MOLECULAR ASPECTS OF BIOELECTRICITY

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Molecular Aspects Of Bioelectricity

Author : Ernest Schoffeniels
ISBN : 9781483189857
Genre : Nature
File Size : 22.41 MB
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Molecular Aspects of Bioelectricity describes the self-organization in molecular and cellular networks. This book evaluates the chemical representation of ion flux gating in excitable biomembranes and addresses the theoretical implication of liganding reactions in axonal sodium channel gating. It also strongly demonstrates the ligand interactions of crustacean axonal membrane. The opening chapters deal with the biochemical studies of the structure, mechanism, and differentiation of the voltage-sensitive sodium channel; and biochemical cycle of impedance variation in axonal membranes. The succeeding chapters examine the effect of various compounds on the phosphorylation of nerve proteins and the molecular aspects of the actions of cyclic nucleotides at synapses. These topics are followed by discussions of the acetylcholine and choline acetyltransferase, as well as the polymorphism of cholinesterase in vertebrates. The closing chapters are devoted to the physical factors determining gated flux from and into sealed membrane fragments. The book can provide useful information to biologists, students, and researchers.
Category: Nature

Chemical And Molecular Basis Of Nerve Activity

Author : David Nachmansohn
ISBN : 9780323151023
Genre : Medical
File Size : 42.25 MB
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Chemical and Molecular Basis of Nerve Activity contains 16 chapters that discuss the significant advances in the study of the molecular events underlying bioelectricity and nerve excitability. After briefly describing the physiology and mechanisms of the nervous system, this book goes on examining the physiologically significant features and nerve activity roles of acetylcholines and acetylcholinesterase. A chapter highlights the mechanism of acetylcholinerase inhibition by nerve gases and insecticides. Other chapters explore the characteristic properties of choline acetylase enzyme; the relationships between chemical forces and electrical activity; and the effect of acetylcholine and analog compounds on the isolation of receptor protein and on synaptic junctions. The remaining chapters deal with the essential role of acetylcholine in the generation of bioelectric current and the differences between axonal conduction and synaptic transmission. The supplementary texts look into the progress in the biochemistry of excitability and present an integral model of nerve excitability. This book will be of great benefit to biologists and neurologists.
Category: Medical

Bioimpedance And Bioelectricity Basics

Author : Sverre Grimnes
ISBN : 9780124115330
Genre : Technology & Engineering
File Size : 90.98 MB
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Bioimpedance and Bioelectricity Basics, 3rd Edition paves an easier and more efficient way for people seeking basic knowledge about this discipline. This book's focus is on systems with galvanic contact with tissue, with specific detail on the geometry of the measuring system. Both authors are internationally recognized experts in the field. The highly effective, easily followed organization of the second edition has been retained, with a new discussion of state-of-the-art advances in data analysis, modelling, endogenic sources, tissue electrical properties, electrodes, instrumentation and measurements. This book provides the basic knowledge of electrochemistry, electronic engineering, physics, physiology, mathematics, and model thinking that is needed to understand this key area in biomedicine and biophysics. Covers tissue immittance from the ground up in an intuitive manner, supported with figures and examples New chapters on electrodes and statistical analysis Discusses in detail dielectric and electrochemical aspects, geometry and instrumentation as well as electrical engineering concepts of network theory, providing a cross-disciplinary resource for engineers, life scientists, and physicists
Category: Technology & Engineering

The Physiology Of Bioelectricity In Development Tissue Regeneration And Cancer

Author : Christine E. Pullar
ISBN : 1439837244
Genre : Medical
File Size : 70.83 MB
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Recent advances in technology have led to the unprecedented accuracy in measurements of endogenous electric fields around sites of tissue disruption. State-of-the-art molecular approaches demonstrate the role of bioelectricity in the directionality and speed of cell migration, proliferation, apoptosis, differentiation, and orientation. New information indicates that electric fields play a role in initiating and coordinating complex regenerative responses in development and wound repair and that they may also have a part in cancer progression and metastasis. Compiling current research in this rapidly expanding field, Physiology of Bioelectricity in Development, Tissue Regeneration, and Cancer highlights relevant, cutting-edge topics poised to drive the next generation of medical breakthroughs. Chapters consider methods for detecting endogenous electric field gradients and studying applied electric fields in the lab. The book addresses bioelectricity’s roles in guiding cell behavior during morphogenesis and orchestrating higher order patterning. It also covers the response of stem cells to applied electric fields, which reveals bioelectricity as an exciting new player in tissue engineering and regenerative medicine. This book provides an in-depth exploration of how electric signals control corneal wound repair and skin re-epithelialization, angiogenesis, and inflammation. It also delves into the bioelectric responses of cells derived from the musculoskeletal system, bioelectrical guidance of neurons, and the beneficial application of voltage gradients to promote regeneration in the spinal cord. It concludes with a discussion of bioelectricity and cancer progression and the potential for novel cancer biomarkers, new methods for early detection, and bioelectricity-based therapies to target both the tumor and metastatic cancer cells. This multidisciplinary compilation will benefit biologists, biochemists, biomedical scientists, engineers, dermatologists, and clinicians, or anyone else interested in development, regeneration, cancer, and tissue engineering. It can also serve as an ideal textbook for students in biology, medicine, medical physiology, biophysics, and biomedical engineering.
Category: Medical

Bioelectricity

Author : Robert Plonsey
ISBN : 9781475731521
Genre : Technology & Engineering
File Size : 78.95 MB
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In the first edition of Bioelectricity, Plonsey and Barr provided an introduction to electrophysiology following a quantitative approach. In this second edition they address new discoveries in the field of ion channels. The text is an introduction to electrophysiology utilizing a quantitative approach. It describes the principles of electrical fields, using basic principles from science and engineering while taking the biological applications into consideration. The book thus provides an introduction to the quantitative description of underlying electrophysiology with illustrative application to cardiac electrophysiology and functional electrical stimulation. The book can be used as a bridge to more advanced texts, particularly those that stress a quantitative approach.
Category: Technology & Engineering

Modern Bioelectricity

Author : Andrew A. Marino
ISBN : 0824777883
Genre : Technology & Engineering
File Size : 49.83 MB
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Category: Technology & Engineering

Molecular Basis And Thermodynamics Of Bioelectrogenesis

Author : E. Schoffeniels
ISBN : 9789400921436
Genre : Science
File Size : 59.50 MB
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Despite the fact that many years have elapsed since the first microcalorimetric measurements of an action potential were made, there is still among the research workers involved in the study of bioelectrogenesis a complete overlooking of the most fundamental principle governing any biological phenomenon at the molecular scale of dimension. This is surprising, the more so that the techniques of molecular biology are applied to characterize the proteins forming the ionic conducting sites in living membranes. For reasons that are still obscure to us the molecular aspects of bioelectrogenesis are completely out of the scope of the dynamic aspects of biochemistry. Even if it is sometimes recognized that an action potential is a free energy-consuming, entropy-producing process, the next question that should reasonably arise is never taken into consideration. There is indeed a complete evasion of the problem of biochemical energy coupling thus reducing the bioelectrogenesis to only physical interactions of membrane proteins with the electric field: the inbuilt postulate is that no molecular transformations, in the chemical sense, could be involved.
Category: Science

Bioimpedance And Bioelectricity Basics

Author : Sverre Grimnes
ISBN : 0123032601
Genre : Science
File Size : 73.64 MB
Format : PDF
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Bioimpedance and Bioelectricity Basics is unique in providing all the information needed to follow the interdisciplinary subjects of bioimpedance and bioelectricity without having to be a graduate student in the relevant fields. For the first time, one book offers the broadest possible introduction to all use and effects of electrical fields in tissue, dealing with the most basic chemical and physical functions of life. Very few books have covered the dielectric and electrochemical side of the subject, despite its importance; Bioimpedance and Bioelectricity Basics does. It also includes the electrical engineering concepts of network theory and the complex math needed. Up to now, there has been work done by physicists and engineers on one side, doctors and biologists on the other, this book fills the gap, providing the knowledge for both groups. Key Features * is one complete source and reference guide to a complex and disparate field * gives the reader the latest research and applications * is highly illustrated, with an indepth explanation of all mathematics
Category: Science

The Physiology Of Bioelectricity In Development Tissue Regeneration And Cancer

Author : Christine E. Pullar
ISBN : 1439837244
Genre : Medical
File Size : 26.16 MB
Format : PDF, Docs
Download : 271
Read : 1245

Recent advances in technology have led to the unprecedented accuracy in measurements of endogenous electric fields around sites of tissue disruption. State-of-the-art molecular approaches demonstrate the role of bioelectricity in the directionality and speed of cell migration, proliferation, apoptosis, differentiation, and orientation. New information indicates that electric fields play a role in initiating and coordinating complex regenerative responses in development and wound repair and that they may also have a part in cancer progression and metastasis. Compiling current research in this rapidly expanding field, Physiology of Bioelectricity in Development, Tissue Regeneration, and Cancer highlights relevant, cutting-edge topics poised to drive the next generation of medical breakthroughs. Chapters consider methods for detecting endogenous electric field gradients and studying applied electric fields in the lab. The book addresses bioelectricity’s roles in guiding cell behavior during morphogenesis and orchestrating higher order patterning. It also covers the response of stem cells to applied electric fields, which reveals bioelectricity as an exciting new player in tissue engineering and regenerative medicine. This book provides an in-depth exploration of how electric signals control corneal wound repair and skin re-epithelialization, angiogenesis, and inflammation. It also delves into the bioelectric responses of cells derived from the musculoskeletal system, bioelectrical guidance of neurons, and the beneficial application of voltage gradients to promote regeneration in the spinal cord. It concludes with a discussion of bioelectricity and cancer progression and the potential for novel cancer biomarkers, new methods for early detection, and bioelectricity-based therapies to target both the tumor and metastatic cancer cells. This multidisciplinary compilation will benefit biologists, biochemists, biomedical scientists, engineers, dermatologists, and clinicians, or anyone else interested in development, regeneration, cancer, and tissue engineering. It can also serve as an ideal textbook for students in biology, medicine, medical physiology, biophysics, and biomedical engineering.
Category: Medical

Electrical Potentials In Biological Membrane Transport

Author : E. Heinz
ISBN : 9783642816758
Genre : Science
File Size : 61.76 MB
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The material of this volume was originally planned to be incorporated in the preceding monograph Mechanics and Energetics of Biological Transport. A separate and coherent treatment ofthe variety of bioelectrical phenomena was considered preferable, mainly for didactic reasons. Usually, the biologist has to gather the principles of bioelectricity he needs from different sources and on different levels. The present book intends to provide these principles in a more uniform context and in a form adjusted to the problems of a biol ogist, rather than of a physicist or electrical engineer. The main emphasis is put on the molecular aspect by relating the bioelectrical phenomena, such as the membrane diffusion potentials, pump potentials, or redox potentials, to the properties of the membrane concerned, and, as far as pOSSible, to specific steps of transport and metabolism of ions and nonelectrolytes. Little space is devoted to the familiar and widely used representation of bioelectrical phe nomena in terms of electrical networks, of equivalent circuits with batteries, resistances, capacities etc. In order to elucidate the basic principles, the formal treatment is kept as simple as pOSSible, using highly Simplified models, based on biological systems. The corresponding equations are derived in two ways: kinetically, i. e. in terms of the Law of Mass Action, as well as energetically, i. e. , in terms of Nonequilibrium Thermodynamics.
Category: Science