MODELLING METABOLISM WITH MATHEMATICA

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Modelling Metabolism With Mathematica

Author : Peter Mulquiney
ISBN : 9780203503935
Genre : Science
File Size : 20.61 MB
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With the advent of sophisticated general programming environments like Mathematica, the task of developing new models of metabolism and visualizing their responses has become accessible to students of biochemistry and the life sciences in general. Modelling Metabolism with Mathematica presents the approaches, methods, tools, and algorithms for modelling the chemical-dynamics of metabolic pathways. The authors explain the concepts underpinning the deterministic theory of chemical and enzyme kinetics, present a graded series of computer models of metabolic pathways leading up to that of the human erythrocyte, and document a consistent set of rate equations and associated kinetic parameters. The experimental and theoretical study of metabolism in mammalian cells has a long and fruitful history, but our understanding of cellular metabolism at the molecular level is far from complete. This book enables its readers to formulate their own models of time-dependent metabolic systems and aids them in the quest for the many fundamental and clinically relevant discoveries that remain to be made.
Category: Science

Bioengineering And Molecular Biology Of Plant Pathways

Author :
ISBN : 0080556965
Genre : Science
File Size : 30.72 MB
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The increased knowledge about the structure of genomes in a number of species, about the complexity of transcriptomes, and the rapid growth in knowledge about mutant phenotypes have set off the large scale use of transgenes to answer basic biological questions, and to generate new crops and novel products. Bioengineering and Molecular Biology of Plant Pathways includes twelve chapters, which to variable degrees describe the use of transgenic plants to explore possibilities and approaches for the modification of plant metabolism, adaptation or development. The interests of the authors range from tool development, to basic biochemical know-how about the engineering of enzymes, to exploring avenues for the modification of complex multigenic pathways, and include several examples for the engineering of specific pathways in different organs and developmental stages. Prologue by Paul K. Stumpf and Eric E. Conn Incorporates new concepts and insights in plant biochemistry and biology Provides a conceptual framework regarding the challenges faced in engineering pathways Discusses potential in engineering of metabolic end-products that are of vast economical importance, including genetic engineering of cellulose, seed storage proteins, and edible and industrial oils
Category: Science

Nostradamus 2013 Prediction Modeling And Analysis Of Complex Systems

Author : Ivan Zelinka
ISBN : 9783319005423
Genre : Computers
File Size : 26.5 MB
Format : PDF
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Prediction of behavior of the dynamical systems, analysis and modeling of its structure is vitally important problem in engineering, economy and science today. Examples of such systems can be seen in the world around us and of course in almost every scientific discipline including such “exotic” domains like the earth’s atmosphere, turbulent fluids, economies (exchange rate and stock markets), population growth, physics (control of plasma), information flow in social networks and its dynamics, chemistry and complex networks. To understand such dynamics and to use it in research or industrial applications, it is important to create its models. For this purpose there is rich spectra of methods, from classical like ARMA models or Box Jenkins method to such modern ones like evolutionary computation, neural networks, fuzzy logic, fractal geometry, deterministic chaos and more. This proceeding book is a collection of the accepted papers to conference Nostradamus that has been held in Ostrava, Czech Republic. Proceeding also comprises of outstanding keynote speeches by distinguished guest speakers: Guanrong Chen (Hong Kong), Miguel A. F. Sanjuan (Spain), Gennady Leonov and Nikolay Kuznetsov (Russia), Petr Škoda (Czech Republic). The main aim of the conference is to create periodical possibility for students, academics and researchers to exchange their ideas and novel methods. This conference will establish forum for presentation and discussion of recent trends in the area of applications of various predictive methods for researchers, students and academics.
Category: Computers

Enzyme Kinetics

Author : Robert A. Alberty
ISBN : 1118002156
Genre : Science
File Size : 65.63 MB
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Rapid-Equilibrium Enzyme Kinetics helps readers emphasize the estimation of kinetic parameters with the minimum number of velocity measurements, thereby reducing the amount of laboratory work necessary, and allowing more time for the consideration of complicated mechanisms. The book systematically progresses through six levels of understanding the enzyme-catalyzed reaction, and includes a CD-ROM so that the reader may use the programs in the book to input their own experimental data.
Category: Science

Mathematical Modeling In Systems Biology

Author : Brian P. Ingalls
ISBN : 9780262315647
Genre : Science
File Size : 50.25 MB
Format : PDF
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Systems techniques are integral to current research in molecular cell biology, and system-level investigations are often accompanied by mathematical models. These models serve as working hypotheses: they help us to understand and predict the behavior of complex systems. This book offers an introduction to mathematical concepts and techniques needed for the construction and interpretation of models in molecular systems biology. It is accessible to upper-level undergraduate or graduate students in life science or engineering who have some familiarity with calculus, and will be a useful reference for researchers at all levels.The first four chapters cover the basics of mathematical modeling in molecular systems biology. The last four chapters address specific biological domains, treating modeling of metabolic networks, of signal transduction pathways, of gene regulatory networks, and of electrophysiology and neuronal action potentials. Chapters 3--8 end with optional sections that address more specialized modeling topics. Exercises, solvable with pen-and-paper calculations, appear throughout the text to encourage interaction with the mathematical techniques. More involved end-of-chapter problem sets require computational software. Appendixes provide a review of basic concepts of molecular biology, additional mathematical background material, and tutorials for two computational software packages (XPPAUT and MATLAB) that can be used for model simulation and analysis.
Category: Science

Enzyme Kinetics Catalysis And Control

Author : Daniel L. Purich
ISBN : 9780123809254
Genre : Science
File Size : 52.84 MB
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Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions
Category: Science

Structured Biological Modelling

Author : Michael Kraus
ISBN : 0849347726
Genre : Science
File Size : 59.36 MB
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Structured Biological Modelling presents a straightforward introduction for computer-aided analysis, mathematical modelling, and simulation of cell biological systems. This unique guide brings together the physiological, structural, molecular biological, and theoretical aspects of the signal transduction network that regulates growth and proliferation in normal and tumor cells. It provides comprehensive survey of functional and theoretical features of intracellular signal processing and introduces the concept of cellular self-organization. Exemplified by oscillatory calcium waves, strategies for the design of computer experiments are presented that can assist or even substitute for time-consuming biological experiments. The presented minimal model for proliferation-associated signal transduction clearly shows the alterations of the cellular signal network involved in neoplastic growth. This book will be useful to cell and molecular biologists, oncologists, physiologists, theoretical biologists, computer scientists, and all other researchers and students studying functional aspects of cellular signaling.
Category: Science

The Evolution Of Metabolic Function

Author : Robert P. Mortlock
ISBN : 0849388635
Genre : Medical
File Size : 34.66 MB
Format : PDF
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The Evolution of Metabolic Function presents comprehensive discussions on a variety of topics that will interest scientists and students studying the evolution of enzyme activities, the evolution of enzymatic pathways, and the evolution and development of metabolic functions. Laboratory experiments designed to develop new enzyme activities and new metabolic pathways are discussed. The most recent techniques comparing protein and gene structures are used to analyze and discuss the evolution and development of such metabolic functions as the bacterial phosphoenolpyruvate:sugar phosphotransferase system, the mandelate pathway of microorganisms, bacterial alcohol metabolism, and certain microbial amino acid biosynthetic pathways. The book also includes some unique speculations regarding the origin of early Archaean cells and the prebiotic evolution of complex molecules.
Category: Medical

Who S Who In Australia

Author : Suzannah Pearce
ISBN : 1740951301
Genre : Australia
File Size : 66.21 MB
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Category: Australia