GENOMES AND WHAT TO MAKE OF THEM

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Genomes And What To Make Of Them

Author : Barry Barnes
ISBN : 9781459605930
Genre : Genomes
File Size : 66.93 MB
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The announcement in 2003 that the Human Genome Project had completed its map of the entire human genome was heralded as a stunning scientific breakthrough: our first full picture of the basic building blocks of human life. Since then, boasts about the benefits - and warnings of the dangers - of genomics have remained front-page news, with everyone agreeing that genomics has the potential to radically alter life as we know it. For the nonscientist, the claims and counterclaims are dizzying - what does it really mean to understand the genome? Barry Barnes and John Dupr offer an answer to that question and much more in Genomes and What to Make of Them, a clear and lively account of the genomic revolution and its promise. The book opens with a brief history of the science of genetics and genomics, from Mendel to Watson and Crick and all the way up to Craig Venter; from there the authors delve into the use of genomics in determining evolutionary paths - and what it can tell us, for example, about how far we really have come from our ape ancestors. Barnes and Dupr then consider both the power and risks of genetics, from the economic potential of plant genomes to overblown claims that certain human genes can be directly tied to such traits as intelligence or homosexuality. Ultimately, the authors argue, we are now living with a new knowledge as powerful in its way as nuclear physics, and the stark choices that face us - between biological warfare and gene therapy, a new eugenics or a new agricultural revolution - will demand the full engagement of both scientists and citizens. Written in straightforward language but without denying the complexity of the issues, Genomes and What to Make of Them is both an up-to-date primer and a blueprint for the future.
Category: Genomes

Ancestors In Our Genome

Author : Eugene E. Harris
ISBN : 9780199978205
Genre : Science
File Size : 29.67 MB
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In 2001, scientists were finally able to determine the full human genome sequence, and with the discovery began a genomic voyage back in time. Since then, we have sequenced the full genomes of a number of mankind's primate relatives at a remarkable rate. The genomes of the common chimpanzee (2005) and bonobo (2012), orangutan (2011), gorilla (2012), and macaque monkey (2007) have already been identified, and the determination of other primate genomes is well underway. Researchers are beginning to unravel our full genomic history, comparing it with closely related species to answer age-old questions about how and when we evolved. For the first time, we are finding our own ancestors in our genome and are thereby gleaning new information about our evolutionary past. In Ancestors in Our Genome, molecular anthropologist Eugene E. Harris presents us with a complete and up-to-date account of the evolution of the human genome and our species. Written from the perspective of population genetics, and in simple terms, the book traces human origins back to their source among our earliest human ancestors, and explains many of the most intriguing questions that genome scientists are currently working to answer. For example, what does the high level of discordance among the gene trees of humans and the African great apes tell us about our respective separations from our common ancestor? Was our separation from the apes fast or slow, and when and why did it occur? Where, when, and how did our modern species evolve? How do we search across genomes to find the genomic underpinnings of our large and complex brains and language abilities? How can we find the genomic bases for life at high altitudes, for lactose tolerance, resistance to disease, and for our different skin pigmentations? How and when did we interbreed with Neandertals and the recently discovered ancient Denisovans of Asia? Harris draws upon extensive experience researching primate evolution in order to deliver a lively and thorough history of human evolution. Ancestors in Our Genome is the most complete discussion of our current understanding of the human genome available.
Category: Science

Fungal Genomics

Author :
ISBN : 0080527450
Genre : Science
File Size : 85.94 MB
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The purpose of this volume is to highlight wide-ranging applications of genomics in the area of applied mycology and biotechnology. The volume covers: a brief overview on fungal genomics; meiotic recombination in fungi; molecular genetics of circadian rhythms; genome sequencing; transposable elements; mitochondrial genomes; ribosome biogenesis; pathogenicity genes; genetic improvement of yeasts; microarrays: techniques and applications; fungal germplasm and data bases. Although it is difficult to develop a comprehensive volume on fungal genomics because of the range and complexity of the emerging knowledge, an attempt has been made to bring together pertinent information that will serve the needs of the reader, provide a quick reference to material that might otherwise be difficult to locate, and furnish a starting point for further study.
Category: Science

Wired For Culture Origins Of The Human Social Mind

Author : Mark Pagel
ISBN : 9780393063158
Genre : Science
File Size : 82.48 MB
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“Does an excellent job of using evolutionary biology to discuss the origins of religion, music, art, and . . . morality.”—Publishers Weekly, starred review A unique trait of the human species is that our personalities, lifestyles, and worldviews are shaped by an accident of birth—namely, the culture into which we are born. It is our cultures and not our genes that determine which foods we eat, which languages we speak, which people we love and marry, and which people we kill in war. But how did our species develop a mind that is hardwired for culture—and why? Evolutionary biologist Mark Pagel tracks this intriguing question through the last 80,000 years of human evolution, revealing how an innate propensity to contribute and conform to the culture of our birth not only enabled human survival and progress in the past but also continues to influence our behavior today. Shedding light on our species’ defining attributes—from art, morality, and altruism to self-interest, deception, and prejudice—Wired for Culture offers surprising new insights into what it means to be human.
Category: Science

Introduction To Computational Genomics

Author : Nello Cristianini
ISBN : 9781139460156
Genre : Computers
File Size : 63.25 MB
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Where did SARS come from? Have we inherited genes from Neanderthals? How do plants use their internal clock? The genomic revolution in biology enables us to answer such questions. But the revolution would have been impossible without the support of powerful computational and statistical methods that enable us to exploit genomic data. Many universities are introducing courses to train the next generation of bioinformaticians: biologists fluent in mathematics and computer science, and data analysts familiar with biology. This readable and entertaining book, based on successful taught courses, provides a roadmap to navigate entry to this field. It guides the reader through key achievements of bioinformatics, using a hands-on approach. Statistical sequence analysis, sequence alignment, hidden Markov models, gene and motif finding and more, are introduced in a rigorous yet accessible way. A companion website provides the reader with Matlab-related software tools for reproducing the steps demonstrated in the book.
Category: Computers

Computational Methods In Genome Research

Author : Sándor Suhai
ISBN : 0306447126
Genre : Medical
File Size : 46.92 MB
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Can computational science keep up with evolving technology for genome mapping and sequencing?; Informatics and experiments for the human genome project; Data management tools for scientific applications: framework, status, and genomic applications; The ACEDB genome database; The integrated genomic database (IGD); Genetic mapping, an overview; Representing genomic maps in a relational database; Livermore's pragmatic approach to integrated mapping for chromosome 19; Searching protein sequence databases - is optimal best?; Algorithmic advances for searching biosequence databases; Pattern recognition in genomic and protein sequences: a survey of statistical validation problems; New algorithms for the computational of evolutionary phylogenetic trees; Modelling protein structure from remote sequence similarity: an approach to tertiary structure prediction; Genetic algorithms in protein structure prediction; Applications of artificial neural networks in genome research; Statistical models of chromosome evolution; Deciphering the genetic message: some thoughts onf present limits.
Category: Medical

From Genes To Genomes

Author : Jeremy W. Dale
ISBN : 9781119954279
Genre : Science
File Size : 47.41 MB
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The latest edition of this highly successful textbook introduces the key techniques and concepts involved in cloning genes and in studying their expression and variation. The new edition features: Increased coverage of whole-genome sequencing technologies and enhanced treatment of bioinformatics. Clear, two-colour diagrams throughout. A dedicated website including all figures. Noted for its outstanding balance between clarity of coverage and level of detail, this book provides an excellent introduction to the fast moving world of molecular genetics.
Category: Science

Exploring Horizons For Domestic Animal Genomics

Author : National Research Council
ISBN : 9780309085052
Genre : Science
File Size : 71.30 MB
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Recognizing the important contributions that genomic analysis can make to agriculture, production and companion animal science, evolutionary biology, and human health with respect to the creation of models for genetic disorders, the National Academies convened a group of individuals to plan a public workshop that would: (1) assess these contributions; (2) identify potential research directions for existing genomics programs; and (3) highlight the opportunities of a coordinated, multi-species genomics effort for the science and policymaking communities. Their efforts culminated in a workshop sponsored by the U.S. Department of Agriculture, Department of Energy, National Science Foundation, and the National Institutes of Health. The workshop was convened on February 19, 2002. The goal of the workshop was to focus on domestic animal genomics and its integration with other genomics and functional genomics projects.
Category: Science

Viruses And Human Disease

Author : Ellen G. Strauss
ISBN : 0080553168
Genre : Science
File Size : 60.61 MB
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Completely revised and updated, the new edition of this groundbreaking text integrates basic virology with pathophysiological conditions to examine the connection between virology and human disease. Most virology textbooks focus on the molecular biology involved without adequate reference to physiology. This text focuses on viruses that infect humans, domestic animals and vertebrates and is based on extensive course notes from James Strauss’ virology class at the California Institute of Technology taught for over 30 years. Expertly depicting in color the molecular structure and replication of each virus, it provides an excellent overview for students and professionals interested in viruses as agents of human disease. Includes over 30% new material - virtually all of the figures and tables have been redrawn to include the latest information and the text has been extensively rewritten to include the most up-to-date information Includes a new chapter on emerging and reemerging viral diseases such as avian flu, SARS, the spread of West Nile virus across America, and the continuing spread of Nipah virus in Southeast Asia Further reading sections at the end of each chapter make it easy find key references World maps depicting the current distribution of existing and newly emerging viruses are also incorporated into the text
Category: Science

Chemistry And The Human Genome

Author : Ted Lister
ISBN : 0854043969
Genre : Science
File Size : 71.4 MB
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"On 15th February 2001, two groups of scientists published a draft that described the complete chemical makeup of human genes - the human genome as it is often called. The discovery of the sequence of the human genome has been hailed as one of the most important scientific advances ever. This would not have been possible without the work of chemists and chemical scientists. This resource aims to show students and teachers the chemical science behind the discovery at a level suitable for post-16 students of chemistry and biology and also to place it in the context of science in the 21st century." "It is hoped that teachers of both biology and chemistry at post-16 level will use it to enthuse their students to perhaps go on to study the proteome and beyond." "This book was produced as part of the Royal Society of Chemistry's programme for the support of education in the field of the chemical sciences."--BOOK JACKET.
Category: Science