FORENSIC APPLICATIONS OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHY ANALYTICAL CONCEPTS IN FORENSIC CHEMISTRY

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Forensic Applications Of High Performance Liquid Chromatography

Author : Shirley Bayne
ISBN : 9781439882597
Genre : Law
File Size : 72.43 MB
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Chromatography has many roles in forensic science, ranging from toxicology to environmental analysis. In particular, high-performance liquid chromatography (HPLC) is a primary method of analysis in many types of laboratories. Maintaining a balance between practical solutions and the theoretical considerations involved in HPLC analysis, Forensic Applications of High Performance Liquid Chromatography uses real-life examples likely to be found within a forensic science laboratory to explain HPLC from a forensic perspective. Focusing chiefly on the reverse phase HPLC mode of separation, this volume examines: The history of HPLC and the theory behind the separation process The requirements for successful analysis and best practice tips The modes of separation and detection most appropriate for forensic science applications HPLC method development and evaluation The quality aspects of laboratory operation Troubleshooting HPLC systems and analyses Applications of HPLC within the field of forensic science Designed as a textbook for university students studying analytical chemistry, applied chemistry, forensic chemistry, or other courses with an element of HPLC within the course curriculum, this volume is also an invaluable guide for those in the early stages of their forensic analysis careers. An instructor’s manual with lecture slides, test bank, objectives, and exercises is available with qualifying course adoption
Category: Law

Forensic Applications Of Gas Chromatography

Author : Michelle Groves Carlin
ISBN : 9781466507548
Genre : Law
File Size : 84.82 MB
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Several areas of forensic science use the technique of gas chromatography, ranging from fire analysis to the investigation of fraudulent food and perfumes. Covering the essentials of this powerful analytical technique, Forensic Applications of Gas Chromatography explains the theory and shows applications of this knowledge to various realms of forensic science. Topics include: A brief introduction to gas chromatography and its use in forensic science Various components that make up the gas chromatographic instrumentation The theory of the separation process, along with the chemistry underpinning the process Method development, with a specific example of a separation of eight different compounds using a gas chromatography-flame ionization detector Quality assurance and method validation—with information applicable to many types of analytical testing laboratories Troubleshooting in gas chromatography systems New developments in gas chromatography and advances in columns and detectors Real examples supplement the text, along with questions in each chapter. The book includes examples of applications of gas chromatography in drugs, toxicology, fire, paint, food, and fragrance. Each application is presented as an individual case study with specific focus on a particular sample preparation technique. This allows each technique to be discussed with respect to its theory, instrumentation, solvent selection, and function, as appropriate. Each case study provides readers with suitable practical information to allow them to perform experiments in their own laboratory either as part of a practical laboratory class or in a research context. The final chapter provides answers to the questions and encourages further study and discussion.
Category: Law

Hplc In Enzymatic Analysis

Author : Edward F. Rossomando
ISBN : 9780470111000
Genre : Science
File Size : 81.62 MB
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The use of High Performance Liquid Chromatography (HPLC) techniques in the study of enzymatic reactions has grown significantly since the publication of the first edition of this highly successful book: the role of enzymes in biological research has expanded; the application of HPLC and enzymes has extended to more disciplines; advances in separation techniques and instrumentation have increased the capability of HPLC; and the discovery of new enzymes has spawned new methods of analysis. High Performance Liquid Chromatography in Enzymatic Analysis, Second Edition addresses these developments in its coverage of the refinements of HPLC methods and their use in a wide range of laboratory applications. It offers the same practical approach found in the first edition, incorporates a wealth of new information into existing chapters, and adds new chapters to deal with new applications, including capillary electrophoresis, forensic chemistry, microdialysis, and the polymerase chain reaction. Topics include: * Application of HPLC to the assay of enzymatic activities * Concepts and principles of HPLC, including the latest technological advances * Concepts and principles of capillary electrophoresis (CE) * Strategy for design of an HPLC/CE system for assay of enzyme activity * Preparation of enzymatic activities from tissues and single cells * Analysis of enzymatic activities in body fluids, including chromatobiosis * HPLC for the identification of new enzymatic activities * Fundamentals of the polymerase chain reaction * HPLC in forensics * Survey of enzymatic activities assayed by the HPLC method, including many new categories * Multienzyme systems, including many new examples * HPLC in the analysis of contaminated food "It is the ability of HPLC to accomplish separations completely and rapidly that led to its original application to problems in the life sciences, particularly those related to purification. An analysis of the literature revealed that this technique was used primarily for the purification of small molecules, macromolecules such as peptides and proteins, and more recently, antibodies. This application to purification has all but dominated the use of the method, and there has been a plethora of books, symposia, and conferences on the use of HPLC for these purposes. However, it was only a matter of time before others began to look beyond and to explore the possibilities that result from the capacity to make separations quickly and efficiently." --from the preface to the First Edition Easy to read and full of practical advice and hundreds of diagrams and examples, High Performance Liquid Chromatography in Enzymatic Analysis, Second Edition is an invaluable resource for students, researchers, and laboratory workers in analytical chemistry and biochemistry, molecular biology and cell biology, and for anyone interested in keeping up with this fast-growing field.
Category: Science

Advances In Food Authenticity Testing

Author : Gerard Downey
ISBN : 9780081002339
Genre : Technology & Engineering
File Size : 71.27 MB
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Advances in Food Authenticity Testing covers a topic that is of great importance to both the food industry whose responsibility it is to provide clear and accurate labeling of their products and maintain food safety and the government agencies and organizations that are tasked with the verification of claims of food authenticity. The adulteration of foods with cheaper alternatives has a long history, but the analytical techniques which can be implemented to test for these are ever advancing. The book covers the wide range of methods and techniques utilized in the testing of food authenticity, including new implementations and processes. The first part of the book examines, in detail, the scientific basis and the process of how these techniques are used, while other sections highlight specific examples of the use of these techniques in the testing of various foods. Written by experts in both academia and industry, the book provides the most up-to-date and comprehensive coverage of this important and rapidly progressing field. Covers a topic that is of great importance to both the food industry and the governmental agencies tasked with verifying the safety and authenticity of food products Presents a wide range of methods and techniques utilized in the testing of food authenticity, including new implementations and processes Highlights specific examples of the use of the emerging techniques and testing strategies for various foods
Category: Technology & Engineering

Multidimensional Chromatography

Author : Luigi Mondello
ISBN : 0471988693
Genre : Science
File Size : 86.77 MB
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Coupled High Performance Liquid Chromatography with High Resolution Gas Chromatography (L. Mondello); Multidimensional High Resolution Gas Chromatography (A.C. Lewis); Orthogonal GC-GC (P.J. Marriott); Coupled-Column Liquid Chromatography (C. Corradini); Supercritical Fluid Techniques Coupled with Chromatographic Techniques (F.M. Lancas); Unified Chromatography: Concepts and Considerations for Multidimensional Chromatography (T.L. Chester); Multidimensional Planar Chromatography (Sz. Nyiredy); Multidimensional Electrodriven Separations (M.M. Degen and V.T. Remcho) APPLICATIONS; Foods, Flavours and Fragrances Applications (G. Dugo et al); Biomedical and Pharmaceutical Applications (G.W. Somsen and G.J. de Jong); Industrial and Polymer Applications (Y.V. Kazakevich and R. LoBrutto); Multidimensional Chromatography in Environmental Analysis (R.M. Marce ); Multidimensional Chromatography in the Oil Industry (J. Beens); Forensic and Toxicological Applications.
Category: Science

Materials Analysis In Forensic Science

Author : Max M. Houck
ISBN : 9780128006733
Genre : Law
File Size : 88.5 MB
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The Advanced Forensic Science Series grew out of the recommendations from the 2009 NAS Report: Strengthening Forensic Science: A Path Forward. This volume, Materials Analysis in Forensic Science will serve as a graduate level text for those studying and teaching materials analysis in forensic science. It will also prove an excellent reference for forensic practitioner’s libraries or use in their casework. Coverage includes methods, textiles, explosives, glass, coatings, geo-and bio-materials, marks and impressions, as well as various other materials and professional issues the reader may encounter. Edited by a world-renowned leading forensic expert, the Advanced Forensic Science Series is a long overdue solution for the forensic science community. Provides basic principles of forensic science and an overview of materials analysis Contains information on a wide variety of trace evidence Covers methods, textiles, explosives, glass, coatings, geo-and bio-materials, marks and impressions, as well as various other materials Includes a section on professional issues, such as: from crime scene to court, lab reports, health and safety, and field deployable devices Incorporates effective pedagogy, key terms, review questions, discussion question and additional reading suggestions
Category: Law

Neuropathology Of Drug Addictions And Substance Misuse Volume 2

Author : Victor R. Preedy
ISBN : 9780128003756
Genre : Psychology
File Size : 76.28 MB
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Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader’s knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 2 addresses stimulants, club and dissociative drugs, hallucinogens, and inhalants and solvents. Each section provides data on the general, molecular and cellular, and structural and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention, and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad material and substances. Offers a modern approach to understanding the pathology of substances of abuse, offering an evidence-based ethos for understanding the neurology of addictions Fills an existing gap in the literature by serving as a “one-stop-shopping synopsis of everything to do with the neuropathology of drugs of addiction and substance misuse Includes in each chapter: list of abbreviations, abstract, introduction, applications to other addictions and substance misuse, mini-dictionary of terms, summary points, 6+ figures and tables, and full references Offers coverage of preclinical, clinical, and population studies, from the cell to whole organs, and from the genome to whole body
Category: Psychology

Retention And Selectivity In Liquid Chromatography

Author : R.M. Smith
ISBN : 0080858651
Genre : Science
File Size : 52.95 MB
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This book brings together a number of studies which examine the ways in which the retention and selectivity of separations in high-performance liquid chromatography are dependent on the chemical structure of the analytes and the properties of the stationary and mobile phases. Although previous authors have described the optimisation of separations by alteration of the mobile phase, little emphasis has previously been reported of the influence of the structure and properties of the analyte. The initial chapters describe methods based on retention index group increments and log P increments for the prediction of the retention of analytes and the ways in which these factors are influenced by mobile phases and intramolecular interactions. The values of a wide range of group increments in different eluents are tabulated. Different scales of retention indices in liquid chromatography are described for the comparison of separations, the identification of analytes and the comparison of stationary phases. Applications of these methods in the pharmaceutical, toxicology, forensic, metabolism, environmental, food and other fields are reviewed. The effects of different mobile phases on the selectivity of the retention indices are reported. A compilation of sources of reported retention index values are given. Methods for the comparison of stationary phases based on the interactions of different analytes are covered, including lipophilic and polar indices, shape selectivity comparisons, their application to novel stationary phases, and chemometric methods for column comparisons.
Category: Science

Handbook Of Hplc Second Edition

Author : Danilo Corradini
ISBN : 1420016946
Genre : Science
File Size : 58.9 MB
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High performance liquid chromatography (HPLC) is one of the most widespread analytical and preparative scale separation techniques used for both scientific investigations and industrial and biomedical analysis. Now in its second edition, this revised and updated version of the Handbook of HPLC examines the new advances made in this field since the publication of the benchmark first edition twelve years ago. It reports detailed information on fundamental and practical aspects of HPLC related to conventional format and sophisticated novel approaches which have been developed to address a variety of separation problems in different fields. The latest concepts New concepts presented in this edition include monolithic columns, bonded stationary phases, micro-HPLC, two-dimensional comprehensive liquid chromatography, gradient elution mode, and capillary electromigration techniques. The book also discusses LC-MS interfaces, nonlinear chromatography, displacement chromatography of peptides and proteins, field-flow fractionation, retention models for ions, and polymer HPLC. Fundamentals and applications The first section of the book explores emerging novel aspects of HPLC and related separation methods based on the differential velocity of analytes in a liquid medium under the action of either an electric field (capillary electromigration techniques) or a gravitational field (field-flow fractionation). The section focusing on applications highlights four significant areas in which HPLC is successfully employed: chiral pharmaceutical, environmental analysis, food analysis, and forensic science. Ideal for a widespread audience Explanatory figures and tables supplement the text and clarify difficult concepts. Extensive references provide gateways to more focused study. Suitable for undergraduates or new practitioners interested in improving their knowledge on the current status and future trends of HPLC, the book is also a critical resource for researchers looking for solutions to complex separation problems or those who currently use HPLC either as an analytical or a preparative scale tool.
Category: Science