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Next Generation Antidepressants

Author : Chad E. Beyer
ISBN : 9780521760584
Genre : Medical
File Size : 62.2 MB
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The future of mood-disorder research: covering identification of new therapeutic targets, preclinical models, and medicinal chemistry opportunities.
Category: Medical

Annual Reports In Medicinal Chemistry

Author :
ISBN : 9780080583785
Genre : Science
File Size : 37.70 MB
Format : PDF, Docs
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Annual Reports in Medicinal Chemistry continues to strive to provide timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences which are expected to provide the basis for entirely new future therapies. Volume 34 retains the familiar format of previous volumes, this year with 33 chapters. Sections I-IV are disease-oriented and generally report on specific medicinal agents with updates from Volume 33 on antithrombotics, neurokinin receptor antagonists, anticoagualants, and new antibacterials. As in past volumes, annual updates have been limited to only the most active areas of research in favor of specifically focused and mechanistically oriented chapters, where the objective is to provide the reader with the most important new results in a particular field. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design as well as the critical interfaces among these disciplines. This volume concludes with To Market, To Market--a chapter on NCE and NBE introductions worldwide in 1998, a chapter on pharmagenomics, and finally one on malaria as a third world disease in need of a first world drug development.
Category: Science

Mood Disorders And Antidepressants

Author : Stephen M. Stahl
ISBN : 9781107729926
Genre : Medical
File Size : 31.76 MB
Format : PDF
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With the fully revised fourth edition of Essential Psychopharmacology, Dr Stahl returns to the essential roots of what it means to become a neurobiologically empowered psychopharmacologist, expertly guided in the selection and combination of treatments for individual patients in practice. This remains the essential text for all students and professionals in mental health seeking to understand and utilize current therapeutics, and to anticipate the future for novel medications. This special edition, featuring the extracted chapters on mood disorders and antidepressants, provides a readable digest on these specific issues for experts and novices alike.
Category: Medical

Contemporary Aspects Of Biomedical Research

Author :
ISBN : 0123786436
Genre : Medical
File Size : 23.45 MB
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Each volume of Advances in Pharmacology provides a rich collection of reviews on timely topics. Emphasis is placed on the molecular basis of drug action, both applied and experimental. Articles written by leading investigators in the field Informs and updates on all the latest developments
Category: Medical


Author : Allan Tasman
ISBN : 9781118753361
Genre : Medical
File Size : 26.95 MB
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Now in a new Fourth Edition, Psychiatry remains the leading reference on all aspects of the current practice and latest developments in psychiatry. From an international team of recognised expert editors and contributors, Psychiatry provides a truly comprehensive overview of the entire field of psychiatry in 132 chapters across two volumes. It includes two new sections, on psychosomatic medicine and collaborative care, and on emergency psychiatry, and compares Diagnostic and Statistical Manual (DSM-5) and International Classification of Diseases (ICD10) classifications for every psychiatric disorder. Psychiatry, Fourth Edition is an essential reference for psychiatrists in clinical practice and clinical research, residents in training, and for all those involved in the treatment psychiatric disorders. Includes a a companion website at featuring PDFs of each chapter and downloadable images
Category: Medical

Frontiers In Drug Discovery

Author : João Quevedo
ISBN : 9781681084732
Genre : Medical
File Size : 46.40 MB
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Major depressive disorder (MDD) is a prevalent, chronic, and recurring mental disorder. This disorder is a leading source of disability worldwide, and is associated with excess mortality rates. Currently approved antidepressants primarily enhance, or otherwise modulate monoaminergic neurotransmission, without curing the disease. Evidence indicates that only one third of patients with MDD achieve remission after treatment with a first-line antidepressant agent. Research in the past two decades has provided valuable insights into the pathophysiological understanding of MDD. However, there is an acknowledged ‘translational gap’ in the field, and few genuinely novel antidepressants have been approved for the treatment of MDD. The Search for Anti Depressants provides readers an in-depth picture of the main pathophysiological mechanisms responsible for the development of MDD in patients. Chapters in the volume focus on possible strategies to spur the discovery of novel antidepressants. This book is an indispensable reference for mental health care providers, students at both under-graduate and graduate levels, and neuroscientists interested in the neurobiology of MDD and recent advances towards the discovery of next generation antidepressants.
Category: Medical

Clinical Trials Of Antidepressants

Author : Martin M. Katz
ISBN : 9783319264646
Genre : Psychology
File Size : 49.25 MB
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This brief guide takes current clinical trial protocols to task and replaces them with a contemporary framework for improving next-generation antidepressants and their underlying science. Innovative models are based on a nuanced, neurologically-informed understanding of drug mechanisms and the component cognitive, mood, and behavioral aspects of depression. The book reconceptualizes not only the clinical trial process but the clinical concept of depression itself as essential to bringing pharmaceutical research and development up to date, boosting efficiency and effectiveness, finding new molecules, and reducing waste. Case studies and a review of salient depression scales illustrate the potential benefits of such wide-scale change. Included in the coverage: Why now the need for a new clinical trials model for antidepressants? Aims and basic requirements of clinical trials: conventional and component-specific models. Methods for measuring the components and the profile of drug actions: the multivantaged approach. Achieving the ideal clinical trial: an example of the merged componential and established models. Prediction and shortening the clinical trial. The video clinical trial. Clinical Trials of Antidepressants will interest a varied audience, including clinical investigators, academic and pharmaceutical company scientists, clinical trial organizations, psychiatrists, outpatient physicians, psychotherapists, clinical psychologists, psychology graduate students, medical students, and government agencies such as the FDA.
Category: Psychology

Challenges And Opportunities Of Next Generation Sequencing For Biomedical Research

Author : Mark I. Rees
ISBN : 9780123942876
Genre : Science
File Size : 68.66 MB
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Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Challenges and Opportunities of Next-Generation Sequencing for Biomedical Research. Covers reviews of methodology and research in all aspects of protein chemistry Brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics
Category: Science

The Feel Good Factor

Author : Patrick Holford
ISBN : 9780748118670
Genre : Health & Fitness
File Size : 69.25 MB
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Low mood, motivation and depression are endemic, and on the increase. About 40% of all GP visits are for people feeling depressed. In America recent figures show that one in ten have been prescribed anti-depressants. The recession has fuelled the need for the feel good factor. This book, written by leading nutrition expert and psychologist delivers highly effective ways - nutritional and psychological, with practical lifestyle and life management techniques - that really make a difference to how you feel. If you eat the right foods, avoid the wrong ones, your mood will improve dramaticaly - and quickly. Patrick Holford's approach is supported by substantial research, and backed up by poignant and motivating case histories. It also includes case histories of those at the suicidal end of depression who failed to get better with conventional approaches, and recovered completely on Holford's regime. The book would be supported by further in-depth analysis relating to mood and diet taken from Holford's 100% Health survey which was completed by over 55,000 people..
Category: Health & Fitness

Thin Layer Chromatography In Drug Analysis

Author : Lukasz Komsta
ISBN : 9781466507166
Genre : Medical
File Size : 35.67 MB
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Used routinely in drug control laboratories, forensic laboratories, and as a research tool, thin layer chromatography (TLC) plays an important role in pharmaceutical drug analyses. It requires less complicated or expensive equipment than other techniques, and has the ability to be performed under field conditions. Filling the need for an up-to-date, complete reference, Thin Layer Chromatography in Drug Analysis covers the most important methods in pharmaceutical applications of TLC, namely, analysis of bulk drug material and pharmaceutical formulations, degradation studies, analysis of biological samples, optimization of the separation of drug classes, and lipophilicity estimation. The book is divided into two parts. Part I is devoted to general topics related to TLC in the context of drug analysis, including the chemical basis of TLC, sample pleparation, the optimization of layers and mobile phases, detection and quantification, analysis of ionic compounds, and separation and analysis of chiral substances. The text addresses the newest advances in TLC instrumentation, two-dimensional TLC, quantification by slit scanning densitometry and image analysis, statistical processing of data, and various detection and identification methods. It also describes the use of TLC for solving a key issue in the drug market—the presence of substandard and counterfeit pharmaceutical products. Part II provides an in-depth overview of a wide range of TLC applications for separation and analysis of particular drug groups. Each chapter contains an introduction about the structures and medicinal actions of the described substances and a literature review of their TLC analysis. A useful resource for chromatographers, pharmacists, analytical chemists, students, and R&D, clinical, and forensic laboratories, this book can be utilized as a manual, reference, and teaching source.
Category: Medical