs (EU regulation 178/2002). The topics covered in this book include the history of traceability; legislations and rules; the actual traceability techniques and the potential analytical techniques for food traceability such as molecular methods (e.g. DGGE, SSCP), next generation sequencers (NGS), bio-captors, chromatographic techniques, isotopic analysis that are used for discrimination of organic food, fish, oils. The chromatographic techniques help in the use of volatile compounds analysis. The isotope analysis helps in distinguishing between chicken meat and vegetable oils. Ambient mass spectrometry is used for studying mycotoxines and alkaloids in foodstuffs and their management, food and feed authentication in olive and other plant oils, and wine. Vibrational methods (e.g. NMR and NIRS) are used to trace food by global spectrum. The book reviews the current and future techniques including metabolomic techniques.
Category: Science

Plant Bioactives And Drug Discovery

Author : Valdir Cechinel-Filho
ISBN : 9780470582268
Genre : Health & Fitness
File Size : 43.92 MB
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An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.
Category: Health & Fitness

Plant Derived Natural Products

Author : Anne E. Osbourn
ISBN : 0387854983
Genre : Science
File Size : 45.5 MB
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Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.
Category: Science

Cancer Drug Design And Discovery

Author : Stephen Neidle
ISBN : 9780123972286
Genre : Medical
File Size : 70.86 MB
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Cancer Drug Design and Discovery, Second Edition is an important reference on the underlying principles for the design and subsequent development of new anticancer small molecule agents. New chapters have been added to this edition on areas of particular interest and therapeutic promise, including cancer genomics and personalized medicine, DNA-targeted agents and more. This book includes several sections on the basic and applied science of cancer drug discovery and features those drugs that are now approved for human use and are in the marketplace, as well as those that are still under development. By highlighting some of the general principles involved in taking molecules through basic science to clinical development, this book offers a complete and authoritative reference on the design and discovery of anticancer drugs for translational scientists and clinicians involved in cancer research. Provides a clinical perspective on the development of new molecularly targeted anticancer agents with the latest and most promising chemotherapeutic approaches Offers a broad view of where the field is going, what tools drug discovery is using to produce new agents and how they are evaluated in the laboratory and clinic Features 6 new chapters devoted to advances in technology and successful anticancer therapies, such as cancer genomics and personalized medicine, DNA-targeted agents, B-Raf inhibitors and more Each chapter includes extensive references to the primary and review literature, as well as to relevant web-based sources
Category: Medical

Progress In Drug Research 50 1998

Author : Ernst Jucker
ISBN : 3764358211
Genre : Medical
File Size : 62.4 MB
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Progress in Drug Research is a prestigious book series (founded in 1959) which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmalogical research. Each volume contains fully cross-referencing indexes which link the volumes together, forming a virtually encyclopaedic work. The series thus serves as an important, time-saving source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines. Volume 50 in the series includes: P.N. Kaul: Drug discovery: Past, present and future M. Rohmer: Isoprenoid biosynthesis via the mevalonate -- independent route, a novel target for antibacterial drugs G. Edwards and A.H. Weston: Endothelium, -derived hyperpolarizing factor -- a critical appraisal R.W. Rockhold: Glutamatic involvement in psychomotor stimulant action J.M. Colacino and K.A. Staschke: The identification and development of antiviral agents for the treatment of chronic hepatitis B virus infection T.D. Johnson: Polyamines and cerebral ischemia
Category: Medical

Phytochemical Techniques

Author : N. Raaman
ISBN : 8189422308
Genre : Medical
File Size : 63.51 MB
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Phytochemicals are the individual chemicals from which the plants are made and plants are the key sources of raw material for both pharmaceutical and aromatic industries. the improved methods for higher yield of active compounds will be the major incentive in these industries. To help those who are involved in the isolation of compounds from plants, some of the essential phytochemical techniques are included in this book. The theoretical principles of various instruments, handling of samples and interpretation of spectra are given in detail. Adequate chemical formulas are included to support and explain various structures of compounds and techniques. The book will prove useful to students, researchers, professionals in the field of Plant Physiology and Pathology, Pharmaceutical and Chemical Engineering, Biotechnology, Medicinal and Aromatic Plants and Horticulture.
Category: Medical

Human Medicinal Agents From Plants

Author : A. Douglas Kinghorn
ISBN : 0841227055
Genre : Medical
File Size : 28.18 MB
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Covers the discovery, development, use and potential use, and regulation of plant-derived drugs. Describes ongoing research for prospective natural drugs with anticancer and anti-infective activities. Features some highly promising compounds, including artemisinin, camptothecin, forskolin, and taxol. Includes coverage of biologically active constituents of terrestrial and marine plants. Also addresses the effects of the destruction of rain forests on drug discovery.
Category: Medical