IRON OXIDE NANOPARTICLES FOR BIOMEDICAL APPLICATIONS

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Iron Oxide Nanoparticles For Biomedical Applications

Author : Sophie Laurent
ISBN : 9780081012758
Genre : Technology & Engineering
File Size : 76.68 MB
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Iron Oxide Nanoparticles for Biomedical Applications: Synthesis, Functionalization and Application begins with several chapters covering the synthesis, stabilization, physico-chemical characterization and functionalization of iron oxide nanoparticles. The second part of the book outlines the various biomedical imaging applications that currently take advantage of the magnetic properties of iron oxide nanoparticles. Brief attention is given to potential iron oxide based therapies, while the final chapter covers nanocytotoxicity, which is a key concern wherever exposure to nanomaterials might occur. This comprehensive book is an essential reference for all those academics and professionals who require thorough knowledge of recent and future developments in the role of iron oxide nanoparticles in biomedicine. Unlocks the potential of iron oxide nanoparticles to transform diagnostic imaging techniques Contains full coverage of new developments and recent research, making this essential reading for researchers and engineers alike Explains the synthesis, processing and characterization of iron oxide nanoparticles with a view to their use in biomedicine
Category: Technology & Engineering

Nanobiomaterials

Author : Xiu-Mei Wang
ISBN : 9783527698639
Genre : Technology & Engineering
File Size : 65.10 MB
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Read : 388

Written by an international team of editors and contributors from renowned universities and institutes, this book addresses the latest research in the field of nanobiomaterials, covering nanotechnologies for their fabrication, developments in biomedical applications, and the challenges of biosafety in clinic uses. Clearly structured, the volume defines the scope and classification of the field, resulting in a broad overview from fundamental principles to current technological advances, and from materials synthesis to biomedical applications along with future trends.
Category: Technology & Engineering

Superparamagnetic Iron Oxide Nanoparticles

Author : Morteza Mahmoudi
ISBN : 1616689641
Genre : Technology & Engineering
File Size : 21.11 MB
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In recent years, the fabrication of nanoparticles and exploration of their properties have attracted the attention of physicists, chemists, biologists and engineers. Interest in nanoparticles arise from the fact that the mechanical, chemical, electrical, optical, magnetic, electro-optical and magneto-optical properties of these particles are different from their bulk properties and depend on the particle size. There are numerous areas where nanoparticulate systems are of scientific and technological interest. This book reviews research on the various components of superparamagnetic iron oxide nanoparticles.
Category: Technology & Engineering

Multifunctional Iron Oxide Nanoparticles For Biomedical Applications

Author : Yaolin Xu
ISBN : OCLC:895198806
Genre : Electronic dissertations
File Size : 32.66 MB
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This dissertation focuses on the preparation of multifunctional nanoparticles through the integration of iron oxide nanoparticles with other desired moieties. Iron oxide nanoparticles have been widely explored in localized therapy, targeted delivery, and magnetic resonance imaging. However, inaccessible MRI instruments for most research labs and lack of targeting ligands limits the further exploration of iron oxide nanoparticles in routine tumor diagnosis and efficient therapy. Therefore, the preparation of dual-imaging or targeted nanoparticles is highly desirable. In our studies, fluorescent gold nanoclusters or anti & ndashdisialoganglioside & ndashGD2 monoclonal antibodies are integrated onto iron oxide nanoparticle surfaces. The gold nanoclusters provide additional fluorescent imaging capability, which can be easily accessed in common research labs. The conjugation of cancer cell & ndashtargeting antibodies allows for specific localization of nanoparticles. Indeed, these are the two central themes of this dissertation. To prepare multifunctional nanoparticles, high & ndashquality iron oxide nanoparticles were first synthesized in organic solvents following a modified & ldquoheat & ndashup & rdquo method. During synthesis, a modification was made by introducing a co & ndashsurfactant (trioctylphosphine oxide & ndashTOPO). TOPO facilitated the subsequent ligand exchange process because it weakly bound to nanoparticle surfaces and prevented the formation of densely & ndashpacked surfactant coatings. As a result, hydrophilic molecules (such as polyacrylic acid, polyethylenimine, glutathione and dopamine) were capable of replacing the original ligands, yielding water & ndashsoluble iron oxide nanoparticles. In addition to water solubility, dopamine coatings offered nanoparticles additional conjugation capability upon surface oxidization. These surface & ndashoxidized nanoparticles can directly conjugate with amine and/or thiol group & ndashcontained molecules through Michael addition and/or Schiff base formation. Using this conjugation strategy, dual & ndashimaging nanoparticles were prepared by integrating dopamine & ndashcoated nanoparticles with protein (such as bovine serum albumin, trypsin and lysozyme) & ndash encapsulated fluorescent gold nanoclusters. All integrated nanoparticles maintained their functionalities and structural integrity in biological environments. Furthermore, effects of protein characteristics on the photo & ndashchemical properties of gold nanoclusters and integrated nanoparticles were systematically examined. Similarly, cancer cell & ndashtargeting molecules (e.g. anti & ndashGD2 monoclonal antibodies) were conjugated onto dopamine & ndashcoated nanoparticles. After conjugation, antibodies retained their high targeting specificity, suggested by our cellular targeting studies. More promisingly, conjugated nanoparticles were capable of transporting into cytosols, which opens up new possibilities in cancer & ndashcuring drug loading and targeted therapy. Besides these already & ndashpublished works, we have studied the biological responses of human monocytes to different surface & ndashcharged iron oxide nanoparticles (manuscript in preparation). For dual & ndashimaging nanoparticles, their stability and bio & ndashimaging potential will be evaluated in phorbol myristate acetate (PMA) & ndashtreated monocytes using differential interference contrast (DIC) and confocal microscopy.
Category: Electronic dissertations

Clinical Applications Of Magnetic Nanoparticles

Author : Nguyen TK Thanh
ISBN : 9781351685429
Genre : Medical
File Size : 59.82 MB
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Offering the latest information in magnetic nanoparticle (MNP) research, this book builds upon the success of the first volume and provides an updated and comprehensive review, from synthesis, characterization, and biofunctionalization to clinical applications of MNPs, including the diagnosis and treatment of cancers. The book captures some of emerging research area which was not available in the first volume. Good Manufacturing Practices and Commercialization of MNPs are also included. This volume, also written by some of the most qualified experts in the field, incorporates new developments in the literature, and continues to bridge the gaps between the different areas in this field.
Category: Medical

Metal Nanoparticles In Pharma

Author : Mahendra Rai, Ph.D
ISBN : 9783319637907
Genre : Medical
File Size : 86.99 MB
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Completely dedicated to the biomedical applications of metal nanoparticles, this book covers the different toxicity problems found in healthcare situations and also provides comprehensive info on the use of metal nanoparticles in treating various diseases. Metal Nanoparticles in Pharma is the first edited volume to set up the discussion for a clinical setting and to target a pharmaceutical audience of academic and industry-based researchers.
Category: Medical

5th International Conference On Biomedical Engineering In Vietnam

Author : Vo Van Toi
ISBN : 9783319117768
Genre : Technology & Engineering
File Size : 56.80 MB
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This volume presents the proceedings of the Fifth International Conference on the Development of Biomedical Engineering in Vietnam which was held from June 16-18, 2014 in Ho Chi Minh City. The volume reflects the progress of Biomedical Engineering and discusses problems and solutions. I aims identifying new challenges, and shaping future directions for research in biomedical engineering fields including medical instrumentation, bioinformatics, biomechanics, medical imaging, drug delivery therapy, regenerative medicine and entrepreneurship in medical devices.
Category: Technology & Engineering

Nanotoxicology

Author : Alok Dhawan
ISBN : 9781782621584
Genre :
File Size : 78.95 MB
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Category:

Magnetic Nanoparticles

Author : Nguyen TK Thanh
ISBN : 9781439869338
Genre : Science
File Size : 77.88 MB
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Offering the latest information in magnetic nanoparticle (MNP) research, Magnetic Nanoparticles: From Fabrication to Clinical Applications provides a comprehensive review, from synthesis, characterization, and biofunctionalization to clinical applications of MNPs, including the diagnosis and treatment of cancers. This book, written by some of the most qualified experts in the field, not only fills a hole in the literature, but also bridges the gaps between all the different areas in this field. Translational research on tailored magnetic nanoparticles for biomedical applications spans a variety of disciplines, and putting together the most significant advances into a practical format is a challenging task. Balancing clinical applications with the underlying theory and foundational science behind these new discoveries, Magnetic Nanoparticles: From Fabrication to Clinical Applications supplies a toolbox of solutions and ideas for scientists in the field and for young researchers interested in magnetic nanoparticles.
Category: Science