GABA AND THE BASAL GANGLIA 160 PROGRESS IN BRAIN RESEARCH

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Gaba And The Basal Ganglia

Author : J. M. Tepper
ISBN : 0080480470
Genre : Science
File Size : 45.45 MB
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Over the past 25 years the amount of data pertaining to the GABAergic function in the basal ganglia has increased dramatically. GABA and the Basal Ganglia - From Molecules to Systems is a comprehensive review of the current state-of-the-art of knowledge about the neuroanatomy, neuropharmacology and neurophysiology of the basal ganglia, focusing on its GABAergic microcircuitry. It serves as a complete reference to the body of knowledge about the basal ganglia, its constituent neurons, and their interconnections. This volume is designed to serve as a convenient all-in-one review and reference for experienced basal ganglia researchers as well as an introduction to the functional organization of the basal ganglia and its GABAergic circuitry for students and researchers new to the field. * Reviews the anatomy, physiology and pharmacology of the basal ganglia itself in addition to focusing on the GABAergic circuitry of the basal ganglia * Authors of each chapter leading internationally acclaimed experts in basal ganglia research
Category: Science

Diversity And Functions Of Gaba Receptors A Tribute To Hanns M Hler

Author :
ISBN : 9780128026915
Genre : Medical
File Size : 87.31 MB
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Diversity and Functions of GABA Receptors: A Tribute to Hanns Möhler, Part B, a new volume of Advances in Pharmacology, presents the diversity and functions of GABA Receptors. The volume looks at research performed in the past 20 years, which has revealed specific physiological and pharmacological functions of individual GABAA receptor subtypes, providing novel opportunities for drug development. Contributions from the best authors in the field An essential resource for pharmacologists, immunologists, and biochemists
Category: Medical

The Rat Nervous System

Author : George Paxinos
ISBN : 9780080921372
Genre : Science
File Size : 33.29 MB
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The previous editions of The Rat Nervous System were indispensable guides for those working on the rat and mouse as experimental models. The fourth edition enhances this tradition, providing the latest information in the very active field of research on the brain, spinal cord, and peripheral nervous system. The structure, connections, and function are explained in exquisite detail, making this an essential book for any graduate student or scientist working on the rat or mouse nervous system. Completely revised and updated content throughout, with entirely new chapters added Beautifully illustrated so that even difficult concepts are rendered comprehensible Provides a fundamental analysis of the anatomy of all areas of the central and peripheral nervous systems, as well as an introduction to their functions Appeals to researchers working on other species, including humans
Category: Science

Dopamine Glutamate Interactions In The Basal Ganglia

Author : Susan Jones
ISBN : 9781420088809
Genre : Science
File Size : 86.72 MB
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The basal ganglia are involved in complex brain functions, from voluntary movement control to learning and reward processing, and they are implicated in numerous neurological and psychiatric disorders. Information from the cerebral cortex and thalamus is conveyed to basal ganglia nuclei via glutamate release, while dopamine from the midbrain is released in close proximity to glutamate. At the heart of both function and dysfunction of basal ganglia circuits is the interaction of these two neurotransmitters, dopamine and glutamate. Elucidating the relationship between their molecular and cellular effects and behavioural significance has been challenging, but in the past 5–10 years, improved labeling, imaging, recording, and genetic manipulation approaches have yielded new information on how dopamine and glutamate interact to generate the circuit activity underpinning basal ganglia function. Dopamine–Glutamate Interactions in the Basal Ganglia synthesizes this recent research from the level of receptor molecules all the way to complex behaviours and disease. Current insights from research on individual neurons and synapses, detailed circuit analysis, and learning and action functions of the basal ganglia are presented against a historical perspective. The book also discusses compromised dopamine–glutamate interaction in disorders of basal ganglia function, including Parkinson’s disease, Huntington’s disease, and drug addiction.
Category: Science

Magnetic Resonance Spectroscopy

Author : Charlotte Stagg
ISBN : 9780124016972
Genre : Medical
File Size : 87.79 MB
Format : PDF
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Magnetic Resonance Spectroscopy: Tools for Neuroscience Research and Emerging Clinical Applications is the first comprehensive book for non-physicists that addresses the emerging and exciting technique of magnetic resonance spectroscopy. Divided into three sections, this book provides coverage of the key areas of concern for researchers. The first, on how MRS is acquired, provides a comprehensive overview of the techniques, analysis, and pitfalls encountered in MRS; the second, on what can be seen by MRS, provides essential background physiology and biochemistry on the major metabolites studied; the final sections, on why MRS is used, constitutes a detailed guide to the major clinical and scientific uses of MRS, the current state of teh art, and recent innovations. Magnetic Resonance Spectroscopy will become the essential guide for people new to the technique and give those more familiar with MRS a new perspective. Chapters written by world-leading experts in the field Fully illustrated Covers both proton and non-proton MRS Includes the background to novel MRS imaging approaches
Category: Medical

Cultural Neuroscience Cultural Influences On Brain Function

Author : Juan Y. Chiao
ISBN : 9780080952215
Genre : Science
File Size : 73.63 MB
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This volume presents recent empirical advances using neuroscience techniques to investigate how culture influences neural processes underlying a wide range of human abilities, from perception and scene processing to memory and social cognition. It also highlights the theoretical and methodological issues with conducting cultural neuroscience research. Section I provides diverse theoretical perspectives on how culture and biology interact are represented. Sections II –VI is to demonstrate how cultural values, beliefs, practices and experience affect neural systems underlying a wide range of human behavior from perception and cognition to emotion, social cognition and decision-making. The final section presents arguments for integrating the study of culture and the human brain by providing an explicit articulation of how the study of culture can inform the study of the brain and vice versa.
Category: Science

Gaba And The Basal Ganglia

Author : Gaetano Di Chiara
ISBN : UCSD:31822010309516
Genre : Aminobutyric acid
File Size : 53.14 MB
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Category: Aminobutyric acid

The Basal Ganglia Vi

Author : Ann M. Graybiel
ISBN : 9781461501794
Genre : Medical
File Size : 38.90 MB
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This volume, the sixth in the IBAGS series, summarizes major contributions in clinical and basic research on the basal ganglia. The sixth meeting of the Society was held on Cape Cod, in the state of Massachusetts, USA, in October, 1998. Altogether 16 countries were represented by 227 participants. This volume contains papers contributed by participants. The focus of the sixth triennial IBAGS meeting, and of this volume, was to bring to gether leaders in basic and clinical science to address two sets of still-persisting questions in the field. The first set focuses on the functions of the basal ganglia in health and disease: What are the core functions of the basal ganglia and cortico-basal ganglia loops? How are these core functions disrupted in disorders affecting the basal ganglia? How do we account for the broad range of behaviors affected by basal ganglia disorders and for the increasing evidence that the basal ganglia influence cognitive as well as motor functions? These issues are addressed in the first five sections of the current volume, which summarize advances in the study of basal ganglia disorders based on studies in humans (Section 1), new results obtained with experimental animal models of basal ganglia disorders (Section 2), results of experiments on information coding in the basal ganglia (Section 3) and new information about functions of the basal ganglia related to learning and adaptive motor control (Section 4).
Category: Medical

Annals Of The New York Academy Of Sciences Drug Addiction

Author : Syed F. Ali
ISBN : STANFORD:36105131941945
Genre : Psychology
File Size : 21.89 MB
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This volume brings together basic and clinical science to provide in-depth understanding and current knowledge concerning new conceptual insights into the CNS acting drugs and drugs of abuse and treatment of drug addiction. Methamphetamine, MDMA, PMA and different solvents are the most widely abused drugs in the Europe, United States, Central America, South America and Asian Countries and their use has dramatically increased over the last two decades. These drugs of abuse are known to cause neurotoxicity in several species including not only rodents, dogs and nonhuman primates, but also humans. However, precise neurochemical mechanisms underlying this drug-induced neurotoxicity remain unclear. This volume addresses the following: 1) Role of Genomics, Proteomics and Metabonomics in Drug-induced Neurotoxicity 2) Drugs of Abuse and Medication Development 3) Molecular Biology and Free Radicals in Drugs of Abuse-induced neurotoxicity 4) Substituted Amphetamines-induced Neurochemical Changes and Relationship to Neurotoxicity 5) Drug of Abuse and Imaging Brain Structure and Function 6) GHB/Volatile Solvent/Inhalant Neurotoxicity NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member
Category: Psychology

Fundamental Neuroscience

Author : Larry R. Squire
ISBN : 9780123858702
Genre : Medical
File Size : 57.24 MB
Format : PDF, Docs
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Fundamental Neuroscience, 3rd Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts. A companion web site contains test questions, and an imagebank of the figures for ready use in presentations, slides, and handouts. Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! New to this edition: * 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness * Companion website with figures, web links to additional material, and test questions * Additional text boxes describing key experiments, disorders, methods, and concepts * Multiple model system coverage beyond rats, mice, and monkeys * Extensively expanded index for easier referencing
Category: Medical