INTRODUCTION TO BIOMOLECULAR ENERGETICS INCLUDING LIGAND RECEPTOR INTERACTIONS

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Introduction To Biomolecular Energetics

Author : Irving Klotz
ISBN : 9780323160995
Genre : Science
File Size : 48.63 MB
Format : PDF
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Introduction to Biomolecular Energetics Including Ligand-Receptor Interactions focuses on the concepts of energetics and their biological applications, including the study of ligand-receptor interactions. The book provides quantitative calculations and addresses topics that have become more prominent in the biochemical and related sciences in recent years, including the first and second laws of thermodynamics, the concept of entropy, free energy or chemical potential, group-transfer potential, physicochemical behavior, and enzyme kinetics. This volume is organized into 10 chapters, and it begins with an overview of the scope of energetics and two general approaches to the field: the classical or phenomenological approach and the statistical-molecular approach. The chapters that follow explore the concepts of energy and entropy in the context of the first and second laws of thermodynamics, along with the relationships between work, heat, energy and entropy as an index of exhaustion. The discussion then shifts to the free energy function and general procedures for computing standard free energies. The book also introduces the reader to the fundamental relationship between chemical potential (free energy) and concentration; high-energy bond and the concept of group-transfer potential; the use of thermodynamic methods in the analysis of physicochemical behavior; and statistical thermodynamics. The final chapter examines the number of ligands that are bound by the receptor entity, how strongly the ligands are held, and the molecular nature of the forces of ligand-receptor interaction. This book will be of interest to biologists and those who want to understand the principles of energetics governing biochemical changes.
Category: Science

Enzyme Kinetics

Author : Hans Bisswanger
ISBN : 9783527806478
Genre : Science
File Size : 70.58 MB
Format : PDF, ePub
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Now in full color for a more intuitive learning experience, this new edition of the long-selling reference also features a number of new developments in methodology and the application of enzyme kinetics. Starting with a description of ligand binding equilibria, the experienced author goes on to discuss simple and complex enzyme reactions in kinetic terms. Special cases such as membrane-bound and immobilized enzymes are considered, as is the influence of external conditions, such as temperature and pH value. The final part of the book then covers a range of widely used measurement methods and compares their performance and scope of application. With its unique mix of theory and practical advice, this is an invaluable aid for teaching as well as for experimental work.
Category: Science

Introduction To Biomolecular Structure And Biophysics

Author : Gauri Misra
ISBN : 9789811049682
Genre : Medical
File Size : 67.51 MB
Format : PDF, ePub
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This comprehensive book presents a modern concept in biophysics based on recently published research. It highlights various aspects of the biophysical fundamentals and techniques that are currently used to study different physical properties of biomolecules, and relates the biological phenomenon with the underlying physical concepts. The content is divided into nine chapters summarizing the structural details of proteins, including recently discovered novel folds, higher order structures of nucleic acids, as well as lipids and the physical forces governing the macromolecular interactions which are essential for the various biological processes. It also provides insights into the recent advances in biophysical techniques including Hydrogen Deuterium Exchange with Mass Spectrometry (HDX-MS), Small angle X-ray scattering (SAXS) and Cryo Electron Microscopy (cryo EM), supplemented with interesting experimental data. It is a valuable reference resource for anyone with a desire to gain a better understanding of the fundamentals of biophysical concepts and techniques of important biomolecules.
Category: Medical

Ligand Receptor Energetics

Author : Irwing M. Klotz
ISBN : 0471176265
Genre : Science
File Size : 68.73 MB
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A foundation for quantitative perspectives and a framework for interpreting experimental observations. Researchers in the life sciences who are unaware of the origins of the fundamental concepts and theoretical constructs in ligand-receptor energetics may fail to recognize the hidden assumptions and premises in their interpretations of observed phenomena. This book offers a detailed exposition of these fundamentals and of the treatment of multiple equilibria in successive steps of the binding of ligands to receptors. It also describes the calculations and meanings of energetic quantities for ligand-receptor complexes. Ligand-Receptor Energetics is the only book on this topic that is both accessible to beginners and extremely useful for experienced investigators. It features numerous specific examples; tables of literature results; extensive, up-to-date thermodynamic data; graphical representations of ligand bonding concepts; and four helpful appendices. Topics covered include: * Affinities -from site, stoichiometric, and ghost-site perspectives * Facts and fantasies from graphical analyses * Numerical evaluation of stoichiometric binding constants * Affinity profiles * Thermodynamic perspectives * Forces of interaction * Molecular scenarios. This valuable supplementary text for students in all areas of the basic life sciences is also an excellent professional reference for researchers in biochemistry, molecular biology, physiology, biophysics, microbiology, neurobiology, immunology, pharmacology, endocrinology, and toxicology.
Category: Science

Cellular And Biomolecular Recognition

Author : Raz Jelinek
ISBN : 9783527627028
Genre : Science
File Size : 29.99 MB
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With its exploration of the scientific and technological characteristics of systems exploiting molecular recognition between synthetic materials, such as polymers and nanoparticles, and biological entities, this is a truly multidisciplinary book bridging chemistry, life sciences, pharmacology and medicine. The authors introduce innovative biomimetic chemical assemblies which constitute platforms for recruitment of cellular components or biological molecules, while also focusing on physical, chemical, and biological aspects of biomolecular recognition. The diverse applications covered include biosensors, cell adhesion, synthetic receptors, cell patterning, bioactive nanoparticles, and drug design.
Category: Science

Biological Thermodynamics

Author : Donald T. Haynie
ISBN : 0521795494
Genre : Science
File Size : 46.7 MB
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An accessible introduction to thermodynamics for undergraduate biology and biochemistry students.
Category: Science

Diamond Dealers And Feather Merchants

Author : KLOTZ
ISBN : 9781489935298
Genre : Science
File Size : 78.68 MB
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To paraphrase Saul Bellow, it is extremely difficult to escape from the conceptual bottles into which we have been processed, or even to become aware that we are confined within them. Anthro pocentrism, an ancient tradition, is an intellectual constraint that has continually impeded objective probing of the universe around and within us. We are probably born with that constriction, perhaps as a result of evolutionary selection or because each of us has been created in the image of the Deity. But it is only the core of our mental "gestalt. " Around it we find additional shells of intellectual obstruc tions deposited by accretion from our family, our teachers, our experi ences and the society in which we are immersed. It is very hazardous to embrace novel scientific ideas. Personal and social experiences show that the vast majority turn out to be failures. What standards can one use to make judgments? There is a universal tendency to rely on "common sense;" but as Einstein pointed out, this is a collection of views, sensible or not, imprinted in us before the age of sixteen. I have found it a challenge to convince young students that much of what they are certain about and, in fact, correct about, is actually contrary to common sense. For example, on any bright day, anyone who is not blind or an idiot can see the sun literally moving around the earth, from east to west.
Category: Science

Biomolecular Simulations

Author : Luca Monticelli
ISBN : 1493958917
Genre : Computers
File Size : 60.76 MB
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This Methods in Molecular Biology volume reviews common methods used in molecular modeling of biological systems, including methods for electronic structure calculations, classical molecular dynamics simulations and coarse-grained techniques."
Category: Computers

Structure Based Drug Discovery

Author : Leslie W. Tari
ISBN : 1617795194
Genre : Medical
File Size : 30.6 MB
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The last decade has seen the confluence of several enabling technologies that have allowed protein crystallographic methods to live up to their true potential. Taken together, the numerous recent advances have made it possible to tackle difficult biological targets with a high probability of success: intact bacterial ribosomes have been structurally elucidated, as well as eukaryotic trans-membrane proteins like the potassium channel and GPCRs. It is now possible for medicinal chemists to have access to structural information on their latest small molecule candidates bound to the therapeutic target within days of compound synthesis, allowing structure guided ligand optimization to occur in "real time". Structure-Based Drug Discovery presents an array of methods used to generate crystal structures of biological macromolecules, how to leverage the structural information to design novel ligands anew, and how to iteratively optimize hits and convert them to leads. Written in the successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Structure-Based Drug Discovery aims to provide scientists interested in adding SBDD to their arsenal of drug discovery methods with well-honed, up-to-date methodologies.
Category: Medical

Molecular Neuropharmacology

Author : Arne Schousboe
ISBN : 9781592596720
Genre : Medical
File Size : 80.18 MB
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A powerful collection of readily reproducible cutting-edge techniques for characterizing the ligand or substrate binding of neurotransmitter receptors and transporters. The procedures cover interdisciplinary interactions for monoamine transporters, amino acid transporters, ionotropic receptors, metabotropic glutamate receptors, GABA receptors, and other G protein-coupled receptors. By illuminating how neurons in the central nervous communicate with other, these techniques can lead to the development of novel therapeutic strategies for neurological diseases.
Category: Medical