INTRODUCTION TO BIOMOLECULAR ENERGETICS INCLUDING LIGAND RECEPTOR INTERACTIONS

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Introduction To Biomolecular Energetics

Author : Irving Klotz
ISBN : 9780323160995
Genre : Science
File Size : 69.86 MB
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Introduction to Biomolecular Energetics Including Ligand-Receptor Interactions focuses on the concepts of energetics and their biological applications, including the study of ligand-receptor interactions. The book provides quantitative calculations and addresses topics that have become more prominent in the biochemical and related sciences in recent years, including the first and second laws of thermodynamics, the concept of entropy, free energy or chemical potential, group-transfer potential, physicochemical behavior, and enzyme kinetics. This volume is organized into 10 chapters, and it begins with an overview of the scope of energetics and two general approaches to the field: the classical or phenomenological approach and the statistical-molecular approach. The chapters that follow explore the concepts of energy and entropy in the context of the first and second laws of thermodynamics, along with the relationships between work, heat, energy and entropy as an index of exhaustion. The discussion then shifts to the free energy function and general procedures for computing standard free energies. The book also introduces the reader to the fundamental relationship between chemical potential (free energy) and concentration; high-energy bond and the concept of group-transfer potential; the use of thermodynamic methods in the analysis of physicochemical behavior; and statistical thermodynamics. The final chapter examines the number of ligands that are bound by the receptor entity, how strongly the ligands are held, and the molecular nature of the forces of ligand-receptor interaction. This book will be of interest to biologists and those who want to understand the principles of energetics governing biochemical changes.
Category: Science

Enzyme Kinetics

Author : Hans Bisswanger
ISBN : 9783527806478
Genre : Science
File Size : 21.32 MB
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Now in full color for a more intuitive learning experience, this new edition of the long-selling reference also features a number of new developments in methodology and the application of enzyme kinetics. Starting with a description of ligand binding equilibria, the experienced author goes on to discuss simple and complex enzyme reactions in kinetic terms. Special cases such as membrane-bound and immobilized enzymes are considered, as is the influence of external conditions, such as temperature and pH value. The final part of the book then covers a range of widely used measurement methods and compares their performance and scope of application. With its unique mix of theory and practical advice, this is an invaluable aid for teaching as well as for experimental work.
Category: Science

Protein Ligand Interactions

Author : Hans-Joachim Böhm
ISBN : 9783527605514
Genre : Science
File Size : 84.13 MB
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The lock-and-key principle formulated by Emil Fischer as early as the end of the 19th century has still not lost any of its significance for the life sciences. The basic aspects of ligand-protein interaction may be summarized under the term 'molecular recognition' and concern the specificity as well as stability of ligand binding. Molecular recognition is thus a central topic in the development of active substances, since stability and specificity determine whether a substance can be used as a drug. Nowadays, computer-aided prediction and intelligent molecular design make a large contribution to the constant search for, e. g., improved enzyme inhibitors, and new concepts such as that of pharmacophores are being developed. An up-to-date presentation of an eternally young topic, this book is an indispensable information source for chemists, biochemists and pharmacologists dealing with the binding of ligands to proteins.
Category: Science

Cellular And Biomolecular Recognition

Author : Raz Jelinek
ISBN : 9783527627028
Genre : Science
File Size : 48.93 MB
Format : PDF
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With its exploration of the scientific and technological characteristics of systems exploiting molecular recognition between synthetic materials, such as polymers and nanoparticles, and biological entities, this is a truly multidisciplinary book bridging chemistry, life sciences, pharmacology and medicine. The authors introduce innovative biomimetic chemical assemblies which constitute platforms for recruitment of cellular components or biological molecules, while also focusing on physical, chemical, and biological aspects of biomolecular recognition. The diverse applications covered include biosensors, cell adhesion, synthetic receptors, cell patterning, bioactive nanoparticles, and drug design.
Category: Science

Biological Thermodynamics

Author : Donald T. Haynie
ISBN : 0521795494
Genre : Science
File Size : 68.24 MB
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An accessible introduction to thermodynamics for undergraduate biology and biochemistry students.
Category: Science

Enzyme Kinetics Catalysis And Control

Author : Daniel L. Purich
ISBN : 9780123809254
Genre : Science
File Size : 27.67 MB
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Far more than a comprehensive treatise on initial-rate and fast-reaction kinetics, this one-of-a-kind desk reference places enzyme science in the fuller context of the organic, inorganic, and physical chemical processes occurring within enzyme active sites. Drawing on 2600 references, Enzyme Kinetics: Catalysis & Control develops all the kinetic tools needed to define enzyme catalysis, spanning the entire spectrum (from the basics of chemical kinetics and practical advice on rate measurement, to the very latest work on single-molecule kinetics and mechanoenzyme force generation), while also focusing on the persuasive power of kinetic isotope effects, the design of high-potency drugs, and the behavior of regulatory enzymes. Historical analysis of kinetic principles including advanced enzyme science Provides both theoretical and practical measurements tools Coverage of single molecular kinetics Examination of force generation mechanisms Discussion of organic and inorganic enzyme reactions
Category: Science

Applied Cell And Molecular Biology For Engineers

Author : Gabi Nindl Waite
ISBN : 9780071472425
Genre : Technology & Engineering
File Size : 83.55 MB
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A Guide to the Fundamentals and Latest Concepts of Molecular and Cell Biology Bridging the gap between biology and engineering, Applied Cell and Molecular Biology for Engineers uses clear, straightforward language to introduce you to the cutting-edge concepts of molecular and cell biology. Written by an international team of engineers and life scientists, this vital tool contains “clinical focus boxes” and “applications boxes” in each chapter to link biology and engineering in today's world. To help grasp complex material quickly and easily, a glossary is provided. Applied Cell and Molecular Biology for Engineers features: Clear descriptions of cell structures and functions Detailed coverage of cellular communication In-depth information on cellular energy conversion Concise facts on information flow across generations A succinct guide to the evolution of cells to organisms Inside This Biomedical Engineering Guide Biomolecules: • Energetics • Components of the cell • Cell Morphology: • Cell membranes • Cell organelles • Enzyme Kinetics: • Steady-state kinetics • Enzyme inhibition • Cellular Signal Transduction: • Receptor binding • Apoptosis • Energy Conversion: • Cell metabolism • Cell respiration • Cellular Communication: • Direct • Local • Long distance • Cellular Genetics: • DNA and RNA synthesis and repair • Cell Division and Growth: • Cell cycle • Mitosis • Stem cells • Cellular Development: • Germ cells and fertilization • Limb development • From Cells to Organisms: • Cell differentiation • Systems biology
Category: Technology & Engineering

Plenty Of Room For Biology At The Bottom

Author : Ehud Gazit
ISBN : 9781860946776
Genre : Science
File Size : 61.67 MB
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Written by a leading nanobiologist actively involved at the forefront of the field both as a researcher and an educator, this book takes the reader from the fundamentals of nanobiology to the most advanced applications.The book is written in such a way as to be accessible to biologists and chemists with no background in nanotechnology. It is reader-friendly and will appeal to a wide audience not only in academia but also in the industry and anyone interested in learning more about nanobiotechnology.The book includes a glossary and a selected list of companies actively involved in nanobiotechnology and will be an important reference for those interested in the application aspects of the field.
Category: Science

Die Spezifizit T Der Serologischen Reaktionen

Author : Karl Landsteiner
ISBN : 9783662331132
Genre : Medical
File Size : 65.72 MB
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Dieser Buchtitel ist Teil des Digitalisierungsprojekts Springer Book Archives mit Publikationen, die seit den Anfängen des Verlags von 1842 erschienen sind. Der Verlag stellt mit diesem Archiv Quellen für die historische wie auch die disziplingeschichtliche Forschung zur Verfügung, die jeweils im historischen Kontext betrachtet werden müssen. Dieser Titel erschien in der Zeit vor 1945 und wird daher in seiner zeittypischen politisch-ideologischen Ausrichtung vom Verlag nicht beworben.
Category: Medical