FOUNDATIONS OF STRUCTURAL BIOLOGY

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Foundations Of Structural Biology

Author : Leonard J. Banaszak
ISBN : 0080521843
Genre : Science
File Size : 62.49 MB
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Imagine trying to understand an engine without visualizing its moving parts. Biological processes involve far more complex chemical reactions and components than any engine. Furthermore, the parts work together to do many more functions than an engine which sole task is to turn a shaft. Understanding the implications of the three-dimensional coordinates for a molecule with several thousand atoms requires an understanding of, and practice with, 3D imaging. For many biologists, this means acquiring a whole new set of skills. Foundations of Structural Biology is aimed at helping the reader develop visualization skills for protein or DNA segments, while also describing the fundamental principles underlying the organization and interaction between these complex molecules. Key Features * Explains how to use coordinate databases and atomic coordinates of biological macromolecules * Teaches the skills of stereoviewing * Contains computer-generated stereographics * Describes the principles of symmetry and handedness in proteins and DNA * Introduces metal and lipid binding proteins and DNA-protein interactions * Explains the principles involved in understanding secondary and quaternary structure * Includes coverage of protein-metal, protein-nucleic acid, and protein-lipid interactions
Category: Science

Membrane Structural Biology

Author : Mary Luckey
ISBN : 9781107729339
Genre : Science
File Size : 81.69 MB
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This textbook provides a strong foundation and a clear overview for students of membrane biology and an invaluable synthesis of cutting-edge research for working scientists. The text retains its clear and engaging style, providing a solid background in membrane biochemistry, while also incorporating the approaches of biophysics, genetics and cell biology to investigations of membrane structure, function and biogenesis to provide a unique overview of this fast-moving field. A wealth of new high resolution structures of membrane proteins are presented, including the Na/K pump and a receptor-G protein complex, offering exciting insights into how they function. All key tools of current membrane research are described, including detergents and model systems, bioinformatics, protein-folding methodology, crystallography and diffraction, and molecular modeling. This comprehensive and up-to-date text, emphasising the correlations between membrane research and human health, provides a solid foundation for all those working in this field.
Category: Science

Algorithms In Structural Molecular Biology

Author : Bruce R. Donald
ISBN : 9780262297844
Genre : Science
File Size : 23.48 MB
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Using the tools of information technology to understand the molecular machinery of the cell offers both challenges and opportunities to computational scientists. Over the past decade, novel algorithms have been developed both for analyzing biological data and for synthetic biology problems such as protein engineering. This book explains the algorithmic foundations and computational approaches underlying areas of structural biology including NMR (nuclear magnetic resonance); X-ray crystallography; and the design and analysis of proteins, peptides, and small molecules.Each chapter offers a concise overview of important concepts, focusing on a key topic in the field. Four chapters offer a short course in algorithmic and computational issues related to NMR structural biology, giving the reader a useful toolkit with which to approach the fascinating yet thorny computational problems in this area. A recurrent theme is understanding the interplay between biophysical experiments and computational algorithms. The text emphasizes the mathematical foundations of structural biology while maintaining a balance between algorithms and a nuanced understanding of experimental data. Three emerging areas, particularly fertile ground for research students, are highlighted: NMR methodology, design of proteins and other molecules, and the modeling of protein flexibility.The next generation of computational structural biologists will need training in geometric algorithms, provably good approximation algorithms, scientific computation, and an array of techniques for handling noise and uncertainty in combinatorial geometry and computational biophysics. This book is an essential guide for young scientists on their way to research success in this exciting field.
Category: Science

Nmr In Structural Biology

Author : Kurt Wüthrich
ISBN : 9789814500494
Genre : Science
File Size : 38.16 MB
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The volume presents a survey of the research by Kurt Wüthrich and his associates during the period 1965 to 1994. A selection of reprints of original papers on the use of NMR spectroscopy in structural biology is supplemented with an introduction, which outlines the foundations and the historical development of the use of NMR spectroscopy for the determination of three-dimensional structures of biological macromolecules in solution. The original papers are presented in groups highlighting protein structure determination by NMR, studies of dynamic properties and hydration of biological macromolecules, and practical applications of the NMR methodology in fields such as enzymology, transcriptional regulation, immunosuppression and protein folding. Contents: NMR and Structural BiologyThe Avenue to Three-Dimensional Protein Structure Determination in SolutionEstablishing Credibility for NMR Structures of ProteinsEvolution of NMR Structure Determination with Biological Macromolecules 1985–94Selected NMR Structure DeterminationsConformational Equilibria and Internal Mobility in Proteins in SolutionHydration of Proteins and Nucleic Acids in SolutionProtein Foldingappendices, an author index and a subject index Readership: Chemists, biochemists and molecular & cell biology scientists. keywords:Structural Biology;Nuclear Magnetic Resonance Spectroscopy (NMR);Protein Structure;Protein Dynamics;Protein Hydration;Structure-Based Drug Design;Intramolecular Interactions with Proteins;Structure-Function Correlations in Proteins;NMR Techniques;Distance Geometry for Protein Structure Calculation
Category: Science

Computational Chemistry Methods In Structural Biology

Author : Christo Christov
ISBN : 9780123864857
Genre : Science
File Size : 65.94 MB
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Published continuously since 1944, the Advances in Protein Chemistry and Structural Biology serial has been a continuous, essential resource for protein chemists. Covering reviews of methodology and research in all aspects of protein chemistry, including purification/expression, proteomics, modeling and structural determination and design, each volume brings forth new information about protocols and analysis of proteins while presenting the most recent findings from leading experts in a broad range of protein-related topics. This volume features articles on Computational Chemistry methods in Structural Biology. Essential resource for protein chemists This volume features articles on Computational Chemistry methods in Structural Biology
Category: Science

Foundations Of Comparative Genomics

Author : Arcady R. Mushegian
ISBN : 0080546099
Genre : Science
File Size : 44.53 MB
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This book provides an overview of computational analysis of genes and genomes, and of some most notable findings that come out of this work. Foundations of Comparative Genomics presents a historical perspective, beginning with early analysis of individual gene sequences, to present day comparison of gene repertoires encoded by completely sequenced genomes. The author discusses the underlying scientific principles of comparative genomics, argues that completion of many genome sequences started a new era in biology, and provides a personal view on several state-of-the-art issues, such as systems biology and whole-genome phylogenetic reconstructions. This book is an essential reference for researchers and students in computational biology, evolutionary biology, and genetics. Presents an historic overview of genome biology and its achievements Includes topics not covered in other books such as minimal and ancestral genomes Discusses the evolutionary resilience of protein-coding genes and frequent functional convergence at the molecular level Critically reviews horizontal gene transfer and other contentious issues Covers comparative virology as a somewhat overlooked foundation of modern genome science
Category: Science

Biological Foundations Of Linguistic Communication

Author : Thomas T. Ballmer
ISBN : 9789027280589
Genre : Language Arts & Disciplines
File Size : 51.56 MB
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This is the second of two volumes – the first volume being Waltraud Brennenstuhl’s Control and Ability (P&B III:4) – treating biocybernetical questions of language. This book starts out from an investigation of the (neuro-)biological relevancy of natural language from the point of view of grammar and the lexicon. Furthermore, the basic mechanisms of the self-organization of organisms in their environments are discussed, in so far as they lead to linguistic control and abilities.
Category: Language Arts & Disciplines

Pflanzenbiochemie

Author : Hans Walter Heldt
ISBN : 9783662443989
Genre : Science
File Size : 32.63 MB
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Die „Pflanzenbiochemie" hat sich im deutschsprachigen Raum, aber auch in zahlreichen Übersetzungen als Standardlehrbuch etabliert. Birgit Piechulla, Dozentin an der Universität Rostock, zeichnet als Co-Autorin bei dieser 5. Auflage verantwortlich und hat zusammen mit Hans-Walter Heldt das Buch gründlich überarbeitet und aktualisiert. Neueste wissenschaftliche Erkenntnisse fanden Eingang in dieses Buch, die sich auch in neuen Abbildungen sowie der stark überarbeiteten Literatur widerspiegeln. Besonderen Wert legen die Autoren darauf, die offenen, zukunftsweisenden Fragen, die den derzeitigen Stand unseres Wissens markieren, aufzuzeigen. Aktualität sowie die klare und verständliche Didaktik komplexer Sachverhalte darzustellen -- das sind die Kennzeichen dieses Lehrbuches. Mit sorgfältig erstellten zweifarbigen Abbildungen erfüllt es einen hohen didaktischen Anspruch und reiht sich unter die besten Biochemie-Lehrbücher.
Category: Science

X Plor

Author : Axel T. Brünger
ISBN : 0300054025
Genre : Computers
File Size : 36.37 MB
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X-PLOR is a highly sophisticated computer program that provides an interface between theoretical foundations and experimental data in structural biology, with specific emphasis on X-ray crystallography and nuclear magnetic resonance spectroscopy in solution of large biological macro-molecules. This manual to X-PLOR Version 3.1 presents the theoretical background, syntax, and function of the program and also provides a comprehensive list of references and sample input files with comments. It is intended primarily for researchers and students in the fields of computational chemistry, structural biology, and computational molecular biology.
Category: Computers